Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae

Genetics

Volumn 168, Issue 3, 2004, Pages 1159-1176

  Aye, Michael ^a   Irwin, Becky ^a   Beliakova Bethell, Nadejda ^a   Chen, Eric ^a   Garrus, Jennifer ^b   Sandmeyer, Suzanne ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GALACTOSE; HOST FACTOR 1; INTEGRASE; TRANSFER RNA;

ARTICLE; BACTERIUM MUTANT; CELL CYCLE; CHROMATIN STRUCTURE; GENE EXPRESSION; GENE INSERTION; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC SCREENING; GENETIC TRANSCRIPTION; KNOCKOUT GENE; NONHUMAN; NUCLEAR IMPORT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION; RETROPOSON; RETROVIRUS; RNA PROCESSING; SACCHAROMYCES CEREVISIAE; WILD TYPE;

CARRIER PROTEINS; DNA, COMPLEMENTARY; MUTATION; RECOMBINATION, GENETIC; RETROELEMENTS; RNA, TRANSFER, VAL; RNA-DIRECTED DNA POLYMERASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

BACTERIA (MICROORGANISMS); INSERTION SEQUENCES; MAMMALIA; RNA VIRUSES; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; UNIDENTIFIED RETROVIRUS;

EID: 10844293486     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.028126     Document Type: Article

References (105)

