Position paper: Systemic antibiotics in periodontics

Journal of Periodontology

Volumn 75, Issue 11, 2004, Pages 1553-1565

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALUMINUM; AMOXICILLIN; ANTACID AGENT; ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; ASTEMIZOLE; AZITHROMYCIN; BARBITURIC ACID DERIVATIVE; BISMUTH; CAFFEINE; CARBAMAZEPINE; CIPROFLOXACIN; CISAPRIDE; CLARITHROMYCIN; CLINDAMYCIN; CYCLOSPORIN; DIAZEPAM; DIGOXIN; DOXYCYCLINE; ERYTHROMYCIN; HYDANTOIN; IRON; MAGNESIUM; METHYLPREDNISOLONE; METRONIDAZOLE; TERFENADINE; THEOPHYLLINE; UNINDEXED DRUG; WARFARIN; ANTIINFECTIVE AGENT;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANTIBIOTIC SENSITIVITY; APNEA; ARTHROPATHY; BETA HEMOLYTIC STREPTOCOCCUS; CAMPYLOBACTER; CANDIDA ALBICANS; DISEASE ASSOCIATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENTIATION; EIKENELLA CORRODENS; ENTEROCOCCUS FAECALIS; EUBACTERIUM; FUSOBACTERIUM NUCLEATUM; GRAM NEGATIVE BACTERIUM; GROWTH DISORDER; HEART ARRHYTHMIA; HUMAN; MEDICAL DECISION MAKING; NAUSEA AND VOMITING; PATIENT SELECTION; PEPTOSTREPTOCOCCUS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; PREVOTELLA INTERMEDIA; PSEUDOMONAS; REVIEW; SEIZURE; SELENOMONAS; SPIROCHETE; STAPHYLOCOCCUS; TERATOGENICITY; TOOTH COLOR; TOOTH DISEASE; TREATMENT OUTCOME; TREPONEMA DENTICOLA; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG COMBINATION; ORAL DRUG ADMINISTRATION; PERIODONTAL DISEASE; PERIODONTICS; PRACTICE GUIDELINE; STANDARD;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY, COMBINATION; HUMANS; PATIENT SELECTION; PERIODONTAL DISEASES; PERIODONTICS;

EID: 10944252426     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.11.1553     Document Type: Review

References (84)

1. Pallasch TJ, Slots J. Antibiotic prophylaxis and the medically-compromised patient. Periodontol 2000 1996;10:107-138.
2. Dajani AS, Taubert KA, Wilson W, et al. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. JAMA 1997;277:794-801.
3. Paster BJ, Boches SK, Galvin JL, et al. Bacterial diversity in human subgingival plaque. J Bacteriol 2001; 183:3770-3783.
4. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111.
5. Slots J, Chen C. The oral microflora and human periodontal disease. In: G.W. Tannock, ed. Medical Importance of the Normal Microflora. London: Kluwer Academic Publishers; 1999:101-127.
6. Walker CB. The acquisition of antibiotic resistance in the periodontal flora. Periodontol 2000 1996; 10:78-88.
7. Slots J, Rams TE. New views on periodontal microbiota in special patient categories. J Clin Periodontol 1991; 18:411-420.
8. Schenkein HA, Van Dyke TE. Early-onset periodontitis: Systemic aspects of etiology and pathogenesis. Periodontol 2000 1994;6:7-25.
9. Van Dyke TE. Special patient categories. Periodontol 2000 1994;6:7-124.
10. Johnson BD, Engel D. Acute necrotizing ulcerative gingivitis: A review of diagnosis, etiology and treatment. J Periodontol 1986;57:141-150.
11. Slots J, Rams TE. Antibiotics in periodontal therapy: Advantages and disadvantages. J Clin Periodontol 1990;17:479-493.
12. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003;8:115-181.
