Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

Prostate

Volumn 57, Issue 4, 2003, Pages 261-269

  Easton, Douglas F ^a   Schaid, Daniel J ^b   Whittemore, Alice S ^c   Isaacs, William J ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MAYO CLINIC   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Genetic linkage analysis; ICPCG; Non parametric linkage; Parametric linkage; Prostate cancer susceptibility

Indexed keywords

CANCER FAMILY; CANCER GENETICS; CANCER RISK; CANCER SUSCEPTIBILITY; FAMILY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; LINKAGE ANALYSIS; MALE; PARAMETRIC TEST; PRIORITY JOURNAL; PROSTATE CANCER; RELIABILITY; REVIEW; RISK FACTOR;

GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; PROSTATIC NEOPLASMS;

EID: 0345688716     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.10300     Document Type: Review

References (53)

1. Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. A systematic population based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 1994;86:1600-1608.
2. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
3. Carter BS, Beaty TH, Steinberg GD, Childs B, Walsh PC. Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci USA 1992;89:3367-3371.
4. Schaid DJ, McDonnell SK, Blute ML, Thibodeau SN. Evidence for autosomal dominant inheritance of prostate cancer. Am J Hum Genet 1998;62:1425-1438.
5. Gronberg H, Damber L, Damber JE, Iselius L. Segregation analysis of prostate cancer in Sweden: Support for dominant inheritance. Am J Epidemiol 1997;146:552-557.
6. Verhage BA, Baffoe-Bonnie AB, Baglietto L, Smith DS, Bailey-Wilson JE, Beaty TH, Catalona WJ, Kiemeney LA. Autosomal dominant inheritance of prostate cancer: A confirmatory study. Urology 2001;57:97-101.
7. Valeri A, Briollais L, Azzouzi R, Fournier G, Mangin P, Berthon P, Cussenot O, Demenais F. Segregation analysis of prostate cancer in France: Evidence for autosomal dominant inheritance and residual brother-brother dependence. Ann Hum Genet 2003;67:125-137.
8. Monroe KR, Yu MC, Kolonel LN, Coetzee GA, Wilkens LR, Ross RK, Henderson BE. Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nat Med 1995;1:827-829.
9. Cui J, Staples MP, Hopper JL, English DR, McCredie MR, Giles GG. Segregation analyses of 1,476 population-based Australian families affected by prostate cancer. Am J Hum Genet 2001;68:1207-1218.
10. Gong G, Oakley-Girvan I, Wu AH, Kolonel LN, John EM, West DW, Felberg A, Gallagher RP, Whittemore AS. Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and Canada. Cancer Causes Control 2002;13:471-482.
11. Risch N. The genetic epidemiology of cancer: Interpreting familial and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev 2001;10:733-741.
12. Smith JR, Freije D, Carpten JD, Gronberg H, Xu J, Isaacs SD, Brownstein MJ, Bova GS, Guo H, Bujnovszky P, Nusskern DR, Damber JE, Bergh A, Emanuelsson M, Kallioniemi OP, Walker-Daniels J, Bailey-Wilson JE, Beaty TH, Meyers DA, Walsh PC, Collins FS, Trent JM, Isaacs WB. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 1996;274:1371-1374.
13. Cooney KA, McCarthy JD, Lange E, Huang L, Miesfeldt S, Monite JE, Oesterling JE, Sandler JM, Lange K. Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study. J Natl Cancer Inst 1997;89:955-959.
14. Hsieh CL, Oakley-Girvan I, Gallagher RP, Wu AH, Kolonel LN, Teh CZ, Halpern J, West DW, Paffenbarger RS Jr, Whittemore AS. Re: Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study. J Natl Cancer Inst 1997;89:1893-1894.
15. McIndoe RA, Stanford JL, Gibbs M, Jarvik GP, Brandzel S, Neal CL, Li S, Gammack JT, Gay AA, Goode EL, Hood L, Ostrander EA. Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet 1997;61:347-353.
16. Berthon P, Valeri A, Cohen-Akenine A, Drelon E, Paiss T, Wohr G, Latil A, Millasseau P, Mellah I, Cohen N, Blanche H, Bellane-Chantelot C, Demenais F, Teillac P, Le Duc A, de Petriconi R, Hautmann R, Chumakov I, Bachner L, Maitland NJ, Lidereau R, Vogel W, Fournier G, Mangin P, Cohen D, Cussenot O. Predisposing gene for early-onset prostate cancer, localised on chromosome 1q42.2-43. Am J Hum Genet 1998;62:1416-1424.