1. ALLEN, N. P., L. HUANG, A. BURLINGAME and M. REXACH, 2001 Proteomic analysis of nucleoporin interacting proteins. J. Biol. Chem. 276: 29268-29274.
2. AYE, M., and S. B. SANDMEYER, 2003 Ty3 requires yeast La homologous protein for wild-type frequencies of transposition. Mol. Microbiol. 49: 501-515.
3. AYE, M., S. L. DILDINE, J. A. CLAYPOOL, S. JOURDAIN and S. B. SANDMEYER, 2001 A truncation mutant of the 95-kilodalton subunit of transcription factor IIIC reveals asymmetry in Ty3 integration. Mol. Cell. Biol. 21: 7839-7851.
4. BALASUNDARAM, D., M. J. BENEDIK, M. MORPHEW, V. D. DANG and H. L. LEVIN, 1999 Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tfl. Mol. Cell. Biol. 19: 5768-5784.
5. BEHRENS, R., J. HAYLES and P. NURSE, 2000 Fission yeast retrotransposon Tfl integration is targeted to 5′ ends of open reading frames. Nucleic Acids Res. 28: 4709-4716.
6. BEST, S., P. R. LETISSIER and J. P. STOYE, 1997 Endogenous retroviruses and the evolution of resistance to retroviral infection. Trends Microbiol. 5: 313-318.
7. BIENIASZ, P. D., 2003 Restriction factors: a defense against retroviral infection. Trends Microbiol. 11: 286-291.
8. BILANCHONE, V. W., J. A. CLAYPOOL, P. T. KINSEY and S. B. SANDMEYER, 1993 Positive and negative regulatory elements control expression of the yeast retrotransposon Ty3. Genetics 134: 685-700.
9. BOEKE, J. D., and S. B. SANDMEYER, 1991 Yeast transposable elements, pp. 193-261 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics, edited by J. PRINGLE, E. JONES and J. HABER. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
10. BOEKE, J. D., and J. P. STOYE, 1997 Retrotransposons, endogenous retroviruses, and the evolution of retroelements, pp. 343-436 in Retroviruses, edited by J. M. COFFIN, S. H. HUGHES and H. E. VARMUS. Cold Spring Harbor Laboratory Press, Plainview, NY.
11. BOLTON, E. C., A. S. MILDVAN and J. D. BOEKE, 2002 Inhibition of reverse transcription in vivo by elevated manganese ion concentration. Mol. Cell 9: 879-889.
12. BOUBE, M., L. JOULIA, D. L. CRIBBS and H. M. BOURBON, 2002 Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110: 143-151.
13. BRAATEN, D., E. K. FRANKE and J. LUBAN, 1996 Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J. Virol. 70: 3551-3560.
14. BURNS, N., B. GRIMWADE, P. B. ROSS-MACDONALD, E.-Y. CHOI, K. FINBERG et al., 1994 Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev. 8: 1087-1105.
15. BURTON, J. L., and M. J. SOLOMON, 2001 D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev. 15: 2381-2395.
16. CHALKER, D. L., and S. B. SANDMEYER, 1992 Ty3 integrates within the region of RNA polymerase III transcription initiation. Genes Dev. 6: 117-128.
17. CHAPMAN, K. B., and J. D. BOEKE, 1991 Isolation and characterization of the gene encoding yeast debranching enzyme. Cell 65: 483-492.
18. CLARK, D. J., V. W. BILANCHONE, L. J. HAYWOOD, S. L. DILDINE and S. B. SANDMEYER, 1988 A yeast sigma composite element, Ty3, has properties of a retrotransposon. J. Biol. Chem. 263: 1413-1423.
19. CLARK, M. W., W. W. ZHONG, T. KENG, R. K. STORMS, A. BARTON et al., 1992 Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8: 133-145.
20. COCKELL, M., H. RENAULD, P. WATT and S. M. GASSER, 1998 Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast. Curr. Biol. 8: 787-790.
21. COFFIN, J., 1996 Retroviridiae, pp. 763-843 in Fields Virology, edited by B. N. FIELDS, D. M. KNIPE, P. M. HOWLEY, R. M. CHANOCK, J. L. MELNICK et al. Lippincott-Raven Press, Philadelphia.
22. COLLART, M. A., and K. STRUHL, 1993 CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO J. 12: 177-186.
23. CONTE, D., JR., and M. J. CURCIO, 2000 Fus3 controls Ty1 transpositional dormancy through the invasive growth MAPK pathway. Mol. Microbiol. 35: 415-427.
24. DANG, V. D., and H. L. LEVIN, 2000 Nuclear import of the retrotransposon Tfl is governed by a nuclear localization signal that possesses a unique requirement for the FXFG nuclear pore factor nup124p. Mol. Cell. Biol. 20: 7798-7812.
25. DANIEL, R., R. A. KATZ and A. M. SKALKA, 1999 A role for DNA-PK in retroviral DNA integration. Science 284: 644-647.
26. DEVINE, S. E., and J. D. BOEKE, 1996 Integration of the yeast retrotransposon Ty1 is targeted to regions upstream of genes transcribed by RNA polymerase III. Genes Dev. 10: 620-633.