13. Pallasch TJ. Pharmacokinetic principles of antimicrobial therapy. Periodontol 2000 1996;10:5-11.
14. van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996; 10: 45-78.
15. Socransky SS, Haffajee AD. Dental biofilms: Difficult therapeutic targets. Periodontol 2000 2002;28:12-55.
16. van Winkelhoff AJ, van der Velden U, Clement M, de Graaff J. Intra-oral distribution of black-pigmented Bacteroides species in periodontitis patients. Oral Microbiol Immunol 1988;3:83-85.
17. Müller HP, Eickholz P, Heinecke A, Pohl S, Milller RF, Lange DE. Simultaneous isolation of Actinobacillus actinomycetemcomitans from subgingival and extra-crevicular locations of the mouth. J Clin Periodontol 1995;22:413-419.
18. Asikainen S, Chen C. Oral ecology and person-to-person transmission of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999;20:65-81.
19. Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994;5:142-168.
20. Walker CB. Selected antimicrobial agents: Mechanism of action, side effects and drug interactions. Periodontol 2000 1996;10:12-28.
21. Loesche WJ, Grossman N, Giordano J. Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. J Clin Periodontol 1993; 20:96-104.
22. van Winkelhoff AJ, Herrera Gonzales D, Winkel EG, Dellemijn-Kippuw N, Vandenbroucke-Grauls CM, Sanz M. Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis. A comparison between The Netherlands and Spain. J Clin Periodontol 2000; 27:79-86.
23. Pavicic MJAMP, van Winkelhoff AJ, de Graaff J. In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations. Antimicrob Agents Chemother 1992;36:2634-2638.
24. Eliopoulos GM. Synergism and antagonism. Infect Dis Clin North Am 1989;3:399-406.
25. Root RK. Clinical Infectious Diseases: A Practical Approach. New York: Oxford University Press; 1999.
26. Ellen RP, McCulloch CAG. Evidence versus empiricism: Rational use of systemic antimicrobials for treatment of periodontitis. Periodontol 2000 1996;10:29-44.
27. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis: Reduced need for surgery. J Clin Periodontol 1992;19:103-112.
28. Saxén L, Asikainen S. Metronidazole in the treatment of localized juvenile periodontitis. J Clin Periodontol 1993;20:166-171.
29. Nieminen A, Asikainen S, Torkko H, Kari K, Uitto VJ, Saxén L. Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis. J Clin Periodontol 1996;23:572-581.
30. Palmer RM, Matthews JP, Wilson RF. Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: A controlled clinical study. Br Dent J 1998;184:548-552.
31. Söder B, Nedlich U, Jin LJ. Longitudinal effect of nonsurgical treatment and systemic metronidazole for 1 week in smokers and non-smokers with refractory periodontitis: A 5-year study. J Periodontol 1999;70:761-771.
32. Gordon J, Walker C, Lamster I, West T, Socransky SS, Seiger M, Fasciano R. Efficacy of clindamycin hydrochloride in refractory periodontitis-12 months results. J Periodontol 1985;56:(Suppl. 11)75-80.
33. Gordon J, Walker C, Hovliaris C, Socransky SS. Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. J Periodontol 1990;61:686-691.
34. Walker C, Gordon J. The effect of clindamycin on the microbiota associated with refractory periodontitis. J Periodontol 1990;61:692-698.
35. Kunihira DM, Caine FA, Palcanis KG, Best AM, Ranney RR. A clinical trial of phenoxymethyl penicillin for adjunctive treatment of juvenile periodontitis. J Periodontol 1985;56:352-358.
36. Haffajee AD, Dibart S, Kent RL Jr, Socransky SS. Clinical and microbiological changes associated with the use of 4 adjunctively administered agents in the treatment of periodontal infections. J Clin Periodontol 1995;2-2:618-627.
