Design of new anticancer drugs. I. Easy hetarynic access to dihydrodipyridopyrazines, a new family of antitumor agents

Tetrahedron Letters

Volumn 39, Issue 40, 1998, Pages 7283-7286

  Rodriguez, Ivan ^a   Kuehm Caubère, Catherine ^b   Vinter Pasquier, Karine ^a   Renard, Pierre ^b   Pfeiffer, Bruno ^b   Caubère, Paul ^a,c  

^a CNRS   (France)

^b ADIR   (France)

^c UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PYRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; CYCLIZATION; CYTOTOXICITY; DIMERIZATION; DRUG SYNTHESIS; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; X RAY DIFFRACTION;

EID: 0032191534     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01558-5     Document Type: Article

References (12)

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2. 1. See for example: Pratt, W.B.; Ruddon, R;W.; Ensminger, W.D.; Maybaum, J. The Anticancer Drugs (second edition), Oxford University Press, 1994. Wang, H.-K.; Lee, K.-H. Bot. Bull. Acad. Sin. 1997, 38, 225-235. Armand, J.-P. Jpn Cancer Chemother. (Suppl. I), 1997, 24, 70-93. Kikpatrick, D.L. Current Pharmaceutical Design 1997, 3, 305-322 and ref. cited in these reviews.
3. 1. See for example: Pratt, W.B.; Ruddon, R;W.; Ensminger, W.D.; Maybaum, J. The Anticancer Drugs (second edition), Oxford University Press, 1994. Wang, H.-K.; Lee, K.-H. Bot. Bull. Acad. Sin. 1997, 38, 225-235. Armand, J.-P. Jpn Cancer Chemother. (Suppl. I), 1997, 24, 70-93. Kikpatrick, D.L. Current Pharmaceutical Design 1997, 3, 305-322 and ref. cited in these reviews.
4. 1. See for example: Pratt, W.B.; Ruddon, R;W.; Ensminger, W.D.; Maybaum, J. The Anticancer Drugs (second edition), Oxford University Press, 1994. Wang, H.-K.; Lee, K.-H. Bot. Bull. Acad. Sin. 1997, 38, 225-235. Armand, J.-P. Jpn Cancer Chemother. (Suppl. I), 1997, 24, 70-93. Kikpatrick, D.L. Current Pharmaceutical Design 1997, 3, 305-322 and ref. cited in these reviews.
5. 2. Vinter-Pasquier, K.; Jamart-Grégoire, B.; Caubère, P. Heterocycles 1997, 45, 2113-2129. Vinter-Pasquier, K. Thèse d'Université, Nancy, France, 1996.
6. 3. Caubère, P. Reviews on Heteroatom Chemistry 1991, 4, 78-139. Caubère, P. Chem. Rev. 1993, 93, 2317-2334.
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10. 4 and the solvent evaporated under vacuum. The residue was flash chromatographed on silica using ethyl acetate-hexane (1/49) as eluent.
11. 6. Marquet, A.; Jacques, J. Bull. Soc. Chim. Fr. 1962, 90. Marquet, A.; Jacques, J.; Tchoubar, B. Bull. Soc. Chim. Fr. 1965, 511-518.
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