27. DOWNS, J. A., and S. P. JACKSON, 1999 Involvement of DNA end-binding protein Ku in Ty element retrotransposition. Mol. Cell. Biol. 19: 6260-6268.
28. DVORIN, J. D., and M. H. MALIM, 2003 Intracellular trafficking of HIV-1 cores: journey to the center of the cell. Curr. Top. Microbiol. Immunol. 281: 179-208.
29. ERREDE, B., R. M. CADE, B. M. YASHAR, Y. KAMADA, D. E. LEVIN et al., 1995 Dynamics and organization of map kinase signal pathways. Mol. Reprod. Dev. 42: 477-485.
30. FARABAUGH, P. J., 1995 Post-transcriptional regulation of transposition by Ty retrotransposons of Saccharomyces cerevisiae. J. Biol. Chem. 270: 10361-10364.
31. FARNET, C. M., and F. D. BUSHMAN, 1997 HIV-1 cDNA integration: requirement of HMG 1(Y) protein for function of preintegration complexes in vitro. Cell 88: 483-492.
32. FLEISCHMANN, M., I. STAGLJAR and M. AEBI, 1996 Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol. Gen. Genet. 250: 614-625.
33. FRITSCH, E., and H. M. TEMIN, 1977a Formation and structure of infectious DNA of spleen necrosis virus. J. Virol. 21: 119-130.
34. FRITSCH, E. F., and H. M. TEMIN, 1977b Inhibition of viral DNA synthesis in stationary chicken embryo fibroblasts infected with avian retroviruses. J. Virol. 24: 461-469.
35. GARFINKEL, D. J., and A. BAILIS, 2002 Nucleotide excision repair, genome stability and human disease: new insight from model systems. J. Biomed. Biotechnol. 2: 55-60.
36. GHAVIDEL, A., and M. C. SCHULTZ, 1997 Casein kinase II regulation of yeast TFIIIB is mediated by the TATA-binding protein. Genes Dev. 11: 2780-2789.
37. GOFF, S. P., 2001 Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways. J. Gene Med. 3: 517-528.
38. 0-arrested Balb c/3T3 fibroblasts. Virology 200: 87-97.
39. GRAHAM, L. A., B. POWELL and T. H. STEVENS, 2000 Composition and assembly of the yeast vacuolar H+-ATPase complex. J. Exp. Biol. 203: 61-70.
40. GREENE, W. C., and B. M. PETERLIN, 2002 Charting HIV's remarkable voyage through the cell: basic science as a passport to future therapy. Nat. Med. 8: 673-680.
41. GRIFFITH, J. L., L. E. COLEMAN, A. S. RAYMOND, S. G. GOODSON, W. S. PITTARD et al., 2003 Functional genomics reveals relationships between the retrovirus-like TyI element and its host Saccharomyces cerevisiae. Genetics 164: 867-879.
42. HANSEN, L. J., D. L. CHALKER, K. J. ORLINSKY and S. B. SANDMEYER, 1992 Ty3 GAG3 and POL3 genes encode the components of intracellular particles. J. Virol. 66: 1414-1424.
43. HAREL, J., E. RASSART and P. JOLICOEUR, 1981 Cell cycle dependence of synthesis of unintegrated viral DNA in mouse cells newly infected with murine leukemia virus. Virology 110: 202-207.
44. HARRIS, R. S., K. N. BISHOP, A. M. SHEEHY, H. M. CRAIG, S. K. PETERSEN-MAHRT et al., 2003 DNA determination mediates innate immunity to retroviral infection. Cell 113: 803-809.
45. HINDMARSH, P., T. RIDKY, R. REEVES, M. ANDRAKE, A. M. SKALKA et al., 1999 HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J. Virol. 73: 2994-3003.
46. HOFFMAN, C. S., and F. WINSTON, 1987 A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57: 267-272.
47. HULL, M. W., J. ERICKSON, M. JOHNSTON and D. R. ENGELKE, 1994 tRNA genes as transcriptional repressor elements. Mol. Cell. Biol. 14: 1266-1277.
48. IRNIGER, S., 2002 Cyclin destruction in mitosis: a crucial task of Cdc20. FEBS Lett. 532: 7-11.
49. ITO, H., Y. FUKUDA, K. MURATA and A. KIMURA, 1983 Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153: 163-168.
50. ITO, T., T. CHIBA, R. OZAWA, M. YOSHIDA, M. HATTORI et al., 2001 A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl. Acad. Sci. USA 98: 4569-4574.
51. KALPANA, G. V., S. MARMON, W. WANG, G. R. CRABTREE and S. P. GOFF, 1994 Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 266: 2002-2006.
52. KANG, X. L., F. YADAO, R. D. GIETZ and B. A. KUNZ, 1992 Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G/C to T/A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation. Genetics 130: 285-294.
53. KARST, S. M., N. SADEGHI and T. M. MENEES, 1999 Cell cycle control of reverse transcriptase activity for the yeast retrotransposon Ty3. Biochem. Biophys. Res. Commun. 254: 679-684.
