Synthesis of Mono- and Bisdihydrodipyridopyrazines and Assessment of Their DNA Binding and Cytotoxic Properties

Journal of Medicinal Chemistry

Volumn 47, Issue 4, 2004, Pages 978-987

  Blanchard, Stéphanie ^a   Rodriguez, Ivan ^a   Tardy, Christelle ^b   Baldeyrou, Brigitte ^b   Bailly, Christian ^b   Colson, Pierre ^c   Houssier, Claude ^c   Léonce, Stéphane ^e   Kraus Berthier, Laurence ^e   Pfeiffer, Bruno ^d   Renard, Pierre ^d   Pierré, Alain ^e   Caubère, Paul ^a   Guillaumet, Gérald ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c Nat and Synth Drugs Res Center   (Belgium)

^d ADIR   (France)

^e INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BISNAPHTHALIMIDE DERIVATIVE; CYTOTOXIC AGENT; DIHYDRODIPYRIDOPYRAZINE DERIVATIVE; DIMER; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; N1 [(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] N3 (DIMETHYL) 1,3 PROPANEDIAMINE; N1 [(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] N3 [3 [[(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL]AMINO]BUTYL] 1,3 PROPANEDIAMINE; N1 [(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] N3 [3 [[(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL]AMINO]PROPYL] 1,3 PROPANEDIAMINE; N1 [(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] N4 (DIMETHYL) 1,4 BUTANEDIAMINE; N1,N3 BIS[(5,10 DIMETHYL 5,10 DIHYDROPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] 1,3 PROPANEDIAMINE; N1,N4 BIS[[[(5,10 DIMETHYL 5,10 DIHYDRODIPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL]AMINO]PROPYL] 1,4 BUTANEDIAMINE; N1,N7 BIS[(5,10 DIMETHYL 5,10 DIHYDROPYRIDO[2,3 B:3,2 E]PYRAZIN 2 YL)METHYL] 1,7 HEPTANEDIAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA SEQUENCE; DRUG SCREENING; DRUG SYNTHESIS; LEUKEMIA CELL; LINEAR DICHROISM; MOUSE; MURINE LEUKEMIA; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DIHYDROPYRIDINES; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, SUPERHELICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTERCALATING AGENTS; LEUKEMIA P388; MICE; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744229648     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0309351     Document Type: Article

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