Low individualized growth hormone (GH) dose increased renal and cardiac growth in young adults with childhood onset GH deficiency

Clinical Endocrinology

Volumn 55, Issue 6, 2001, Pages 741-748

  Link, Katarina ^a   Bülow, Birgitta ^a   Westman, Kerstin ^a   Salmonsson, Eva Cecilia ^a   Eskilsson, Jan ^a   Erfurth, Eva Marie ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; BROMOCRIPTINE; CONJUGATED ESTROGEN; CONTRACEPTIVE AGENT; CORTISONE ACETATE; DESMOPRESSIN; GROWTH HORMONE; IMMUNOGLOBULIN G; IOHEXOL; LEVOTHYROXINE; MEDROXYPROGESTERONE ACETATE; SOMATOMEDIN C; STEROID; TESTOSTERONE ENANTATE;

ADULT; ARTICLE; BIOENERGY; BLOOD LEVEL; BODY COMPOSITION; CHILDHOOD; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DOPPLER ECHOCARDIOGRAPHY; DOSE RESPONSE; DRUG CLEARANCE; FEMALE; GLOMERULUS FILTRATION RATE; GROWTH HORMONE DEFICIENCY; HEART DEVELOPMENT; HEART LEFT VENTRICLE MASS; HUMAN; INDIVIDUALITY; KIDNEY DEVELOPMENT; KIDNEY SIZE; MALE; MEDICAL EXAMINATION; MORPHOLOGY; ONSET AGE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; ULTRASOUND; URINALYSIS;

ADOLESCENT; ADULT; AGE OF ONSET; BODY COMPOSITION; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; GLOMERULAR FILTRATION RATE; GROWTH DISORDERS; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KIDNEY; MALE; PROTEINURIA; RECOMBINANT PROTEINS; THYROID HORMONES;

EID: 0035668161     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2001.01413.x     Document Type: Article

References (34)

1. Body composition, bone metabolism, and heart structure and function in growth hormone (GH) deficient adults before and after GH replacement therapy at low doses
2. Adult growth hormone (GH) -deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment
3. A low individualized GH dose in young patients with childhood onset GH deficiency normalized serum IGF-I without significant deterioration in glucose tolerance
4. Hypopituitary females have a high incidence of cardiovascular morbidity and increased prevalence of cardiovascular risk factors
5. Muscle sympathetic nerve activity in patients with acromegaly
6. Cardiovascular and renal effects of growth hormone
7. Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement
8. Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography
9. Monitoring of growth hormone replacement therapy in adults, based on measurements of serum markers
10. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method
11. Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle I-actin of adult cardiomyocytes
12. Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults
13. Cardiovascular function and glucocorticoid replacement in patients with hypopituitarism
14. Extracellular fluid Volume and renal functionin pituitary insufficiency and acromegaly
15. Renal function and kidney size following hypophysectomy in man
16. Cardiovascular effects of short-term growth hormone hypersecretion
17. The effect of insulin-like growth factor-I on adult rat cardiac contractility
18. Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: Linkage to inositol 1,4,5-triphosphate formation
19. Kidney size in children assessed by ultrasonography and urography
20. The role of the GH/IGF-I axis for cardiac function and structure
21. Longterm cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients
22. Individalized dose titration of growth hormone (GH) during GH replacement in hypopituitary adults
23. Beneficial effects of growth hormone treatment in GH-deficient adults
24. Recombinant human growth hormone therapy does not increase microalbuminuria in children with a short stature
25. Regulation of rat GH receptor gene expression
26. Cardiac structural and functional abnomalities in adult patients with growth hormone deficiency
27. Growth hormone and the heart
28. Observer variability in the sonographic measurement of renal length in childhood
29. Adults with childhood-onset growth hormone deficiency: Effects of growth hormone treatment on cardiac structure
30. Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency
31. Intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency
32. The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism
33. Cardiac performance and mass in adults with hypopituitarism: Effects of one year of growth hormone treatment
34. Growth hormone treatment increases kidney size in a woman with growth hormone deficiency, a case report