Evidence for expression in human liver of halothane‐induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis

Hepatology

Volumn 8, Issue 6, 1988, Pages 1635-1641

  Kenna, J Gerald ^a   Neuberger, James ^a   Williams, Roger ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE;

CLINICAL ARTICLE; DRUG HYPERSENSITIVITY; HEPATITIS; HUMAN; LIVER TOXICITY; NEOANTIGEN; PRIORITY JOURNAL;

ADULT; AGED; ANTIBODIES; ANTIGENS; FEMALE; HALOTHANE; HEPATITIS; HEPATITIS, TOXIC; HUMAN; MALE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0024267822     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.1840080627     Document Type: Article

References (19)

1. Unexplained hepatitis following halothane
2. Halothane hepatitis: a model of immune mediated drug hepatotoxicity
3. A perspective on halothane‐induced hepatotoxicity
4. Adverse effects of volatile anesthetics
5. Unexplained hepatitis following halothane
6. Drug‐induced hepatitis associated with anticytoplasmic organelle autoantibodies
7. Antibodies to the surface of halothane‐altered rabbit hepatocytes in patients with severe halothane‐associated hepatitis
8. An enzyme‐linked immunosorbent assay for detection of antibodies to halothane‐altered hepatocyte antigens
9. Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia
10. Identification by immunoblotting of three halothane‐induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane hepatitis
11. Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. The in vitro metabolism of halothane (2‐bromo‐2‐chloro‐1,1,1‐trifluoroethane) by hepatic microsomal cytochrome P‐450
14. 14C]halothane
15. Induction by drugs of hepatitis and autoantibodies to cell organelles: significance and interpretation
16. Urinary metabolites of halothane in man
17. Investigation of the immunological basis of halothane‐induced hepatotoxicity
18. Differences in the biotrans‐formation of halothane in man