Physiological roles of angiotensin-converting enzyme 2

Cellular and Molecular Life Sciences

Volumn 61, Issue 21, 2004, Pages 2714-2719

  Danilczyk, U ^a,b   Eriksson, U ^c   Oudit, G Y ^d   Penninger, J M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiotensin converting enzyme 2; Knockout mice; Renin angiotensin system

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

BLOOD PRESSURE MONITORING; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HEART FUNCTION; HUMAN; KIDNEY FUNCTION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; REVIEW; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CARBOXYPEPTIDASES; HUMANS; KIDNEY; MYOCARDIUM; PEPTIDYL-DIPEPTIDASE A; SUBSTRATE SPECIFICITY;

EID: 11144314776     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-004-4241-6     Document Type: Review

References (40)

1. Skeggs L. T. (1956) The preparation and function of the hypertensin converting enzyme. J. Exp. Med. 103: 295-299
2. Cushman D. W. and Ondetto M. A. (1980) Inhibitors of angiotensin- converting enzyme for treatment of hypertension. Biochem. Pharmacol. 29: 1871-1877
3. Turner A. J. and Hooper N. M. (2002) The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol. Sci. 23: 177-183
4. Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N. et al. (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 87: E1-E9
5. Tipnis S. R., Hooper N. M., Hyde R., Karran E., Christie G. and Turner A. J. (2000) A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275: 33238-33243
6. Crackower M. A., Sarao R., Oudit G. Y., Yagil C., Kozieradzki I., Scanga S. E. et al. (2002) Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822-828
7. Yagil C., Katni G., Rubattu S., Stolpe C., Kreutz R., Lindpaintner K. et al. (1996) Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of salt sensitivity and resistance. J. Hypertens. 14: 1175-1182
8. Yagil C., Sapojnikov M., Kreutz R., Zurcher H., Ganten D. and Yagil Y. (1999) Role of chromosome X in the Sabra rat model of salt-sensitive hypertension. Hypertension 33: 261-265
9. Harmer D., Gilbert M., Borman R. and Clark K.L. (2002) Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett. 532: 107-110
10. Komatsu T., Suzuki Y., Imai J., Sugano S., Hida M., Tanigami A. et al. (2002) Molecular cloning, mRNA expression and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2). DNA Seq. 13: 217-220
11. Eriksson U., Danilczyk U. and Penninger J. M. (2002) Just the beginning: novel functions for angiotensin-converting enzymes. Curr. Biol. 12: R745-R752
12. Danilczyk U., Eriksson U., Crackower M. A. and Penninger J. M. (2003) A story of two ACEs. J. Mol. Med. 81: 227-234
13. Inagami T. (1994) The renin angiotensin system. Essays Biochem. 28: 147-164
14. Johnson H., Kourtis S., Waters J. and Drummer O. H. (1989) Radioimmunoassay for immunoreactive [des-Leu10]-angiotensin I Peptides (Elmsford) 10: 489-492
15. Oparil S., Tregear G. W., Koerner T., Barnes B. A. and Haber E. (1971) Mechanism of pulmonary conversion of angiotensin I to angiotensin II in the dog. Circ. Res. 29: 682-690
16. Drummer O. H., Kourtis S. and Johnson H. (1990) Effect of chronic enalapril treatment on enzymes responsible for the catabolism of angiotensin I and formation of angiotensin II. Biochem. Pharmacol. 39: 513-518
17. Huang L., Sexton D. L., Skogerson K., Devlin M., Smith R., Sanyal I. et al. (2003) Novel peptide inhibitors of angiotensin-converting enzyme 2. J. Biol. Chem. 278: 15532-15540
18. Vickers C., Hales P., Kaushik V., Dick L., Gavin J., Tang J. et al. (2002) Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J. Biol. Chem. 277: 14838-14843
