The immune-enhancing enteral agents arginine and glutamine differentially modulate gut barrier function following mesenteric ischemia/reperfusion

Journal of Trauma - Injury, Infection and Critical Care

Volumn 57, Issue 6, 2004, Pages 1150-1156

  Kozar, Rosemary A ^a,b   Verner Cole, Elizabeth ^a   Schultz, Stanley G ^a   Sato, Nario ^a   Bick, Roger J ^b   DeSoignie, Roland ^a   Poindexter, Brian J ^b   Moore, Frederick A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Immune enhancing agents Arginine Glutamine Ischemia; Reperfusion Intestinal permeability Gut barrier function Cytoskeleton F:G actin ratio

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININE; F ACTIN; FRUCTOSE; G ACTIN; GLUTAMINE; MAGNESIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENTERIC FEEDING; HISTOLOGY; IMMUNITY; INTENSIVE CARE; INTESTINE FUNCTION; INTESTINE INJURY; INTESTINE ISCHEMIA; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; LAPAROTOMY; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION;

ACTINS; ADJUVANTS, IMMUNOLOGIC; ANALYSIS OF VARIANCE; ANIMALS; ARGININE; CELL MEMBRANE PERMEABILITY; CYTOSKELETON; ENTERAL NUTRITION; GLUTAMINE; INTESTINAL MUCOSA; MALE; MESENTERIC VASCULAR OCCLUSION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 11144229403     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TA.0000151273.01810.E9     Document Type: Article

References (40)

