The peroxisome proliterator-activated receptor α activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation

Journal of Cardiovascular Pharmacology

Volumn 44, Issue SUPPL. 1, 2004, Pages

  Ogata, Takehiro ^a   Miyauchi, Takashi ^a   Irukayama Tomobe, Yoko ^a   Takanashi, Masakatsu ^a   Goto, Katsutoshi ^a   Yamaguchi, Iwao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

c jun; Cardiac fibroblasts; Endothelin 1; Peroxisome proliferator activated receptor ; Proliferation

Indexed keywords

ENDOTHELIN 1; FENOFIBRATE; MESSENGER RNA; PROTEIN C FOS; PROTEIN C JUN; ANTILIPEMIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL CELL; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; FIBROBLAST; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; ARTICLE; CELL CULTURE; DNA REPLICATION; DOWN REGULATION; DRUG POTENTIATION; GENETICS; HEART VENTRICLE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ANTILIPEMIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; DNA REPLICATION; DOWN-REGULATION; ENDOTHELIN-1; FIBROBLASTS; HEART VENTRICLES; PPAR ALPHA; PROCETOFEN; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 11144333682     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000166274.24797.0e     Document Type: Conference Paper

References (18)

1. Vasan RS, Larson MG, Benjamin EJ, et al. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction. J Am Coll Cardiol. 1999;33:1948-1955.
2. Staels B, Koenig W, Habib A, et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature. 1998;393:790-793.
3. Delerive P, De Bosscher K, Besnard S, et al. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J Biol Chem. 1999;274:32048-32054.
4. Zhan Y, Kim S, Yasumoto H, et al. Effects of dominant-negative c-Jun on platelet-derived growth factor-induced vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol. 2002;22:82-88.
5. 1-to-S phase transition. Mol Cell Biol. 1995;15:2612-2624.
6. Kakinuma Y Miyauchi T, Yuki K, et al. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor HIF-1α induced for impaired myocardial energy metabolism. Circulation. 2001;103:2387-2394.
7. Sakai S, Miyauchi T, Yamaguchi I, et al. Long-term endothelin receptor antagonist administration improves alterations in expression of various cardiac genes in failing myocardium rats with heart failure. Circulation. 2000;101:2849-2853.
8. Yamauchi-Kohno R, Miyauchi T, Hoshino T, et al. Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin A antagonist on survival and cardiac function. Circulation. 1999;99:2171-2176.
9. Takuwa N, Takuwa Y, Yanagisawa M, et al. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. J Biol Chem. 1989;264:7856-7861.
10. Ogata T, Miyauchi T, Sakai S, et al. Stimulation of peroxisome- proliferator-activated receptor α (PPARα) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts. Clin Sci. 2002;103:284S-288S.
11. Delerive P, Martin-Nizard F, Chinetti G, et al. Peroxisome proliferator-activated receptors inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res. 1999;85:394-402.
12. 1 transition in mouse fibroblasts. Nature. 1988;334:535-537.
13. Quantin B, Breathnach R. Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature. 1988;334:538-539.
14. Kovary K, Bravo R. The jun and fos protein families are both required for cell progression in fibroblasts. Mol Cell Biol. 1991;11:4466-4472.
15. 1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994;78:67-74.
16. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78:59-66.
17. Kip1 for restriction point control of the fibroblast cell cycle. Science. 1996;272:877-880.
18. 0 state) in fibroblasts. J Biol Chem. 1996;271:18337-18341.