37. Winkel EG, van Winkelhoff AJ, Barendregt DS, van der Weijden GA, Timmerman MF, van der Velden U. Clinical and microbiological effects of initial periodontal therapy in conjunction with amoxicillin and clavulanic acid in patients with adult periodontitis. A randomised double-blind, placebo-controlled study. J Clin Periodontol 1999;26:461-468.
38. Rams TE, Keyes PH. A rationale for the management of periodontal diseases: Effects of tetracycline on subgingival bacteria. J Am Dent Assoc 1983;107:37-41.
39. Novak MJ, Polson AM, Adair SM. Tetracycline therapy in patients with early juvenile periodontitis. J Periodontol 1988:59:366-372.
40. Saxén L, Asikainen S, Kanervo A, Kari K, Jousimies-Somer H. The long-term efficacy of systemic doxycycline medication in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. Arch Oral Biol 1990;35:227S-229S.
41. Haffajee AD, Dibart S, Kent RL Jr, Socransky SS. Clinical and microbiological changes associated with the use of 4 adjunctively administered agents in the treatment of periodontal infections. J Clin Periodontol 1995;22.618-627.
42. Ramberg P, Rosling B, Serino G, Hellstrom MK, Socransky SS, Undhe J. The long-term effect of systemic tetracycline used as an adjunct to non-surgical treatment of advanced periodontitis. J Clin Periodontol 2001;28:446-452.
43. Smith SR, Foyle DM, Daniels J, et al. A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: Clinical results. J Clin Periodontol 2002;29:54-61.
44. van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1992;63:52-57.
45. Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol 1998;25: 354-362.
46. Flemmig TF, Milian E, Karch H, Klaiber B. Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. J Clin Periodontol 1998;25:380-387.
47. Winkel EG, van Winkelhoff AJ, Timmerman MF, Van der Velden U, van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 2001;28:296-305.
48. Slots J, Schonfeld SE. Actinobacillus actinomycetemcomitants in localized juvenile periodontitis. In: Hamada S, Holt SC, McGhee, JR, eds. Periodontal Disease. Pathogens & Host Immune Responses. Tokyo: Quintessence Publishing Co., Ltd.; 1991.53-64.
49. Rams TE, Babalola OO, Slots J. Subgingival occurrence of enteric rods, yeasts and staphylococci after systemic doxycycline therapy. Oral Microbiol Immunol 1990;5: 166-168.
50. Olsvik B, Hansen BF, Tenover FC, Olsen I. Tetracycline-resistant micro-organisms recovered from patients with refractory periodontal disease. J Clin Periodontol 1995; 22:391-396.
51. Slots J, Pallasch TJ. Dentists' role in halting antimicrobial resistance. J Dent Res 1996;75:1338-1341.
52. Roberts MC. Antibiotic toxicity, interactions and resistance development. Periodontol 2000 2002;28:280-297.
53. Duckworth R, Waterhouse JP, Britton DE, et al. Acute ulcerative gingivitis. A double-blind controlled clinical trial of metronidazole. Br Dent J 1966 21;120:599-602.
54. van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989;16:128-131.
55. Tinoco EM, Beldi MI, Campedelli F, et al. Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial. J Periodontol 1998;69:1355-1363.
56. Listgarten MA, Loomer PM. Microbial identification in the management of periodontal diseases: A systematic review. Ann Periodontol 2003;8:182-192.
57. Helovuo H, Hakkarainen K, Paunio K. Changes in the prevalence of subgingival enteric rods, staphylococci and yeasts after treatment with penicillin and erythromycin. Oral Microbiol Immunol 1993;8:75-79.
58. Gunsolley JC, Chinchilli VN, Savid ED, et al. Analysis of site specific periodontal bacteria sampling schemes. J Periodontol 1992;63:507-514.
59. Walker C, Karpinia K. Rationale for use of antibiotics in periodontics. J Periodontol 2002;73:1188-1196.
60. Mellado JR, Freedman AL, Salkin LM, Stein MD, Schneider DB, Cutler RH. The clinical relevance of microbiologic testing: A comparative analysis of microbiologic samples secured from the same sites and cultured in two independent laboratories. Int J Periodontics Restorative Dent 2001;21:232-239.