54. KARST, S. M., M. RUTZ and T. MENEES, 2000 The yeast retrotransposons Ty1 and Ty3 require the RNA Lariat debranching enzyme, Dbr1p, for efficient accumulation of reverse transcripts. Biochem. Biophys. Res. Commun. 268: 112-117.
55. KASTANOS, E. K., Y. Y. WOLDMAN and D. R. APPLING, 1997 Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry 36: 14956-14964.
56. KATZMANN, D. J., G. ODORIZZI and S. D. EMR, 2002 Receptor down-regulation and multivesicular-body sorting. Nat. Rev. Mol. Cell Biol. 3: 893-905.
57. KIM, J. M., S. VANGURI, J. D. BOEKE, A. GABRIEL and D. F. VOYTAS, 1998 Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence. Genome Res. 8: 464-478.
58. KINSEY, P. T., and S. B. SANDMEYER, 1991 Adjacent pol II and pol III promoters: transcription of the yeast retrotransposon Ty3 and a target tRNA gene. Nucleic Acids Res. 19: 1317-1324.
59. KINSEY, P. T., and S. SANDMEYER, 1995 Ty3 transposes in mating populations of yeast: a novel transposition assay for Ty3. Genetics 139: 81-94.
60. KIRCHNER, J., C. M. CONNOLLY and S. B. SANDMEYER, 1995 Requirement of RNA polymerase III transcription factors for in vitro position-specific integration of a retroviruslike element. Science 267: 1488-1491.
61. KOOTSTRA, N. A., B. M. ZWART and H. SCHUITEMAKER, 2000 Diminished human immunodeficiency virus type 1 reverse transcription and nuclear transport in primary macrophages arrested in early G(1) phase of the cell cycle. J. Virol. 74: 1712-1717.
62. KROGAN, N. J., J. DOVER, A. WOOD, J. SCHNEIDER, J. HEIDT et al., 2003 The Pafl complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol. Cell 11: 721-729.
63. LEE, B. S., C. P. LICHTENSTEIN, B. FAIOLA, L. A. RINCKEL, W. WYSOCK et al., 1998 Posttranslational inhibition of Ty1 retrotransposition by nucleotide excision repair/transcription factor TFIIH subunits Ss12p and Rad3p. Genetics 148: 1743-1761.
64. LIEBMAN, S. W., and G. NEWNAM, 1993 A ubiquitin-conjugating enzyme, RAD6, affects the distribution of Ty1 retrotransposon integration positions. Genetics 133: 499-508.
65. LIN, S. S., M. H. NYMARK-MCMAHON, L. YIEH and S. B. SANDMEYER, 2001 Integrase mediates nuclear localization of Ty3. Mol. Cell. Biol. 21: 7826-7838.
66. MAERTENS, G., P. CHEREPANOV, W. PLUYMERS, K. BUSSCHOTS, E. DE CLERCQ et al., 2003 LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrate in human cells. J. Biol. Chem. 278: 33528-33539.
67. MATSUMOTO, K., I. UNO, Y. OSHIMA and T. ISHIKAWA, 1982 Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 79: 2355-2359.
68. MENEES, T. M., and S. B. SANDMEYER, 1994 Transposition of the yeast retroviruslike element Ty3 is dependent on the cell cycle. Mol. Cell. Biol. 14: 8229-8240.
69. MILLER, T., N. J. KROGAN, J. DOVER, H. ERDJUMENT-BROMAGE, P. TEMPST et al., 2001 COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc. Natl. Acad. Sci. USA 98: 12902-12907.
70. MOORE, S. P., L. A. RINCKEL and D. J. GARFINKEL, 1998 A Ty1 integrase nuclear localization signal required for retrotransposition. Mol. Cell. Biol. 18: 1105-1114.
71. NAKASHIMA, N., E. NOGUCHI and T. NISHIMOTO, 1999 Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152: 853-867.
72. ODORIZZI, G., D. J. KATZMANN, M. BABST, A. AUDHYA and S. D. EMR, 2003 Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J. Cell Sci. 116: 1893-1903.
73. OTT, D. E., 2002 Potential roles of cellular proteins in HIV-1. Rev. Med. Virol. 12: 359-374.
74. PIJNAPPEL, W. W., D. SCHAFT, A. ROGUEV, A. SHEVCHENKO, H. TEKOTTE et al., 2001 The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev. 15: 2991-3004.
75. PORNILLOS, O., J. E. GARRUS and W. I. SUNDQUIST, 2002 Mechanisms of enveloped RNA virus budding. Trends Cell Biol. 12: 569-579.
76. QIAN, Z., H. HUANG, J. Y. HONG, C. L. CURCK, S. D. JOHNSTON et al., 1998 Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Mol. Cell. Biol. 18: 4783-4792.
77. ROGUEV, A., D. SCHAFT, A. SHEVCHENKO, W. W. PIJNAPPEL, M. WILM et al., 2001 The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20: 7137-7148.
78. ROSS-MACDONALD, P., P. S. COELHO, T. ROEMER, S. AGARWAL, A. KUMAR et al., 1999 Large-scale analysis of the yeast genome by transposon tagging and gene disruption. Nature 402: 413-418.
79. ROUT, M. P., J. D. AITCHISON, A. SUPRAPTO, K. HJERTAAS, Y. M. ZHAO et al., 2000 The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148: 635-651.
