In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy

Gene Therapy

Volumn 10, Issue 25, 2003, Pages 2098-2103

  Le Gat, L ^a   Gogat, K ^a   Bouquet, C ^b   Saint Geniez, M ^c   Darland, D ^c   Van Den Berghe, L ^a   Marchant, D ^a   Provost, A ^a   Perricaudet, M ^b   Menasche, M ^a   Abitbol, M ^a  

^a Institut Necker   (France)

^b CNRS   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adenovirus; Endostatin; Retinal neovascularization; Urokinase

Indexed keywords

ADENOVIRUS VECTOR; ENDOSTATIN; HUMAN SERUM ALBUMIN; PLASMINOGEN ACTIVATOR INHIBITOR; UROKINASE; UROKINASE RECEPTOR; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG HALF LIFE; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA NEOVASCULARIZATION; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; VISUAL IMPAIRMENT;

ADENOVIRUSES, HUMAN; ANGIOGENESIS INHIBITORS; ANIMALS; ENDOSTATINS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; INJECTIONS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PEPTIDE FRAGMENTS; RETINAL NEOVASCULARIZATION; SERUM ALBUMIN; URINARY PLASMINOGEN ACTIVATOR; VITREOUS BODY;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 10744226511     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302122     Document Type: Article

References (29)

1. Kahn HA, Hiller R. Blindness caused by diabetic retinopathy. Am J Ophthalmol 1974; 78: 58-67.
2. Aiello LP. Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies. Ophthal Res 1997; 29: 354-362.
3. Raisler BJ et al. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci USA 2002; 99: 8909-8914.
4. Bainbridge JW et al. Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. Gene Therapy 2002; 9: 320-326.
5. Bainbridge JW, Mistry AR, Thrasher AJ, Ali RR. Gene therapy for ocular angiogenesis. Clin Sci (Lond) 2003; 104: 561-575.
6. Pollanen J, Stephens RW, Vaheri A. Directed plasminogen activation at the surface of normal and malignant cells. Adv Cancer Res 1991; 57: 273-328.
7. Ribatti D et al. In vivo angiogenic activity of urokinase: role of endogenous fibroblast growth factor-2. J Cell Sci 1999; 112: 4213-4221.
8. Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993; 4: 1317-1326.
9. Kobayashi H et al. Inhibition of tumor cell invasion through matrigel by a peptide derived from the domain II region in urinary trypsin inhibition. Cancer Res 1995; 55: 1847-1852.
10. Li H et al. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Therapy 1998; 5: 1105-1113.
11. Li H et al. Systemic delivery of antiangiogenic adenovirus AdmATF induces liver resistance to metastasis and prolongs survival of mice. Hum Gene Ther 1999; 10: 3045-3053.
12. Wickstrom SA et al. Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells. Cancer Res 2001; 61: 6511-6516.
13. O'Reilly MS et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-285.
14. Dhanabal M et al. Cloning, expression, and in vitro activity of human endostatin. Biochem Biophys Res Commun 1999; 258: 345-352.
15. Auricchio A et al. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Mol Ther 2002; 6: 490-494.
16. Mori K et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol 2001; 188:253-263.
17. Dhanabal M et al. Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. Cancer Res 1999; 59: 189-197.
18. Dhanabal M et al. Endostatin induces endothelial cell apoptosis. J Biol Chem 1999; 274: 11721-11726.
19. Smith LE et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35: 101-111.
20. Apparailly F et al. Adenovirus-mediated gene transfer of urokinase plasminogen inhibitor inhibits angiogenesis in experimental arthritis. Gene Therapy 2002; 9: 192-200.
21. Yamaguchi N et al. Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J 1999; 18: 4414-4423.
22. Pierce EA et al. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 1995; 92: 905-909.
23. Hellstrom A et al. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci USA 2001; 98: 5804-5808.
24. Nadal JA, Scicli GM, Carbini LA, Scicli AG. Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-beta and PDGF-BB. Am J Physiol Heart Circ Physiol 2002; 282: H739-H748.
25. Ozaki H et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol 2000; 156: 697-707.
26. Carter DC, Ho JX. Structure of serum albumin. Adv Protein Chem 1994; 45: 153-203.
27. Stehle G et al. Albumin-based drug carriers: comparison between serum albumins of different species on pharmacokinetics and tumor uptake of the conjugate. Anticancer Drugs 1999; 10: 785-790.
28. Yeh P et al. Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate. Proc Natl Acad Sci USA 1992; 89: 1904-1908.
29. Crouzet J et al. Recombinational construction in Escherichia coli of infectious adenoviral genomes. Proc Natl Acad Sci USA 1997; 94: 1414-1419.