19. Iyer S. N., Averill D. B., Chappell M. C., Yamada K., Allred A. J. and Ferrario C. M. (2000) Contribution of angiotensin-(1-7) to blood pressure regulation in salt-depleted hypertensive rats. Hypertension 36: 417-422
20. Ren Y., Garvin J. L. and Carretero O. A. (2002) Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension 39: 799-802
21. Duka I., Kintsurashvili E., Gavras I., Johns C., Bresnahan M. and Gavras H. (2001) Vasoactive potential of the B(1) bradykinin receptor in normotension and hypertension. Circ. Res. 88: 275-281
22. Hosoya M., Kawamata Y., Fukusumi S., Fujii R., Habata Y., Hinuma S. et al. (2000) Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J. Biol. Chem. 275: 21061-21067
23. Tatemoto K., Takayama K., Zou, M. X., Kumaki I., Zhang W., Kumano K. et al. (2001) The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul. Pept. 99: 87-92
24. Ventura C., Spurgeon H., Lakatta E. G., Guarnieri C. and Capogrossi M. C. (1992) Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons. Circ. Res. 70: 66-81
25. Hilbert P., Lindpaintner K., Beckmann J. S., Serikawa T., Soubrier F., Dubay C. et al. (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353: 521-529
26. Yagil Y. and Yagil C. (2003) Hypothesis: ACE2 modulates blood pressure in the mammalian organism. Hypertension 41: 871-873
27. Oudit G. Y., Crackower M. A., Backx P. H. and Penninger J. M. (2003) The role of ACE2 in cardiovascular physiology. Trends Cardiovasc. Med. 13: 93-101
28. Allred A. J., Donoghue M., Acton S. and Coffman T. M. (2002) Regulation of blood pressure by the angiotensin converting enzyme homologue ACE2. Paper presented at 35th Annual Meeting of the American Society of Nephrology, 1-4 November 2002, Philadelphia, PA. Abstract available at http://www. abstracts-on-line.com/abstracts/asn/aol.asp
29. Krege J. H., John S. W., Langenbach L. L., Hodgin J. B., Hagaman J. R., Bachman E. S. et al. (1995) Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375: 146-148
30. Esther C. R. Jr, Howard T. E., Marino E. M., Goddard J. M., Capecchi M. R. and Bernstein K. E. (1996) Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology and reduced male fertility. Lab. Invest. 74: 953-965
31. Tanimoto K., Sugiyama F., Goto Y., Ishida J., Takimoto E., Yagami K. et al. (1994) Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269: 31334-31337
32. Murphy A. M., Kogler H., Georgakopoulos D., McDonough J. E., Kass D. A., Van Eyk J. E. et al. (2000) Transgenic mouse model of stunned myocardium. Science 287: 488-491
33. Heusch G. (1998) Hibernating myocardium. Physiol. Rev. 78: 1055-1085
34. Sowter H. M., Ratcliffe P. J., Watson P., Greenberg A. H. and Harris A. E. (2001) HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer. Res. 61: 6669-6673
35. Kietzmann T., Roth U. and Jungermann K. (1999) Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185
36. Giordano F. J., Gerber H. P., Williams S. P., VanBruggen N., Bunting S., Ruiz-Lozano P. et al. (2001) A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc. Natl. Acad. Sci. USA 98: 5780-5785
37. Kurokawa K. (1998). Tubuloglomerular feedback: its physiological and pathophysiological significance. Kidney Int. Suppl. 67: S71-S74
38. Tikellis C., Johnston C. I., Forbes J. M., Burns W. C., Burrell L. M., Risvanis J. et al. (2003) Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension 41: 392-397
39. Ferrario C. M., Martell N., Yunis C., Flack J. M., Chappell M. C., Brosnihan K. B. et al. (1998) Characterization of angiotensin-(1-7) in the urine of normal and essential hypertensive subjects. Am. J. Hypertens. 11: 137-146
40. Brosnihan K. B., Neves L. A., Joyner J., Averill D. B., Chappell M. C., Sarao R. et al. (2003) Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension [Epub ahead of print)