80. SADEGHI, N., M.-L. RUIZ and T. M. MENEES, 2001 Thermal blockage of viruslike particle formation for the yeast retrotransposon Ty3 reveals differences in the cellular stress response. Arch. Virol. 146: 1919-1934.
81. SANDMEYER, S. B., M. AYE and T. M. MENEES, 2001 Ty3: a position-specific, gypsylike element in Saccharomyces cerevisiae, pp. 663-682 in Mobile DNA II, edited by N. L. CRAIG, R. CRAIGIE, M. GELLERT and A. M. LAMBOWITZ. ASM Press, Washington, DC.
82. SCARLATA, S., and C. CARTER, 2003 Role of HIV-1 Gag domains in viral assembly. Biochim. Biophys. Acta 1614: 62-72.
83. SCHOLES, D. T., M. BANERJEE, B. BOWEN and M. J. CURCIO, 2001 Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159: 1449-1465.
84. SCHRODER, A. R., P. SHINN, H. CHEN, C. BERRY, J. R. ECKER et al., 2002 HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110: 521-529.
85. SEIFERT, H. S., E. Y. CHEN, M. SO and F. HEFFRON, 1986 Shuttle mutagenesis: a method of transposon mutagenesis for Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 83: 735-739.
86. SHERMAN, F., G. R. FINK and J. B. HICKS, 1986 Laboratory Course Manual for Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
87. SINGLETON, T. L., and H. L. LEVIN, 2002 A long terminal repeat retrotransposon of fission yeast has strong preferences for specific sites of insertion. Eukaryot. Cell 1: 44-55.
88. STRACK, B., A. CALISTRI, S. CRAIG, E. POPOVA and H. G. GOTTLINGER, 2003 AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114: 689-699.
89. SUZUKI, Y., and R. CRAIGIE, 2002 Regulatory mechanisms by which barrier-to-autointegration factor blocks autointegration and stimulates intermolecular integration of Moloney murine leukemia virus preintegration complexes. J. Virol. 76: 12376-12380.
90. TOWERS, G. J., T. HATZIIOANNOU, S. COWAN, S. P. GOFF, J. LUBAN et al., 2003 Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. 9: 1138-1143.
91. TUCKER, M., R. R. STAPLES, M. A. VALENCIA-SANCHEZ, D. MUHLRAD and R. PARKER, 2002 Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO J. 21: 1427-1436.
92. VAN ARSDELL, S. W., G. L. STETLER and J. THORNER, 1987 The yeast repeated element sigma contains a hormone-inducible promoter. Mol. Cell. Biol. 7: 749-759.
93. VARMUS, H. E., T. PADGETT, S. HEASLEY, G. SIMON and J. M. BISHOP, 1977 Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell 11: 307-319.
94. VISINTIN, R., S. PRINZ and A. AMON, 1997 CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278: 460-463.
95. VON SCHWEDLER, U. K., M. STUCHELL, B. MULLER, D. M. WARD, H. Y. CHUNG et al., 2003 The protein network of HIV budding. Cell 114: 701-713.
96. VOYTAS, D. F., and J. D. BOEKE, 2002 Ty1 and Ty5 of Saccharomyces cerevisiae, pp. 631-683 in Mobile DNA II, edited by N. CRAIG, R. CRAIGIE, M. GELLERT and A. M. LAMBOWITZ. ASM Press, Washington, DC.
97. WACH, A., A. BRACHAT, R. POHLMANN and P. PHILIPPSEN, 1994 New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
98. WINZELER, E. A., D. D. SHOEMAKER, A. ASTROMOFF, H. LIANG, K. ANDERSON et al., 1999 Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285: 901-906.
99. WU, X., Y. LI, B. CRISE and S. M. BURGESS, 2003 Transcription start regions in the human genome are favored targets for MLV integration. Science 300: 1749-1751.
100. XIE, W., X. GAI, Y. ZHU, D. C. ZAPPULLA, R. STERNGLANZ et al., 2001 Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol. Cell. Biol. 21: 6606-6614.
101. XU, W., and A. P. MITCHELL, 2001 Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage. J. Bacteriol. 183: 6917-6923.
102. YIEH, L., G. KASSAVETIS, E. P. GEIDUSCHEK and S. B. SANDMEYER, 2000 The Brf and TATA-binding protein subunits of the RNA polymerase III transcription factor IIIB mediate position-specific integration of the gypsy-like element, Ty3. J. Biol. Chem. 275: 29800-29807.
103. ZACK, J. A., S. J. ARRIGO, S. R. WEITSMAN, A. S. GO, A. HAISLIP et al., 1990 HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61: 213-222.
104. ZIMMERMAN, C., K. C. KLEIN, P. K. KISER, A. R. SINGH, B. L. FIRESTEIN et al., 2002 Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature 415: 88-92.
105. ZOU, S., and D. F. VOYTAS, 1997 Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5. Proc. Natl. Acad. Sci. USA 94: 7412-7416.