Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of salt sensitivity and resistance

Journal of Hypertension

Volumn 14, Issue 10, 1996, Pages 1175-1182

  Yagil, Ghana ^a   Katni, Gurion ^a   Rubattu, Speranza ^b,c,d   Stolpe, Christoph ^e   Kreutz, Reinhold ^b,c,d   Lindpaintner, Klaus ^b,c,d   Ganten, Detlev ^e   Ben Ishay, Drori ^f   Yagil, Yoram ^a,g  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^g BARZILAI MEDICAL CENTER   (Israel)

Author keywords

Genotype; Inbreeding; Microsatellites; Phenotype; Sabra rats; Salt resistance; Salt sensitivity

Indexed keywords

DEOXYCORTICOSTERONE ACETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENETIC MARKER; GENETIC POLYMORPHISM; GENOTYPE; HYPERTENSION; INBREEDING; LOADING TEST; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUALITY CONTROL; RAT; SALT INTAKE; SYSTOLIC BLOOD PRESSURE; TAIL; TELEMETRY;

EID: 10244246589     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199610000-00004     Document Type: Article

References (18)

1. Simpson FO: Blood pressure and sodium intake. In: Hypertension: Patho-physiology, Diagnosis, and Management. Edited by Laragh JH, Brenner BM. New York: Raven Press; 1990, 15:205-215.
2. Lindpaintner K: What can the molecular genetics of hypertensive rats teach us about the genetics of hypertension in humans? Curr Sci 1994, 3:30-38.
3. Ganten D: Role of animal models in hypertension research. Hypertension 1987, 9 (suppl I):I-2-I-4.
4. Dahl LK, Heine M, Tassinari L: Effects of chronic salt ingestion: evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exp Med 1962, 115:1173-1190.
5. Rapp JP: Dahl salt-susceptible and salt-resistant rats. Hypertension 1982, 4:753-763.
6. Rapp JP, Dene H: Development and characteristics of inbred strains of Dahl salt sensitive and salt resistant rats. Hypertension 1985, 7: 340-349.
7. Iwai J: Dahl salt sensitive and salt resistant rats. Hypertension 1987, 9 (suppl I):18-20.
8. Ben-Ishay D, Saliternik R, Welner A: Separation of two strains of rats with inbred dissimilar sensitivity to doca-salt hypertension. Experientia 1972, 28:1321-1322.
9. Ben-Ishay D, Mekler J, Saliternick-Vardi R: Sabra hypertension-prone and hypertension-resistant rats. Hypertension 1987, 9 (suppl I):I-24-I-26.
10. Ben-Ishay D, Yagil Y: The Sabra hypertension-prone and -resistant strains. In Experimental and Genetic Models of Hypertension. Edited by Ganten D, de Jong W. Amsterdam: Elsevier Science BV; 1994:272-299.
11. Lezin EM, Pravenec M, Wong A, Wang J, Merriouns T, Newton S, et al.: Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt sensitive hypertension. Hypertension 1994, 23:786-790.
12. Kurtz TW, Montana M, Chan L, Kabra PM: Molecular evidence of genetic heterogeneity in Wistar-Kyoto rats: implications for research with the spontaneously hypertensive rat. Hypertension 1989, 13:188-192.
13. Lewis JL, Russel RJ, Warnock DG: Analysis of the genetic contamination of salt-sensitive Dahl/Rapp rats. Hypertension 1994, 24:255-259.
14. Calhoun DA, Zhu S, Wyss M, Oparil S: Diurnal blood pressure variation and dietary salt in spontaneously hypertensive rats. Hypertension 1994, 24:1-7.
15. Lemmer B, Mattes A, Bohm M, Ganten D: Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993, 22: 97-101.
16. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, et al.: A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genetics 1995, 9:63-69.
17. Gu I, Dene H, Deng AY, Hoebee B, Bihoreau M-T, James M, et al.: Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest 1996, 97:777-788.
18. Schorer-Apelbaum D, Weinstock M, Ben-Ishay D: Sympathetic component of baroreflex control of heart rate is impaired in hypertension-prone (SBH) Sabra rats. J Hypertens 1984, 2:257-260.