1. Moore FA, Feliciano DV, Andrassy RJ, et al. Early enteral feeding, compared with patenteral, reduces postoperative septic complications-the results of a meta-analysis. Ann Surg. 1992;216:172-183.
2. Moore FA, Moore EE, Kudsk KA, et al. Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. J Trauma. 1994;37:607-615.
3. Kudsk KA, Minard G, Croce MA, et al. A randomized trial of isonitrogenous enteral diets following severe trauma: an immune-enhancing diet reduces complications. Ann Surg. 1996;224:531-543.
4. Weidman A, Bastian L, Bischoff WE, et al. Influence of arginine, omega-3-fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma. Nutrition. 1998;14:165-172.
5. Heyland DK, Novak F, Drover JW, Jain M, Su X, Suchner U. Should immunonutrition become routine in the critically ill patient? JAMA. 2001;286:944-953.
6. Suchner U, Heyland DK, Peter K. Immune-modulatory actions of arginine in the critically ill. Br J Nutrition. 2002;87:S121-S132.
7. Kompan L, Kompan D. Importance of increased intestinal permeability after multiple injuries. Eur J Surg. 2001;167:570-574.
8. Faries PF, Simon RJ, Martella AT, Lee MJ, Machiedo GW. Intestinal permeability correlates with severity of injury in trauma patients. J Trauma. 1998;44:1037-1036.
9. Doig CJ, Sutherland LR, Sandham JD, Pick GH, Verhoef M, Meddings JB. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med. 1998;158:444-451.
10. Han X, Fink MP, Yang R, Delude RL. Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock. 2004;21:261-270.
11. Deitch EA, Shi HP, Lu Q, Feketeova E, Xu DZ. Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury. Shock. 2003;19:452-456.
12. Deitch EA, Xy DZ, Franko L, Ayala A, Chaudry IH. Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock. 1995;1:141-146.
13. Aranow JS, Fink MP. Determinants of intestinal barrier failure in critical illness. Br J Anaesth. 1996;77:71-81.
14. Luyer MD, Buurman WA, Hadfoune M, et al. Pretreatment with high-fat enteral nutrition reduces endotoxin and tumor necrosis factor-alpha and preserves gut barrier function early after hemorrhagic shock. Shock. 2004;21:65-71.
15. Kompan L, Kremzar B, Gadzijev E, Prosek M. Effects of early enteral nutrition on intestinal permeability and the development of multiple organ failure after multiple injury. Intensive Care Med. 1999;25:157-161.
16. Houdijk APJ, Rijnsburger ER, Jansen J, et al. Randomized trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998;352:772-776.
17. Garrel D, Patenaude J, Nedelec B, et al. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial. Crit Care Med. 2003;31:2444-2449.
18. Wischmeyer PE, Lynch J, Liedel J, et al. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med. 2001;29:2075-2080.
19. Kozar RA, Schultz SG, Bick RJ, Poindexter BJ, DeSoignie R, Moore FA. Enteral glutamine but not alanine maintains small bowel barrier function after ischemia/reperfusion injury in rats. Shock. 2004;21:433-437.
20. Kozar RA, Schultz SG, Hassoun HT, et al. The type of sodium-coupled solute modulates small bowel mucosal injury, transport function, and ATP after ischemia/reperfusion injury in rats. Gastroenterology. 2002;123:810-816.
21. Chiu C, McArdle AH, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low flow states: A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101:478-483.
22. Poindexter BJ, Pereia-Smith O, Wadhwa R, Buja LM, Bick RJ. 3D reconstruction and localization of mortalin by deconvolution microscopy. Microscopy and Analysis. 2002;89:21-23.
23. Unno N, Menconi MJ, Salzman AL, et al. Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2Bbe monolayers. Am J Physiol 1996;270:G1010-G1021.
24. Salzman AL, Menconi MJ, Unno N, et al. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2Bbe intestinal epithelial monolayers. Am J Physiol 1995 268(2 Pt 1):G261-G373.
25. Field M, Fromm D, McColl I. Ion transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit current. Am J Physiology. 1971;220:1388-1396.
26. Heys SD, Walker LG, Smith I, Eremin O. Enteral nutrition supplementation with key nutrients in patients with critical illness and cancer. Ann Surg. 1999;229:467-477.
27. Beale RJ, Bryg DJ, Bihari DJ. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med. 1999;27:2799-2805.
28. Dent DL, Heyland DK, Levy H, et al. Immunonutrition may increase mortality in critically ill patients with pneumonia: results of a randomized trial. Crit Care Med. 2003;30:A17.
29. Heyland DK, Samis A. Does immunonutriton in patients with sepsis do more harm than good? Intensive Care Med. 2003;29:669-671.
30. Mendez C, Jurkovich GJ, Garcia, et al. Effects of an immune-enhancing diet in critically injured patients. J Trauma. 1997;42:933.
31. Moore FA, Moore EE, Kudsk KA, et al. Clinical benefits of an immune-enhancing diet for early post injury enteral feeding. J Trauma 1994;37:607-615.
32. Ochoa JB, Bernard AC, O'Brien WE, et al. Arginase expression and activity in human mononuclear cells after injury. Ann Surg 2001;223:393-399.
33. Bernard AC, Mistry SK, Morris SM et al. Alterations in arginine metabolic enzymes in trauma. Shock. 2001;15:215-219.
34. Fukatusu MD, Ueno C, Nagayoshi H, Hara E, Mochizaki K, Hiraide H. Effects of L-arginine infusion during ischemia on gut perfusion, oxygen tension, and circulating myeloid cell activation in murine gut ischemia/reperfusion model. Presented at Nutrition Week (ASPEN) January 2004.
35. Kozar RA, Holcomb JB, Hassoun HT, Macaitis J, DeSoignie R, Moore FA. Superior mesenteric artery occlusion models shock-induced gut ischemia-reperfusion. J Surg Res. 2004;116:145-150.
36. Wattanasirichaigoon S, Menconi MJ, Delude RL, Fink MP. Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats. Shock. 1999;12:127-133.
37. Schleiffer R, Raul F. Prophylactic administration of L-arginine improves the intestinal barrier function after mesenteric ischemia. Gut 1996;39:194-198.
38. Luo CC, Chen HM, Chiu CH, Lin JN, Chen JC. Effect of N (G)-nitro-L-arginine methyl ester on intestinal ischemia-reperfusion injury in a rat model. Biol Neonate. 2001;80:60-63.
39. Ohtake K, Maeno T, Ueda H, Ogihara M, Natsume H, Morimoto Y. Poly- L- Arginine enhances paracellular permeability via serine/rhreonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium. Pharm Res. 2003;20:1838-1845.
40. Han X, Fink MP, Delude RL. Proinflammatory cytokines cause NO-dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock. 2003;19:229-237.