Structural, Functional and Autonomic Changes in the Cardiovascular System in Growth Hormone Deficient Patients

Annals of Noninvasive Electrocardiology

Volumn 9, Issue 1, 2004, Pages 19-23

  Erdoǧan, Doǧan ^a   Tükek, Tufan ^a,c   Aral, Ferihan ^a   Oflaz, Hüseyin ^a   Özaydin, Mehmet ^b   Kocaman, Orhan ^a   Akkaya, Vakur ^a   Gören, Taner ^a   Molvalilar, Senay ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^c Seyit Ömer Cami Sokak ^*  (Turkey)

Author keywords

Autonomic dysfunction; Growth hormone deficiency; Heart rate variability

Indexed keywords

ADULT; ARTERY DIAMETER; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BODY MASS; BODY SURFACE; CARDIOVASCULAR SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPHY; EXERCISE TEST; FEMALE; GROWTH HORMONE DEFICIENCY; HEART EJECTION FRACTION; HEART LEFT VENTRICLE; HEART RATE VARIABILITY; HEART VENTRICLE EJECTION; HEIGHT; HUMAN; MALE; MORTALITY; PRIORITY JOURNAL; SYMPATHETIC NERVE; SYSTOLIC BLOOD PRESSURE; WEIGHT;

AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR SYSTEM; CASE-CONTROL STUDIES; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY, AMBULATORY; EXERCISE TEST; FEMALE; HEART RATE; HUMAN GROWTH HORMONE; HUMANS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 10744226423     PISSN: 1082720X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1542-474X.2004.91521.x     Document Type: Article

References (21)

1. Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990;336:285-288.
2. Sacca L, Cittadini A, Fazio S. Growth hormone and the heart. Endocr Rev 1994;15(5):555-573.
3. Shahi M, Beshyah SA, Hackett D, et al. Myocardial dysfunction in treated adult hypopituitarism: A possible explanation for increased cardiovascular mortality. Br Heart J 1992;67(1):92-96.
4. Longobardi S, Cuocolo A, Merola B, et al. Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency. Clin Endocrinol (Oxf) 1998;48(2):137-143.
5. Merola B, Cittadini A, Colao A, et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. Clin Endocrinol Metab 1993;77(6):1658-1661.
6. Cuocolo A, Nicolai E, Colao A, et al. Improved left ventricular function after growth hormone replacement In patients with hypopituitarism: assessment with radionuclide angiography. Eur J Nucl Med 1996;23(4):390-394.
7. Sartorio A, Ferrero S, Conti A, et al. Adults with childhood-onset growth hormone deficiency: Effects of growth hormone treatment on cardiac structure. J Intern Med 1997;241(6):515-520.
8. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measurement, physiological interpretation and clinicial use. Eur Heart J 1996;17:354-381.
9. Bilchick KC, Fetics B, Djoukeng R, et al. Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure). Am J Cardiol 2002 1; 90:24-28.
10. Lanza GA, Guido V, Galeazzi MM, et al. Prognostic role of heart rate variability in patients with a recent acute myocardial infarction. Am J Cardiol 1998;82(11):1323-1328.
11. Leong KS, Mann P, Wallymahmed M, et al. Abnormal heart rate variability in adults with growth hormone deficiency. J Clin Endocrinol Metab 2000;85(2):628-633.
12. Leong KS, Mann P, Wallymahmed M, et al. The influence of growth hormone replacement on heart rate variability in adults with growth hormone deficiency. Clin Endocrinol (Oxf) 2001;54(6):819-826.
13. Bisi G, Podio V, Valetto MR, et al. Radionuclide angiocardiographic evaluation of the cardiovascular effects of recombinant human IGF-I in normal adults. Eur J Endocrinol 1999;140(4):322-327.
14. Volterrani M, Manelli F, Cicoira M, et al. Role of growth hormone in chronic heart failure. Therapeutic implications. Drugs. 2000;60(4):711-719.
15. Lombardi G, Di Somma C, Marzullo P, et al. Growth hormone and cardiac function. Ann Endocrinol (Paris). 2000;61(1):16-21.
16. Feinberg MS, Scheinowitz M, Laron Z. Echocardiographic dimensions and function in adults with primary growth hormone resistance (Laron syndrome). Am J Cardiol. 2000;85:209-213.
17. Ozbey N, Sezgil A, Oflaz H, et al. Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: Evidence for a subclinical cardiomyopathy. J Endocrinol Invest 2002;25(7):590-597.
18. Bjerregard Sneppen S, Steensgaard-Hansen F, Feldt-Rasmussen U. Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study. Horm Res 2002;58(1):21-29.
19. Link K, Bulow B, Westman K, et al. Low individualized growth hormone (GH) dose increased renal and cardiac growth in young adults with childhood onset GH deficiency. Clin Endocrinol (Oxf) 2001;55(6):741-748.
20. Colao A, di Somma C, Cuocolo A, et al. Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab 2001;86(5):1874-1881.
21. Beshyah SA, Shahi M, Foale R, et al. Cardiovascular effects of prolonged growth hormone replacement in adults. J Intern Med 1995;237(1):35-42.