Specific Changes in the Posttranslational Regulation of Nucleolin in Lymphocytes from Patients Infected with Human Immunodeficiency Virus

Journal of Infectious Diseases

Volumn 188, Issue 10, 2003, Pages 1483-1491

  Galati, Domenico ^a   Paiardini, Mirko ^c,f,g   Cervasi, Barbara ^c,f,g   Albrecht, Helmut ^g   Bocchino, Marialuisa ^b   Costantini, Andrea ^d,f   Montroni, Maria ^d   Magnani, Mauro ^c   Piedimonte, Giuseppe ^e   Silvestri, Guido ^f,g  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f EMORY UNIVERSITY   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; CYCLIN B1; NUCLEOLIN; PROTEIN KINASE; STRUCTURAL PROTEIN; THREONINE;

ARTICLE; CELL CYCLE; CELL ISOLATION; CELL STRUCTURE; CELL SURFACE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTOSIS; MOLECULAR BIOLOGY; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN PROCESSING;

APOPTOSIS; BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CELL CYCLE; CONCANAVALIN A; CYCLIN B; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICROSCOPY, CONFOCAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA-BINDING PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THREONINE;

EID: 10744224602     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/379249     Document Type: Article

References (30)

1. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373:117-22.
2. + T-cell depletion in HIV disease. Nature 2001; 410:974-9.
3. Finkel TH, Tudor-Williams G, Banda NK, et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat Med 1995; 1:129-34.
4. Gougeon ML, Lecoeur H, Dulioust A, et al. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996; 156:3509-20.
5. Muro-Cacho CA, Pantaleo G, Fauci AS. Analysis of apoptosis in lymph nodes of HIV infected persons: intensity of apoptosis correlates with general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 1995; 154:5555-66.
6. Piedimonte G, Corsi D, Paiardini M, et al. Unscheduled cyclin B1 expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients. AIDS 1999; 13:1159-64.
7. Cannavo' G, Paiardini M, Galati D, et al. Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biological link between immune activation, accelerated T-cell turnover, and high level of apoptosis. Blood 2001; 97:1756-64.
8. Paiardini M, Galati D, Cervasi B, et al. Exogenous IL-2 administration corrects the cell cycle perturbation of lymphocytes from HIV-infected individuals. J Virol 2001; 75:10843-55.
9. Srivastava M, Pollard HB. Molecular dissection of nucleolin's role in growth and cell proliferation: new insights. FASEB J 1999; 13:1911-22.
10. Ginisty H, Sicard H, Roger B, Bouvet P. Structure and functions of nucleolin. J Cell Sci 1999; 112:761-72.
11. Derenzini M, Sirri V, Trere D, Ochs RL. The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells. Lab Invest 1995; 73:497-502.
12. Derenzini M. The AgNORs. Micron 2000; 31:117-20.
13. Borer RA, Lehner CF, Eppenberger HM, Nigg EA. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 1989; 56:379-90.
14. Brockstedt E, Rickers A, Kostka S, et al. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line: cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase3. J Biol Chem 1998; 273:28057-64.
15. Kito S, Shimizu K, Okamura H, et al. Cleavage of nucleolin and argyrophilic nucleolar organizer region associated proteins in apoptosis-induced cells. Biochem Biophys Res Commun 2003; 300:950-6.
16. Schwab MS, Dreyer C. Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin. Eur J Cell Biol 1997; 73:287-97.
17. Peter M, Nakagawa J, Doree M, Labbe JC, Nigg EA. Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell 1990; 60:791-801.
18. Warrener F, Petryshyn R. Phosphorylation and proteolytic degradation of nucleolin from 3T3-F442A cells. Biochem Biophys Res Commun 1991; 180:716-23.
19. Aubele M, Biesterfeld S, Derenzini M, et al. Guidelines of AgNOR quantitation. Committee on AgNOR Quantitation within the European Society of Pathology. Zentralbl Pathol 1994; 140:107-8.
20. Chen CM, Chiang SJ, Yeh NH. Increased stability of nucleolin in proliferating cells by inhibition of its self-cleaving activity. J Biol Chem 1991; 266:7754-8.
21. Hazenberg MD, Stuart JW, Otto SA, et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000; 95:249-55.
22. Mohri H, Perelson AS, Tung K, et al. Increased turnover of T lymphocytes in HIV-infection and its reduction by antiretroviral therapy. J Exp Med 2001; 194:1277-87.
23. Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-70.
24. Martin SJ, Reutelingsperger CP, Kuijten GA, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182:1545-56.
25. Douek DC, Picker LJ, Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol 2003; 21:265-304.
26. Silvestri G, Sodora DL, Koup RA, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003; 18:441-52.
27. Hellerstein M, Hanley MB, Cesar D, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med 1999; 5:83-9.
28. + T cell turnover. Science 1996; 274:1543-47.
29. + T cell turnover in HIV-infected patients. Proc Natl Acad Sci USA 2000; 97:13778-83.
30. + T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy. Nat Med 1998; 4:794-801.