Structural constraints on protein self-processing in L-aspartate-α -decarboxylase

EMBO Journal

Volumn 22, Issue 23, 2003, Pages 6193-6204

  Schmitzberger, Florian ^a   Kilkenny, Mairi L ^a   Lobley, Carina M C ^a   Webb, Michael E ^b   Vinkovic, Mladen ^a,c   Matak Vinkovic, Dijana ^a,c   Witty, Michael ^a   Chirgadze, Dimitri Y ^a   Smith, Alison G ^a   Abel, Chris ^b   Blundell, Tom L ^a  

^a Department of Biochemistry ^*  (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

L aspartate decarboxylase; Oxyanion hole; Pyruvoyl dependent enzymes; Self processing

Indexed keywords

ALANINE; ASPARTATE ALPHA DECARBOXYLASE; CARBOXYLYASE; GLYCINE; HISTIDINE; OXAZOLIDINE DERIVATIVE; OXYOXAZOLIDINE; SERINE; THREONINE; UNCLASSIFIED DRUG; WATER;

ANALYTICAL ERROR; ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ALANINE; AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUTAMATE DECARBOXYLASE; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

INSERTION SEQUENCES;

EID: 10744232146     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg575     Document Type: Article

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