61. Zambon JJ, Haraszthy A. The laboratory diagnosis of periodontal infections. Periodontol 2000 1995;7:69-82.
62. Chen C, Slots J. Microbiological tests for Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999;20:53-64.
63. American Academy of Periodontology. Parameter on "refractory" periodontitis. J Periodontol 2000; 71:859-860.
64. Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontol 2000 2002;28:106-176.
65. Slots J, van Winkelhoff AJ. Antimicrobial therapy in periodontics. J Calif Dent Assoc 1993;21 (Nov.):51-56.
66. Britt MR, Pohlod DJ. Serum and crevicular fluid concentrations after a single oral dose of metronidazole. J Periodontol 1986;57:104-107.
67. Van Oosten MA, Notten FJ, Mikx FH. Metronidazole concentrations in human plasma, saliva, and gingival crevice fluid after a single dose. J Dent Res 1986;65:1420-1423.
68. Sakellari D, Goodson JM, Kolokotronis A, Konstantinidis A. Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol 2000;27: 53-60.
69. Ryan ME, Golub LM. Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy. Periodontol 2000 2000;24:226-238.
70. Slots J, Feik D, Rams TE. In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis. Oral Microbiol Immunol 1990;5: 298-301.
71. Conway TB, Beck FM, Walters JD. Gingival fluid ciprofloxacin levels at healthy and inflamed human periodontal sites. J Periodontol 2000;71:1448-1452.
72. Blandizzi C, Malizia T, Lupetti A, et al. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol 1999;70:960-966.
73. Sefton AM, Maskell JP, Beighton D, et al. Azithromycin in the treatment of periodontal disease. Effect on microbial flora. J Clin Periodontol 1996;23:998-1003.
74. Goldstein EJ, Citron DM, Merriam CV, Warren Y, Tyrrell K. Comparative in vitro activities of ABT-773 against aerobic and anaerobic pathogens isolated from skin and soft-tissue animal and human bite wound infections. Antimicrob Agents Chemother 2000;44:2525-2529.
75. Williams JD, Maskell JP, Shain H, et al. Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J Antimicrob Chemother 1992;30:27-37.
76. Kornman KS, Newman MG, Moore DJ, Singer RE. The influence of supragingival plaque control on clinical and microbial outcomes following the use of antibiotics for the treatment of periodontitis. J Periodontol 1994; 65:848-854.
77. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979;50:495-509.
78. Sefton AM. Macrolides and changes in the oral flora. Int J Antimicrob Agents 1999; 11 (Suppl. 1):S23-S29; discussion S31-S32.
79. Feres M, Haffajee AD, Goncalves C, et al. Systemic doxycycline administration in the treatment of periodontal infections (II). Effect on antibiotic resistance of subgingival species. J Clin Periodontol 1999;26:784-792.
80. Chen C, Slots J. The current status and future prospects of altering the pathogenic microflora of periodontal disease. Curr Opin Periodontol 1993;71-77.
81. van der Reijden WA, Dellemijn-Kippuw N, Stijne-van Nes AM, de Soet JJ, van Winkelhoff AJ. Mutans streptococci in subgingival plaque of treated and untreated patients with periodontitis. J Clin Periodontol 2001; 28:686-691.
82. Dahlén G. Microbiology and treatment of dental abscesses and periodontal-endodontic lesions. Periodontol 2000 2002;28:206-239.
83. Slots J. Subgingival microflora and periodontal disease. J Clin Periodontol 1979;6:351-382.
84. Jenkins WM, MacFarlane IV, Gilmour WH, Ramsey I, MacKenzie D. Systemic metronidazole in the treatment of periodontitis. J Clin Periodontol 1989;16:443-450.