Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus

Cancer Research

Volumn 64, Issue 24, 2004, Pages 8906-8910

  Kammerer, Stefan ^a   Roth, Richard B ^a   Reneland, Richard ^a   Marnellos, George ^a   Hoyal, Carolyn R ^a   Markward, Nathan J ^a   Ebner, Florian ^b   Kiechle, Marion ^c   Schwarz Boeger, Ulrike ^c   Griffiths, Lyn R ^d   Ulbrich, Christian ^e   Chrobok, Korbinian ^f   Forster, Gerhard ^e   Praetorius, Georg M ^e   Meyer, Peter ^g   Rehbock, Joachim ^b   Cantor, Charles R ^a   Nelson, Matthew R ^a   Braun, Andreas ^a  

^a SEQUENOM INC   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d GRIFFITH UNIVERSITY   (Australia)

^e Urologic Clinic Planegg   (Germany)

^f UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^g Genefinder Technologies Beteiligungs GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 4; INTERCELLULAR ADHESION MOLECULE 5; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME 19P; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 10844227446     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1788     Document Type: Article

References (41)

1. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
2. Welcsh PL, Owens KN, King MC. Insights into the functions of BRCA1 and BRCA2. Trends Genet 2000;16:69-74.
3. Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet 2003;33(Suppl):228-37.
4. Sing CF, Haviland MB, Reilly SL. Genetic architecture of common multifactorial diseases. Ciba Found Symp 1996;197:211-29; discussion 29-32.
5. Risch NJ. Searching for genetic determinants in the new millennium. Nature (Lond) 2000;405:847-56.
6. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science (Wash D C) 1996;273:1516-7.
7. Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science (Wash D C) 1997;278:1580-1.
8. Goldstein DB, Ahmadi KR, Weale ME, Wood NW. Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends Genet 2003;19:615-22.
9. Ozaki K, Ohnishi Y, Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002;32:650-4.
10. Carrasquillo MM, McCallion AS, Puffenberger EG, Kashuk CS, Nouri N, Chakravarti A. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat Genet 2002;32:237-44.
11. Kammerer S, Burns-Hamuro LL, Ma Y, et al. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci USA 2003;100:4066-71.
12. Buetow KH, Edmonson M, MacDonald R, et al. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci USA 2001;98:581-4.
13. Bansal A, van den Boom D, Kammerer S, et al. Association testing by DNA pooling: an effective initial screen. Proc Natl Acad Sci USA 2002;99:16871-4.
14. Nelson MR, Marnellos G, Kammerer S, et al. Large-scale validation of single nucleotide polymorphisms in gene regions. Genome Res 2004;14:1664-8.
15. Barratt BJ, Payne F, Rance HE, Nutland S, Todd JA, Clayton DG. Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Ann Hum Genet 2002;66:393-405.
16. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
17. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003;73:1162-9.
18. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-34.
19. Mohlke KL, Erdos MR, Scott LJ, et al. High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci USA 2002;99:16928-33.
20. Lopez-Otin C, Diamandis EP. Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr Rev 1998;19:365-96.
21. Frenette PS, Wagner DD. Adhesion molecules-Part 1. N Engl J Med 1996;334:1526-9.
22. O'Hanlon DM, Fitzsimons H, Lynch J, Tormey S, Malone C, Given HF. Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma. Eur J Cancer 2002;38:2252-7.
23. Kretowski A, Wawrusiewicz N, Mironczuk K, Mysliwiec J, Kretowska M, Kinalska I. Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease. J Clin Endocrinol Metab 2003;88:4945-9.
24. Matsuzawa J, Sugimura K. Matsuda Y, et al. Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population. Gut 2003;52:75-8.
25. Nejentsev S, Laaksonen M, Tienari PJ, et al. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol 2003;64:345-9.
26. Ogawa Y, Hirakawa K, Nakata B, et al. Expression of intercellular adhesion molecule-1 in invasive breast cancer reflects low growth potential, negative lymph node involvement, and good prognosis. Clin Cancer Res 1998;4:31-6.
27. Yasuda M, Tanaka Y, Tamura M, et al. Stimulation of beta1 integrin down-regulates ICAM-1 expression and ICAM-1-dependent adhesion of lung cancer cells through focal adhesion kinase. Cancer Res 2001;61:2022-30.
28. Maruo Y, Gochi A, Kaihara A, et al. ICAM-1 expression and the soluble ICAM-1 level for evaluating the metastatic potential of gastric cancer. Int J Cancer 2002;100:486-90.
29. Hubbard AK, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med 2000;28:1379-86.
30. Gardiner EE, D'Souza SE. Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis. J Biol Chem 1999;274:11930-6.
31. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-6.
32. Liu Y, Ludes-Meyers J, Zhang Y, et al. Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth. Oncogene 2002;21:7680-9.
33. Hermand P, Gane P, Huet M, et al. Red cell ICAM-4 is a novel ligand for platelet-activated alpha IIbbeta 3 integrin. J Biol Chem 2003;278:4892-8.
34. Yoshihara Y, Oka S, Nemoto Y, et al. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron 1994;12:541-53.
35. Tian L, Nyman H, Kilgannon P, et al. Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. J Cell Biol 2000;150:243-52.
36. Mizuno T, Yoshihara Y, Kagamiyama H, et al. Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. Brain Res 1999;849:58-66.
37. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003;33:177-82.
38. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-9.
39. Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG, Ioannidis JP. Establishment of genetic associations for complex diseases is independent of early study findings. Eur J Hum Genet 2004;12:762-9.
40. Cybulski C, Huzarski T, Gorski B, et al. A novel founder CHEK2 mutation is associated with increased prostate cancer risk. Cancer Res 2004;64:2677-9.
41. The CHEK2 Breast Cancer Case-Control Consortium. CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. Am J Hum Genet 2004;74:1175-82.