Linezolid: Oxazolidinone antibacterial

Drugs of the Future

Volumn 21, Issue 11, 1996, Pages 1116-1123

  Lizondo, J ^a   Rabasseda, X ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; CLINDAMYCIN; LINEZOLID; METICILLIN; OXAZOLIDINE DERIVATIVE; PIPERACILLIN; TAZOBACTAM; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; BACTERIAL INFECTION; BACTEROIDES FRAGILIS; CONTROLLED STUDY; CORYNEBACTERIUM; DRUG RESISTANCE; DRUG SYNTHESIS; ENTEROBACTER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; SHORT SURVEY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0030455057     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.11.383118     Document Type: Article

References (35)

1. Brickner, S.J., Hutchinson, D.K., Barbachyn, M.R. et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant Gram-positive bacterial infections. J Med Chem 1996, 39: 673-9.
2. Barbachyn, M.R., Brickner, S.J., Hutchinson, D.K. (The Upjohn Co.). Substd. oxazine and thiazine oxazolidinone antimicrobials. EP 717738, WO 9507271.
3. Fugitt, R.B., Luckenbaugh, R.W. (E.I. Du Pont de Nemours and Co.). 5-Halomethyl-3-phenyl-2-oxazolidinones. US 4128654.
4. Gregory, W.A. (E.I. DuPont de Nemours and Co.). p-Oxooxazolidinylbenzene cpds. as antibacterial agents. US 4461773.
5. Daly, U.S., Eliopoulos, G.M., Willey, S., Moellering, R.C. Jr. Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compound. Antimicrob Agents Chemother 1988, 32: 1341-6.
6. Gregory, W.A., Brittelli, D.R., Wang, C.L., Wuonola, M.A., McRipley, R.J., Eustice, D.C., Eberly, V.S., Bartholomew, P.T., Slee, A.M., Forbes, M. Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. J Med Chem 1989, 32: 1673-81.
7. Gregory, W.A. (E.I. Du Pont de Nemours and Co.). Aminomethyloxooxazolidinyl benzene derivs. useful as antibacterial agents. EP 127907, ES 8506659, ES 8802037, JP 85008277, US 4705799.
8. Slee, A.M., Wuonola, M.A., McRipley, R.J., Zajac, I., Zawada, M.J., Bartholomew, P.T., Gregory, W.A., Forbes, M. Oxazolidinones, a new class of synthetic antibacterials: In vitro and in vivo activities of DuP 105 and DuP 721. 27th Intersci Conf Antimicrob Agents Chemother (Oct 4-7, New York) 1987, Abst 244.
9. Slee, A.M., Wuonola, M.A., McRipley, R.J., Zajac, I., Zawada, M.J., Bartholomew, P.T., Gregory, W.A., Forbes, M. Oxazolidinones, a new class of synthetic antibacterial agents: In vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob Agents Chemother 1987, 31: 1791-7.
10. Ashtekar, D.R., Costa-Pereira, R., Shrinivasan, T., Iyyer, R., Vishvanathan, N., Rittel, W. Oxazolidinones, a new class of synthetic antituberculosis agent. Diagn Microbiol Infect Dis 1991, 14: 465-71.
11. Brumfitt, W., Hamilton-Miller, J. In vitro activity of DuP 105 and 721, new synthetic antimicrobial agents. 27th Intersci Conf Antimicrob Agents Chemother (Oct 4-7, New York) 1987, Abst 241.
12. Hutchinson, D.K., Barbachyn, M.R., Brickner, S.J. et al. Structure-activity relationships of piperazinylphenyl oxazolidinone antibacterial agents and related developments. 212th ACS Natl Meet (Aug 25-29, Orlando) 1996, Abst MEDI 192.
13. Zurenko, G.E., Yagi, B.H., Schaadt, R.D., Allison, J.W., Kilburn, J.O., Glickman, S.E., Hutchinson, D.K., Barbachyn, M.R., Brickner, S.J. In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents. Antimicrob Agents Chemother 1996, 40: 839-45.
14. Jones, R.N., Johnson, D.M., Erwin, M.E. In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones. Antimicrob Agents Chemother 1996, 40: 720-6.
15. Kaatz, G.W., Seo, S.M. In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 1996, 40: 799-801.
16. Eliopoulos, G.M., Wennersten, C.B., Gold, H.S., Moellering, R. C. Jr. In vitro activities of new oxazolidinone antimicrobial agents against enterococci. Antimicrob Agents Chemother 1996, 40: 1745-7.
17. Spangler, S.K., Jacobs, M.R., Appelbaum, P.C. Activities of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new Oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents against 203 penicillin-susceptible and -resistant pneumococci. Antimicrob Agents Chemother 1996, 40: 481-4.
18. Mulazimoglu, L., Drenning, S.D., Yu, V.L. In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinoline (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 1996, 40: 2428-30.