17. Eeles RA, Simard J, Teare D, Edwards S, Durocher F, Badzioch M, Hamoudi R, Gill S, Biggs P, Dearnaley D, Ardern-Jones A, Dowe A, Shearer R, Ford D, Amos C, The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Linkage analysis of chromosome 1q markers in 136 prostate cancer families. Am J Hum Genet 1998;62:653-658.
18. Xu J. Combined analysis of hereditary prostate cancer linkage 1q24-25: Results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. Am J Hum Genet 2000;66:945-957.
19. Xu J, Meyers DA, Freije D, Isaacs S, Wiley K, Nusskern D, Ewing C, Wilkens E, Bujnovszky P, Bova GS, Walsh P, Isaacs W, Schleutker J, Matikainen M, Tammela T, Visakorpi T, Kallioniemi OP, Berry R, Schaid D, French A, McDonnell S, Schroeder J, Blute M, Thibodeau S, Grönberg H, Emanuelsson M, Damber JE, Bergh A, Jonsson BA, Smith J, Bailey-Wilson J, Carpten J, Stephan D, Gillanders E, Amundson I, Kainu T, Freas-Lutz D, Baffoe-Bonnie A, Van Auken A, Sood R, Collins F, Brownstein M, Trent J. Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat Genet 1998;20:175-179.
20. Schleutker J, Matikainen M, Smith J, Koivisto P, Baffoe-Bonnie A, Kainu T, Gillanders E, Sankila R, Pukkala E, Carpten J, Stephan D, Tammela T, Brownstein M, Bailey-Wilson J, Trent J, Kallioniemi OP. A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: Frequent HPCX linkage in families with late-onset disease. Clin Cancer Res 2000;6:4810-4815.
21. Bochum S, Paiss T, Vogel W, Herkommer K, Hautmann R, Haeussler J. Confirmation of the prostate cancer susceptibility locus HPCX in a set of 104 German prostate cancer families. Prostate 2002;52:12-19.
22. Cancel-Tassin G, Latil A, Valeri A, Mangin P, Fournier G, Berthon P, Cussenot O. PCAP is the major known prostate cancer predisposing locus in families from south and west Europe. Eur J Hum Genet 2001;9:135-142.
23. Peters MA, Jarvik GP, Janer M, Chakrabarti L, Kolb S, Goode EL, Gibbs M, DuBois CC, Schuster EF, Hood L, Ostrander EA, Stanford JL. Genetic linkage analysis of prostate cancer families to Xq27-28. Hum Hered 2001;51:107-113.
24. Lange EM, Chen H, Brierley K, Perrone EE, Bock CH, Gillanders E, Ray ME, Cooney KA. Linkage analysis of 153 prostate cancer families over a 30-cM region containing the putative susceptibility locus HPCX. Clin Cancer Res 1999;5:4013-4020.
25. Xu J, Zheng SL, Hawkins GA, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang B, Ewing CM, Bujnovszky P, Carpten JD, Bleecker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB. Linkage and association studies of prostate cancer susceptibility: Evidence for linkage at 8p22-23. Am J Hum Genet 2001;69:341-350.
26. Suarez BK, Lin J, Burmester JK, Broman K, Weber JL, Banerjee TK, Goddard KA, Witte JS, Elston RC, Catalona WJ. A genome screen of multiplex sibships with prostate cancer. Am J Hum Genet 2000;66:933-944.
27. Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA. A candidate prostate cancer susceptibility gene at chromosome 17p. Nature Genet 2001;27:172-180.
28. Berry R, Schroeder JJ, French AJ, McDonnell SK, Peterson BJ, Cunningham JM, Thibodeau SN, Schaid DJ. Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am J Hum Genet 2000;67:82-91.
29. Gibbs M, Stanford JL, McIndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley VA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet 1999;64:776-787.
30. Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nature Genet 2002;30:181-184.
31. Xu J, Zheng SL, Komiya A, Mychaleckyj JC, Isaacs SD, Hu JJ, Sterling D, Lange EM, Hawkins GA, Turner A, Ewing CM, Faith DA, Johnson JR, Suzuki H, Bujnovszky, P, Wiley KE, DeMarzo AM, Bova GS, Chang B, Hall MC, McCullough DL, Partin AW, Kassabian VS, Carpten JD, Bailey-Wilson JE, Trent JM, Ohar J, Bleecker ER, Walsh PC, Isaacs WB, Meyers DA. Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nature Genet 2002;32:321-325.
32. Severi G, Giles GG, Southey MC, Tesoriero A, Tilley W, Neufing P, Morris H, English DR, McCredie MR, Boyle P, Hopper JL. ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer. J Natl Cancer Inst 2003;95:818-824.
