Phenylarsine oxide (PAO) more intensely induces apoptosis in acute promyelocytic leukemia and As2O3-resistant APL cell lines than As2O3 by activating the mitochondrial pathway

Leukemia and Lymphoma

Volumn 45, Issue 5, 2004, Pages 987-995

  Sahara, Naohi ^a   Takeshita, Akihiro ^a   Kobayashi, Miki ^a   Shigeno, Kazuyuki ^a   Nakamura, Satoki ^a   Shinjo, Kaori ^a   Naito, Kensuke ^a   Maekawa, Masato ^a   Horii, Toshinobu ^a   Ohnishi, Kazunori ^a   Kitamura, Kunio ^b   Naoe, Tomoki ^b   Hayashi, Hideharu ^a   Ohno, Ryuzo ^c  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Acute promyelocytic leukemia; Apoptosis; Arsenic trioxide; Mitochondrial pathway; Phenylarsine oxide

Indexed keywords

ARSENIC TRIOXIDE; ARSENOSOBENZENE; PROTEIN BCL 2; PROTEIN BCL XL; RHODAMINE 123;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CANCER REGRESSION; CANCER RESISTANCE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DIPLOIDY; DOWN REGULATION; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; ARSENICALS; BCL-X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 11144354005     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190310001617222     Document Type: Article

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