Comparison of rapid liquid chromatography-electrospray ionization-tandem mass spectrometry methods for determination of glycoalkaloids in transgenic field-grown potatoes

Analytical Biochemistry

Volumn 336, Issue 2, 2005, Pages 178-186

  Zywicki, Britta ^a   Catchpole, Gareth ^a   Draper, John ^b   Fiehn, Oliver ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Fructans; High throughput screening; Hydrophilic interaction; Liquid chromatography; Mass spectrometry; Metabolite profiling; Method validation; Reversed phase; Substantial equivalence

Indexed keywords

DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; PLANTS (BOTANY); POSITIVE IONS;

FRUCTANS; HIGH THROUGHPUT SCREENING; HYDROPHILIC INTERACTION; METABOLITE PROFILING; METHOD VALIDATIONS; REVERSED PHASE; SUBSTANTIAL EQUIVALENCES;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ALKALOID DERIVATIVE; ALPHA CHACONINE; ALPHA SOLANINE; INULIN; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CULTIVAR; ELECTROSPRAY MASS SPECTROMETRY; GENETIC ENGINEERING; GENETICALLY MODIFIED FOOD; HIGH THROUGHPUT SCREENING; HYDROPHILICITY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; METABOLITE; MOLECULAR INTERACTION; MONITORING; NONHUMAN; PLANT BREEDING; PLANT TUBER; POTATO; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; TRANSGENIC PLANT; VALIDATION PROCESS;

SOLANUM TUBEROSUM;

EID: 11144326227     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2004.10.013     Document Type: Article

References (27)

1. OECD: Guidance document for the risk assessment of genetically modified plants and derived food and feed. Paris: Organisation for Economic Co-operation and Development, 2003
2. A. Zitnak, and G.R. Johnston Glycoalkaloids and bitterness in potatoes Am. Pot. J. 47 1970 256 260
3. K.E. Hellenäs, C. Branzell, H. Johnsson, and P. Slanina High levels of glycoalkaloids in the established swedish potato variety Magnum bonum J. Sci. Food Agric. 68 1995 249 255
4. OECD: Food safety evaluation. Paris: Organisation for Economic Co-operation and Development, 1996
5. W.M.J. van Gelder Determination of the total C-27-steroidal alkaloid composition of solanum species by high resolution gas chromatography J. Chromatogr. 331 1985 285 293
6. J.A. Maga Glycoalkaloids in solanaceae Food Rev. Int. 10 1994 385 418
7. S.C. Morris, and T.H. Lee The toxicity and teratogenicity of solanaceae glycoalkaloids, particularly those of the potato (Solanum tuberosum)-a review Food Technol. Aust. 36 1984 118 124
8. S.J. Jadhav, R.P. Sharma, and D.K. Salunkhe Naturally occurring toxic alkaloids in foods CRC Crit. Rev. Toxicol. 9 1981 21 104
9. W.M.J. van Gelder A.F.M. Rizk Poisonous Plant Contamination of Edible Plants 1991 CRC Press Boston 118 156
10. G.R. Gibson, E.R. Beatty, X. Wang, and J.H. Cummings Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin Gastroenterology 108 1995 108 975
11. I.R. Rowland, C.J. Rumney, J.T. Coutts, and L.C. Lievense Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats Carcinogenesis 19 1998 281 285
12. A.G. Heyer, J.R. Lloyd, and J. Kossmann Production of modified polymeric carbohydrates Curr. Opin. Plant Biotech. 10 1999 169 174
13. J. Edelman, and T.G. Jefford Mechanism of fructosan metabolism in higher plants as exemplified in Helianthus tuberosus New Phytol. 67 1968 517 531
14. W. van den Ende, and A. van Laere Fructan synthesizing and degrading activities in chicory roots (Cichorium intybus L.) during field-growth, storage and forcing J. Plant Physiol. 149 1996 43 50
15. W. Weckwerth, M.E. Loureiro, K. Wenzel, and O. Fiehn Metabolic networks unravel the effects of silent plant phenotypes Proc. Natl. Acad. Sci. USA 101 2004 7809 7814
16. F. Kvasnicka, K.R. Price, K. Ng, and G.R. Fenwick Determination of potato glycoalkaloids using isotachophoresis and comparison with a HPLC method J. Liq. Chromatogr. 17 1994 1941 1951
17. P. Cavlovic, M. Mankotia, and P. Pantozopoulos Liquid chromatographic determination of alpha-solasonine in frozen green peas as an indicator of the presence of nightshade berries J. Assoc. Off. Anal. Chem. Int. 86 2003
18. M. Friedman, J.N. Roitman, and N. Kozukue Glycoalkaloid and calystegine contents of eight potato cultivars J. Agric. Food Chem. 51 2003 2964 2973
19. N. Kozukue, J. Han, K. Lee, and M. Friedman Dehydrotomatine and alpha-tomatine content in tomato fruits and vegetative plant tissues J. Agric. Food Chem. 52 2004 2079 2083
20. E.M. Hellwege, D. Gritscher, L. Willmitzer, and A.G. Heyer Transgenic potato tubers accumulate high levels of 1-kestose and nystose: functional identification of a sucrose sucrose 1-fructosyltransferase of artichoke (Cynara scolymus) blossom discs Plant J. 12 1997 1057 1065
21. E.M. Hellwege, S. Czapla, A. Jahnke, L. Willmitzer, and A.G. Heyer Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots Proc. Natl. Acad. Sci. USA 97 2000 8699 8704
22. W. Weckwerth, K. Wenzel, and O. Fiehn Process for the integrated extraction identification, and quantification of metabolites, proteins and RNA to reveal their co-regulation in biochemical networks Proteomics 4 2004 78 83
23. M. Friedman, J.R. Rayburn, and J.A. Bantle Structural relationships and developmental toxicity of Solanum alkaloids in the frog embryo teratogenesis assay-xenopus J. Agric. Food Chem. 40 1992 1617 1624
24. M. Friedman, and G.M. McDonald Potato glycoalkaloids: chemistry, analysis, safety, and plant physiology Crit. Rev. Plant Sci. 16 1997 55 132
25. G. Bianco, P. Schmitt-Kopplin, A. Crescenzi, S. Comes, A. Kettrup, and T.R.I. Cataldi Evaluation of glycoalkaloids in tubers of genetically modified virus Y-resistant potato plants (var. Desiree) by non-aqueous capillary electrophoresis coupled with electrospray ionization mass spectrometry (NACE-ESI-MS) Anal. Bioanal. Chem. 375 2003 799 804
26. H.A. Kuiper, and G.A. Kleter The scientific basis for risk assessment and regulation of genetically modified foods Trends Food Sci. Tech. 14 2003 277 293
27. I.S. Krull, and M. Swartz Analytical method development and validation for the academic researcher Anal. Lett. 32 1999 1067 1080