Robust multipoint identical-by-descent mapping for affected relative pairs

American Journal of Human Genetics

Volumn 76, Issue 1, 2005, Pages 128-138

  Schaid, Daniel J ^a   Sinnwell, Jason P ^a   Thibodeau, Stephen N ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; EPISTASIS; GENE MAPPING; GENETIC MODEL; GENETIC TRAIT; HEREDITY; HUMAN; LINKAGE ANALYSIS; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROSTATE CANCER; RELATIVE; SIBLING;

EID: 11144308846     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/427343     Document Type: Article

References (18)

1. Abecasis G, Cherny S, Cookson W, Cardon L (2002) Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101
2. Biernacka JM, Sun L, Bull SB (2004) Simultaneous localization of two linked disease susceptibility genes. Genet Epidemiol (electronically published October 12, 2004; accessed November 15, 2004)
3. Boos DD (1992) On generalized score tests. Am Stat 46:327-333
4. Easton DF, Schaid DJ, Whittemore AS, Isaacs WJ (2003) Where are the prostate cancer genes? A summary of eight genome wide searches. Prostate 57:261-269
5. Glidden DV, Liang KY, Chiu YF, Pulver AE (2003) Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases. Genet Epidemiol 24:107-117
6. Göring HHH, Terwilliger JD, Blangero J (2001) Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 69:1357-1369
7. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A (2000) Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13
8. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
9. Liang K-Y, Chiu Y-F, Beaty TH (2001a). A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases. Hum Hered 51:64-78
10. - (2001b). Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions. Genet Epidemiol 21:105-122
11. Liang K-Y, Huang C-Y, Beaty TH (2000) A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sib pairs. Am J Hum Genet 66:1631-1641
12. McCarthy MI, Kruglyak L, Lander ES (1998) Sib-pair collection strategies for complex diseases. Genet Epidemiol 15:317-340
13. Risch N (1990a) Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46:222-228
14. - (1990b) Linkage strategies for genetically complex traits. II. The power of affected relative pairs, a quantitative trait and a marker locus. Am J Hum Genet 46:229-241
15. Schaid DJ, Buetow K, Weeks DE, Wijsman E, Guo SW, Ott J, Dahl C (1999) Discovery of cancer susceptibility genes: study designs, analytic approaches, and trends in technology. J Natl Cancer Inst Monogr 26:1-16
16. Schaid DJ, Guenther JC, Christensen GB, Hebbring S, Rosenow C, Hilker CA, McDonnell SK, Cunningham JM, Slager SL, Blute ML, Thibodeau SN (2004) Comparison of microsatellites versus single nucleotide polymorphisms by a genome linkage screen for prostate cancer susceptibility loci. Am J Hum Genet 75:948-965
17. White H (1982) Maximum likelihood estimation of misspecified models. Econometrika 50:1-25
18. Zeger SL, Liang K-Y (1986) Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:121-130