New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 23, 2003, Pages 4209-4212

  Singh, Upinder ^a   Raju, B ^a   Lam, Stuart ^a   Zhou, Joseph ^a   Gadwood, Robert C ^b   Ford, Charles W ^b   Zurenko, Gary E ^b   Schaadt, Ronda D ^b   Morin, Sara E ^b   Adams, Wade J ^b   Friis, Janice M ^b   Courtney, Maria ^b   Palandra, Joe ^b   Hackbarth, Corinne J ^a   Lopez, Sara ^a   Wu, Charlotte ^a   Mortell, Kathleen H ^a   Trias, Joaquim ^a   Yuan, Zhengyu ^a   Patel, Dinesh V ^a   Gordeev, Mikhail F ^a   more..

^a Vicuron Pharmaceuticals   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; BENZAMIDE DERIVATIVE; LINEZOLID; OXAZOLIDINONE DERIVATIVE; THIOMORPHOLINE DERIVATIVE; THIOPYRAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG ACETYLATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; MALE; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; RESPIRATORY TRACT INFECTION; SEPTICEMIA; SOLID;

HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; MORAXELLA CATARRHALIS;

EID: 10744227506     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.07.022     Document Type: Article

References (20)

1. Low D.E., Willey B.M., McGeer A.J. Am. J. Surg. 5A:1995;8S.
2. Spera R.V. Jr., Farber B.F. Drugs. 48:1994;678.
3. Brumfitt W., Hamilton-Miller J.M.T. Drugs Exp. Clin. Res. 1994;215.
4. Hiramatsu K., Hanaki H., Ino T., Yabuta K., Oguri T., Tenover F.C. J. Antimicrob. Chemother. 40:1997;135.
5. Waldvogel F.A. N. Engl. J. Med. 340:1999;556.
6. Gibson G.E., Shinabarger J.K., Aristoff D.L., Ford P.A., Tarpley C.F.W.G. Curr. Opin. Pharm. 1:2001;470.
7. Gadwood, R. C. and Shinabarger, D. A. Annual Reports in Medicinal Chemistry; Academic: San Diego, 2000; p 135.
8. Gordeev M.F. Curr. Opin. Drug Disc. Develop. 4:2001;450.
9. Thompson J., O'Connor M., Mills J.A., Dahlberg A.E. J. Mol. Biol. 322:2002;273. and references therein.
10. Lizondo J., Rabasseda X., Castañer J. Drugs Future. 21:1996;1116.
11. Brickner S. J. Curr. Pharma. Des. 2:1996;175.
12. Poel, T. J.; Thomas, R. C.; Barbachyn, M. R.; Ford, C. W.; Zurenko, G. E.; Adams, W. J.; Sims, S. M.; Watt, W.; Dolak, L. A. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francsico, 1999; Abstract 568.
13. Gregory W.A., Brittelli D.R., Wang C.L., Wuonola M.A., McRipley R.J., Eustice D.C., Eberly V.S., Bartholomew P.T., Slee A.M., Forbes M. J. Med. Chem. 32:1989;1673.
14. Tokuyama R., Takahashi Y., Tomita Y., Suzuki T., Yoshida T., Iwasaki N., Kado N., Okezaki E., Nagata O. Chem. Pharm. Bull. 49:2001;347.
15. Tokuyama R., Takahashi Y., Tomita Y., Suzuki T., Yoshida T., Iwasaki N., Kado N., Okezaki E., Nagata O. Chem. Pharm. Bull. 49:2001;353.
16. Tokuyama R., Takahashi Y., Tomita Y., Suzuki T., Yoshida T., Iwasaki N., Kado N., Okezaki E., Nagata O. Chem. Pharm. Bull. 49:2001;361.
17. Libraries were prepared using custom-made all-teflon 96-well plates or Quest 210 synthesizer.
18. 1H NMR and their yields were estimated using tBuOH as an internal standard. Analogues were prepared in four libraries: 226 amides, 20 ureas, 22 thiourea, 11 carbamate.
19. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grows Aerobically, 4th ed.; Approved standards: NCCLS Document M7-A4; National Committee for Clinical Laboratory Standards: Villanova, PA, USA, 1997.
20. Ford C.W., Hamel J.C., Wilson D.M. Antimicrob. Agents Chemother. 40:1996;1508.