19. Watts, J.L., Salmon, S.A., Yancey, R.J. Jr., Ford, C.W. In vitro activity of two oxazolidinone antimicrobial agents (U-100592 and U-100766) against Mycoplasma spp. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F220.
20. Jenkins, S.G., Lewis, J.W. Comparative in vitro activities of vancomycin and the oxazolidinones U-100592 and U-100766 against 300 clinical staphylococcal isolates. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F213.
21. Nepomuceno, J., Case, M., Pachucki, C., Lentino, J.R. In vitro activity of Oxazolidinones U-100592 and U-100766 against thirty-five isolates of vancomycin resistant enterococci. 36th Intersci Conf Antimicrob Agents Chemother (Sept 15-18, New Orleans) 1996, Abst F231.
22. Mason, E.O. Jr., Lamberth, L.B., Kaplan, S.L. Activity of oxazolidinones U-100592 and U-100766 in vitro against penicillin-resistant and cephalosporin-resistant strains of S. pneumoniae. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F212.
23. Jorgensen, J.H., McElmeel, M.L., Trippy, C.W. In vitro activities of U-100592 and U-100766 against Staphyloccccus aureus and coagulase-negative species of Staphylococcus. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F214.
24. Spangler, S.K., Jacobs, M.R., Appelbaum, P.C. Susceptibility of 115 penicillin susceptible and resistant pneumococci to two oxazolidinones compared to penicillin G, ceftriaxone, teicoplanin, vancomycin, rifampin and imipenem. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F218.
25. Bostic, G., Perri, M.B., Thal, L.A., Zervos, M.J. Comparative invitro and bactericidal activity of oxazolidinone antibiotics against multi-drug resistant enterococci. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F219.
26. Worth, S., Erwin, M.E., Jones, R.N. et al. Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithmmycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Results from multicenter trials. Diagn Microbiol Infect Dis 1996, 24: 87-91.
27. Ford, C.W., Hamel, J.C., Wilson, D.M., Moerman, J.K., Stapert, D., Yancey, R.J. Jr., Hutchinson, D.K., Barbachyn, M.R., Brickner, S.J. In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob Agents Chemother 1996, 40: 1508-13.
28. Zurenko, G., Ford, C., Brickner, S., Barbachyn, M., Hutchinson, D. In vitro and in vivo activity of U-100592 and U-100766, novel oxa-zolidinone antimicrobial agents. 1st Eur Cong Chemother (May 14-17, Glasgow) 1996, Abst F150.
29. Ford, C.W, Hamel, J.C., Moerman, J.K., Stapert, D., Wilson, D.M., Yancey, R.J., Barbachyn, M.R., Hutchinson, D.K., Brickner, S.J. In vitro efficacy evaluations of U-100592 and U-100766, new oxazolidinone antibiotics. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F221.
30. Zamkoff, J.P., Cline, K., Klemens, S.P., Cynamon, M.H. Activity of U-100480, an oxazolidinone, against M. avium complex (MAC) infection in beige mice. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F229.
31. Klemens, S.P., Sharpe, C.A., Cynamon, M.H. Activities of two novel oxazolidinones against M. tuberculosis (MTB) in a murine model. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F228.
32. Hamel, J.C., Stapert, D., Moerman, J.K., Ford, C.W. Experimental therapy of monomicrobic and polymicrobic soft tissue infections with U-100766 and U-100592, two new oxazolidinone antibiotics. 36th Intersci Conf Antimicrob Agents Chemother (Sept 15-18, New Orleans) 1996, Abst F232.
33. Koike, S., Miura, H., Nakamura, R., Chiba, K., Moe, J.B. Drug safety studies with a novel oxazolidinone, U-100766.35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F224.
34. Pawsey, S.D., Daley-Yates, P.T., Wajszczuk, C.P., Stalker, D.J. U-100766 safety, toleration and pharmacokinetics after oral and intravenous (IV) administration. 1st Eur Cong Chemother (May 14-17, Glasgow) 1996, Abst F151.
35. Schaadt, R.D., Batts, D.H., Pawsey, S.D., Daley-Yates, P.T., Stalker, D.J., Zurenko, G.E. Serum inhibitory titers (SIT) and serum bactericidal titers (SBT) for human subjects receiving multiple doses of the antibacterial oxazolidinones U-100592 (592) and U-100766 (766). 36th Intersci Conf Antimicrob Agents Chemother (Sept 15-18, New Orleans) 1996, Abst F234.