Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

Journal of the American Chemical Society

Volumn 125, Issue 50, 2003, Pages 15443-15454

  Nicolaou, K C ^a,b   Li, Yiwei ^a,b   Sugita, Kazuyuki ^a,b   Monenschein, Holger ^a,b   Guntupalli, Prasuna ^a,b   Mitchell, Helen J ^a,b   Fylaktakidou, Konstantina C ^a,b   Vourloumis, Dionisios ^a,b   Giannakakou, Paraskevi ^c   O'Brate, Aurora ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; SYNTHESIS (CHEMICAL); TUMORS;

BIOLOGICAL EVALUATION;

ORGANIC COMPOUNDS;

ANTINEOPLASTIC AGENT; APOPTOLIDIN; APOPTOLIDIN DERIVATIVE; IODINE DERIVATIVE; MACROLIDE; TIN DERIVATIVE; UNCLASSIFIED DRUG; VINYL IODIDE; VINYLSTANNANE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; GLYCOSIDATION; HUMAN; HUMAN CELL; LACTONIZATION; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLYCOSIDES; HUMANS; MACROLIDES; MODELS, MOLECULAR; OVARIAN NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744222793     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja030496v     Document Type: Article

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