Adenovirus-mediated gene transfer of urokinase plasminogen inhibitor inhibits angiogenesis in experimental arthritis

Gene Therapy

Volumn 9, Issue 3, 2002, Pages 192-200

  Apparailly, F ^a   Bouquet, C ^c   Millet, V ^a   Noel, D ^a   Jacquet, C ^a   Opolon, P ^c   Perricaudet, M ^c   Sany, J ^a,b   Yeh, P ^c   Jorgensen, C ^a,b  

^a INSERM   (France)

^b LAPEYRONIE HOSPITAL   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Adenovirus; Angiogenesis; Arthritis; ATF; Gene therapy

Indexed keywords

ADENOVIRIDAE; ANIMALS; ANTIBODIES; ARTHRITIS, EXPERIMENTAL; GENE THERAPY; GENETIC VECTORS; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED DBA; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

ACTIN; ADENOVIRUS VECTOR; COLLAGEN; HUMAN SERUM ALBUMIN; METALLOPROTEINASE; PLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR; UROKINASE RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CELL MIGRATION; CHIMERA; CONTROLLED STUDY; DISEASE SEVERITY; DRUG HALF LIFE; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR BINDING; SMOOTH MUSCLE; SYNOVIOCYTE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 85047698158     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301628     Document Type: Article

References (27)

1. Review: Angiogenesis: Implications for rheumatoid arthritis
2. Starving the synovium: Angiogenesis and inflammation in rheumatoid arthritis
3. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
4. Effects of combinations of anti-rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis
5. Imbalance in production between vascular endothelial growth factor and endostatin in patients with rheumatoid arthritis
6. Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist
7. Angiogenesis inhibition suppresses collagen arthritis
8. Suppression of collagen-induced arthritis by an angiogenesis inhibitor, AGM-1470, in combination with cyclosporin: Reduction of vascular endothelial growth factor (VEGF)
9. Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis
10. Differential expression of the urokinase receptor (CD87) in arthritic and normal synovial tissues
11. Directed plasminogen activation at the surface of normal and malignant cells
12. Upregulation of urokinase receptor expression on migrating endothelial cells
13. Plasminogen activation in synovial tissues: Differences between normal, osteoarthritis, and rheumatoid arthritis joints
14. Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro
15. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice
16. Systemic delivery of antiangiogenic adenovirus AdmATF induces liver resistance to metastasis and prolongs survival of mice
17. Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice
18. Angiogenesis and arthritis
19. Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis
20. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor
21. Albumin-based drug carriers: Comparison between serum albumins of different species on pharmacokinetics and tumor uptake of the conjugate
22. Structure of serum albumin
23. Design of yeast-secreted albumin derivatives for human therapy: Biological and antiviral properties of a serum albumin-CD4 genetic conjugate
24. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
25. Recombinational construction in Escherichia coli of infectious adenoviral genomes
26. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation
27. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis