Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463

Cytokine

Volumn 9, Issue 11, 1997, Pages 837-845

  Wagner, Tamara L ^a   Horton, Vicki L ^a   Carlson, Gary L ^a   Myhre, Paula E ^a   Gibson, Sheila J ^a   Imbertson, Linda M ^a   Tomai, Mark A ^a  

^a 3M COMPANY   (United States)

Author keywords

Cytokine; Immune response modifiers; Immunomodulators; Interferon; Interleukin

Indexed keywords

CYTOKINE; IMIQUIMOD; MESSENGER RNA;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD LEVEL; GUINEA PIG; IMMUNE RESPONSE; IMMUNOMODULATION; MONKEY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SKIN BIOPSY;

CAVIA PORCELLUS; MACACA FASCICULARIS; SUS SCROFA;

EID: 0031282514     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1997.0239     Document Type: Article

References (26)

1. 1. Miller RL, Imbertson LM, Reiter MJ, Schwartzmiller DH, Pecore SE, Gerster JF (1985) Inhibition of herpes simplex virus infection in a guinea pig model by S-26308. ASM Interscience Conference on Antimicrob Agents Chemother 235.
2. 2. Harrison CJ, Jenski L, Voychehovski T, Bernstein DI (1988) Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Res 10:209-224.
3. 3. Bernstein DI, Harrison CJ (1989) Effects of the immunomodulating agent R-837 on acute and latent herpes simplex virus type 2 infections. Antimicrob Agents Chemother 33:1511-1515.
4. 4. Harrison CJ, Stanberry LR, Bernstein DI (1991) Effects of cytokines and R-837, a cytokine inducer, on UV-irradiation augmented recurrent genital herpes in guinea pigs. Antiviral Res 15:315-322.
5. 5. Bernstein DI, Miller RL, Harrison CJ (1993) Effects of the immunomodulators (imiquimod, R-837) alone and with acyclovir on genital HSV-2 infection in guinea pigs when begun after lesion development. Antiviral Res 20:45-55.
6. 6. Tomai MA, Gibson SJ, Imbertson LM, Miller RL, Myhre PE, Reiter MJ, Wagner TL, Tamulinas CB, Beaurline JM, Gerster JF, Horton VL (1995) Immunomodulating and antiviral activities of the imidazoquinoline S-28463. Antiviral Res 28:253-264.
7. 7. Chen M, Griffith BP, Lucia HL, Hsuing GD (1988) Efficacy of S-26308 against guinea pig cytomegalovirus. Antimicrob Agents Chemother 32:678-678.
8. 8. Kende M, Lupton HW, Canonico PG (1988) Treatment of experimental viral infections with immunomodulators. Adv Biosciences 68:51-63.
9. 9. Sidky YA, Borden EC, Weeks CE, Reiter MJ, Hatcher JF, Bryan GT (1992) Inhibition of murine tumor growth by an interferon inducing imidazoquinoline. Cancer Res 52:3528-3533.
10. 10. Borden EC, Sidky YA, Weeks CE (1991) Mechanisms of anti-tumor action of the interferon inducer R-837. Proc Amer Assoc Cancer Res 32:258.
11. 11. Baca LM, Genis P, Kalvakolanu D, Ganes S, Meltzer MS, Zhou A, Silverman R, Gendelman HE (1994) Regulation of interferon-α-inducible cellular genes in human immunodeficiency virus-infected monocytes. J Leuk Biol 55:299-309.
12. 12. Weeks CE, SJ Gibson (1993) Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro. J Interferon Res 14:81-85.
13. 13. Testerman TL, Gerster JF, Imbertson LM, Reiter MJ, Miller RL, Gibson SJ, Wagner TL, Tomai MA (1995) Cytokine induction by the immunomodulators imiquimod and S-27609. J Leuk Biol 58:365-372.
14. 14. Megyeri K, Au W-C, Rosztoczy I, Raj NBK, Miller RL, Tomai MA, Pitha PM (1995) Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways. Mol Cell Biol 15:2207-2218.
15. 15. Gibson SJ, Imbertson LM, Wagner TL, Testerman TL, Reiter MJ, Miller RL, Tomai MA (1995) Cellular requirements for cytokine production in response to the immunomodulators imiquimod and S-27609. J Interferon Res 15:537-545.
16. 16. Reiter MJ, Testerman TL, Miller RL, Weeks CE, Tomai MA (1994) Cytokine induction in mice by the immunomodulators imiquimod. J Leuk Biol 55:234-240.
17. 17. Kono MD, Kondo S, Pastore S, Shivji GM, Tomai MA, McKenzie RC, Sauder DN (1993) Effects of a novel immunomodulators, imiquimod, on keratinocyte cytokine gene expression. Lymphokine Cytokine Res 13:71-76.
18. 18. Fujisawa H, Shivji GM, Kondo S, Wang B, Tomai MA, Miller RL, Sauder DN (1996) Effect of a novel topical immunomodulator, S-28463, on keratinocyte cytokine gene expression and production. J Interferon Res 16:555-559.
19. 19. Verdier F, Aujoulat M, Conevaux F, Descotes J (1995) Determination of lymphocyte subsets and cytokine levels in cynomolgus monkeys. Toxicology 105:81-90.
20. 20. Villinger F, Hunt D, Mayne A, Vuchetich M, Findley H, Ansari AA (1993) Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells. Cytokine 5:469-479.
21. 21. Benveniste O, Vaslin B, Villinger F, Le Grand R, Ansari A, Dormont D (1996) Cytokine mRNA levels in unmanipulated (ex vivo) and in vitro stimulated monkey PBMCs using a semi-quantitative RT-PCR and high sensitivity fluorescence-based detection strategy. Cytokine 8:32-41.
22. 22. Horisberger MA, Zeller H, Goetschy JF, Von Wussow P, Hochkeppel HK (1987) Induction of human p78 protein (homologue of the mouse MxA protein) by rIFN-α and γ, alone or in combination: studies in vitro and during IFN therapy. J Interferon Res 7:719.
23. 23. Liberati AM, Horisberger MA, Palisano L, Astolfi S, Nastari A, Mechati S, Villa A, Mancini S, Arzano S, Grignani F (1992) Double-blind randomized phase 1 clinical tolerance and biological effects of natural and recombinant interferon-β. J Interferon Res 12:329-336.
24. 24. Borden E, Witt P, Kvam D, Wick K, Ritch P, Anderson T, Owens M, Sidky Y, Grossberg S (1991) An effective oral inducer of interferons in humans. J Interferon Res 11:(Suppl.1):S92.
25. 25. Wick KA, Kvam DC, Weeks CE, Dixon RM, Hafstad K, Witt PL (1991) Oral R-837 induces interferon in healthy volunteers. Proc Amer Assoc Cancer Res 32:257.
26. 26. Imbertson LM, Weeks C, Adams N, McCarville S, Finley D, Holtzman J, Miller RL, Kvam D (1992) Induction of antiviral activity and cytokines by oral imiquimod in healthy volunteers. J Interferon Res 12:S127.