33. Cunningham JM, McDonnell SK, Marks A, Hebbring S, Anderson SA, Peterson BJ, Slager S, French A, Blute ML, Schaid DJ, Thibodeau SN. Genome linkage screen for prostate cancer susceptibility loci: Results from the Mayo Clinic Familial Prostate Cancer Study. Prostate 2003;57:335-346.
34. The International ACTANE Consortium. Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE Consortium. Prostate 2003;57:270-279.
35. Janer M, Fredrichsen D, Stanford JL, Badzioch MD, Kolb S, Deutsch K, Peters MA, Goode EL, Welti R, DeFrance HB, Iwasaki L, Li S, Hood L, Ostrander EA, Jarvik GP. A genomic scan of 254 hereditary prostate cancer families. Prostate 2003;57:309-319.
36. Lange EM, Gillanders EM, Davis CC, Brown WM, Campbell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Giri V, Dimmer JB, Montie J, Trent J, Cooney KA. Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan Prostate Cancer Genetics Projects finds evidence for linkage on chromosome 17 near BRCA1. Prostate 2003;57:326-334.
37. Schleutker J, Baffoe-Bonnie AB, Gillanders E, Kainu T, Jones M-P, Freas-Lutz D, Markey C, Gibbs KD Jr, Matikainen M, Koivisto PA, Tammela T, Bailey-Wilson JE, Trent J, Kallioniemi O-P. A genome-wide scan for linkage in Finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-p26. Prostate 2003;57:280-289.
38. Wiklund F, Gillanders EM, Albertus JA, Bergh A, Damber J-E, Emanuelsson M, Freas-Lutz DL, Gildea DE, Göransson I, Jones MS, Jonsson B-A, Lindmark F, Markey CJ, Riedesel EL, Stenman E, Trent JM, Grönberg H. A genome-wide scan of Swedish families with hereditary prostate cancer: Suggestive evidence of linkage at 5q11.2 and 19p13.3. Prostate 2003;57:290-297.
39. Witte JS, Suarez BK, Thiel B, Lin J, Yu A, Banerjee TK, Burmester JK, Casey G, Catalona WJ. Genome-wide scan of brothers: Replication and fine mapping of prostate cancer susceptibility and aggressiveness loci. Prostate 2003;57:298-308.
40. Xu J, Gillanders EM, Wiley KE, Chang B-I, Isaacs SD, Zheng SL, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Meyers DA, Walsh PC, Trent JM, Isaacs WB. Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families. Prostate 2003;57:320-325.
41. Hsieh CL, Oakley-Girvan I, Balise RR, Halpern J, Gallagher RP, Wu AH, Kolonel LN, O'Brien LE, Lin IG, Van Den Berg DJ, Teh CZ, West DW, Whittemore AS. A genome screen of families with multiple cases of prostate cancer: Evidence of genetic heterogeneity. Am J Hum Genet 2001;69:148-158.
42. Risch N, Giuffra L. Model misspecification and multipoint linkage analysis. Hum Hered 1992;42:77-92.
43. Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 1999;91:1310-1316.
44. Thompson D, Easton DF. Cancer incidence in BRCA1 mutation carriers. J Natl Cancer Inst 2002;94:1358-1365.
45. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994;265:2037-2048.
46. Sawcer S, Jones HB, Judge D, Visser F, Compston A, Goodfellow PN, Clayton D. Empirical genomewide significance levels established by whole genome simulations. Genet Epidemiol 1997;14:223-229.
47. Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990;250(4988):1684-1689.
48. Narod SA, Feunteun J, Lynch HT, Watson P, Conway T, Lynch J, Lenoir GM. Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet 1991;338(8759):82-83.
49. Witte JS, Goddard KA, Conti DV, Elston RC, Lin J, Suarez BK, Broman KW, Burmester JK, Weber JL, Catalona WJ. Genome-wide scan for prostate cancer-aggressiveness loci. Am J Hum Genet 2000;67:92-99.
50. Slager S, Schaid D, Cunningham J, McDonnell S, Marks A, Peterson B, Hebbring S, Anderson S, French A, Thibodeau S. Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. Am J Hum Genet 2003;72:759-762.
51. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997;61:1179-1188.
52. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: A unified approach. Am J Hum Genet 1996;58:1347-1363.
53. Whittemore AS, Halpern J. A class of tests for linkage using affected pedigree members. Biometrics 1994;50:118-127.