Effects of bile acids on hepatocellular signaling and secretion

Yale Journal of Biology and Medicine

Volumn 70, Issue 4, 1997, Pages 341-346

  Beuers, Ulrich ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BILE ACID; CALCIUM; CALCIUM CHANNEL; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; HORSERADISH PEROXIDASE; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C; RYANODINE; TAUROLITHOCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE;

CALCIUM TRANSPORT; CELL MEMBRANE; CONFERENCE PAPER; ENDOPLASMIC RETICULUM; LIVER; MICROFLUOROMETRY; NONHUMAN; SECRETION;

ANIMALS; BILE ACIDS AND SALTS; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; DIGLYCERIDES; ENZYME ACTIVATION; HUMANS; LIVER; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID;

EID: 0031393725     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (40)

1. ++ activity of isolated rat hepatocytes. Hepatol. 8:887-891, 1988.
2. ++ efflux from isolated rat hepatocytes and perfused rat livers. Proc. Soc. Exp. Biol. Med. 191:147-152, 1989.
3. Combettes, L., Dumont, M., Berthon, B., Erlinger S., and Claret, M. Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells. J. Biol. Chem. 263:2299-2303, 1988.
4. ++ release from permeabilized liver cells and liver microsomes. J. Biol. Chem. 264:157-167, 1989.
5. ++ in rat hepatocytes. Eur. J. Biochem. 190:619-623, 1990.
6. ++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. Biochem. Biophys. Res. Commun. 171:1115-1121, 1990.
7. ++ signals in isolated rat hepatocytes. Gastroenterol. 104:604-612, 1993.
8. ++, mechanisms defective in cholestasis. J. Clin. Invest. 92:2984-2993, 1993.
9. Beuers, U., Throckmorton, D.C., Anderson, M.S., Isales, C.M., Thasler, W., Kullak-Ublick, G.A., Sauter, G., Koebe, H.G., Paumgartner, G., and Boyer, J.L. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterol. 110:1553-1563, 1996.
10. ++ and activates phosphorylase a in isolated hepatocytes. Am. J. Physiol. 264:G243-G251, 1993.
11. Bouscarel, B., Gettys, T.W., Fromm, H., and Dubner, H. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am. J. Physiol. 268:G300-G310, 1995.
12. Stravitz, R.T., Rao, Y.P., Vlahcevic, Z.R., Gurley, E.C., Jarvis, W.D., and Hylemon, P.B. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7a-hydroxylase. Am. J. Physiol. 271:G293-G303, 1996.
13. Nathanson, M.H. and Schlosser, S.F. Calcium signaling mechanisms in liver in health and disease. Progr. Liver Dis. 12:1-27, 1997.
14. Exton, J.H. Role of phosphoinositides in the regulation of liver function. Hepatol. 8:152-166, 1988.
15. Kitani, K. Hepatoprotective effect of Ursodeoxycholate in experimental animals. In: Paumgartner, G., Stiehl, A., Barbara, L., and Roda, E., eds. Strategies for the treatment of hepatobiliary diseases. Lancaster., England: Kluwer Academic Publishers., 1990. pp. 43-56.
16. Heuman, D.M., Mills, A.S., McCall, J., Hylemon, P.B., Pandak, W.M., and Vlahcevic, Z.R. Conjugates of Ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: in vivo studies in the rat. Gastroenterol. 100:203-211, 1991.
17. Galle, P.R., Theilmann, L., Raedsch, R., Otto, G., and Stiehl, A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatol. 12:486-491, 1990.
18. Burgoyne, R.D. and Morgan, A. Regulated exocytosis. Biochem. J. 293:305-316, 1993.
19. - exchanger in rat hepatocytes. Proc. Natl. Acad. Sci. USA 91:792-796, 1994.
20. Boyer, J.L. and Soroka, C.J. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterol. 109:1600-1611, 1995.
21. Larkin, J.M. and Palade, G.E. Transcytotic vesicular carriers for polymeric IgA receptors accumulate in rat hepatocytes after total biliary obstruction. J. Cell Sci. 98:205-216, 1991.
22. Barr, V.A. and Hubbard, A.L. Newly synthesized hepatocyte membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat. Gastroenterol. 105:554-571, 1993.
23. ++ on exocytosis in the isolated perfused rat liver. Hepatol. 20:1032-1040, 1994.
24. Corasanti, J.G., Smith, N.D., Gordon, E.R., and Boyer, J.L. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatol. 10:8-13, 1989.
25. Roelofsen, H., Ottenhoff, R., Oude Elferink, R.P.J., and Jansen, P.L.M. Hepatocellular organic-anion transport is regulated by protein kinase C. Biochem. J. 278:637-641, 1991.
26. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614, 1992.
27. Hug, H. and Sarre, T.F. Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291:329-343, 1993.
28. Nakamura, S. and Nishizuka, Y. Lipid mediators and protein kinase C activation for the intracellular signaling network. J. Biochem. 115:1029-1034, 1994.
29. Exton, J.H. Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265:1-4, 1990.
30. Rao, Y.P., Hylemon, P.B., Vlahcevic, Z.R., and Stravitz, R.T. Activation of protein kinase C isoforms by bile acids in vitro [Abstract]. Hepatol. 24:310A, 1996.
31. Poupon, R.E. and Poupon, R. Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children. Pharmacol. Ther. 66:1-15, 1995.
32. Heathcote, E.J., Lindor, K.D., Poupon, R., et al. Combined analysis of French, American and Canadian randomized controlled trials of ursodeoxycholic acid therapy in primary biliary cirrhosis. Gastroenterol. 108:A1082, 1995.
33. Lindor, K.D., Therneau, T.M., Jorgensen, R.A., Malinchoc, M., and Dickson, E.R. Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis. Gastroenterol. 110:1515-1518, 1996.
34. Beuers, U., Spengler, U., Kruis, W., Aydemir, Ü., Wiebecke, B., Weldwein, W., Weinzierl, M., Pape, G.R., Sauerbruch, T., and Paumgartner G. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trial. Hepatol. 16:707-714, 1992.
35. Stiehl, A., Walker, S., Stiehl, S., Rudolph, G., Hofmann, W.J., and Theilmann, L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period. J. Hepatol. 20:57-64, 1994.
36. Lindor, K.D. and the Mayo PSC/UDCA study group. A randomized trial of ursodeoxycholic acid in the treatment of primary sclerosing cholangitis. Gastroenterology 110:A-844, 1996.
37. Colombo, C., Crosignani, A., Assaisso, M., Battezzati, P.M., Podda, M., Giunta, A., Zimmer-Nechemias, L., and Setchell, K.D.R. Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose-response study. Hepatol. 16:924-930, 1992.
38. Jacquemin, E., Hermans, D., Myara, A., Habes, D., Debray, D., Hadchouel, M., Sokal, E.M., and Bernard, O. Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis. Hepatol. 25:519-523, 1997.
39. Beuers, U., Kullak-Ublick ,G.A., and Paumgartner, G. Mechanisms of action of ursodeoxycholic acid in cholestatic syndromes. In: Strazzabosco, M., Benedetti, A., and Alvaro, D., eds. Vanishing bile duct syndromes. Kluwer Academic., Lancaster., UK., 1997. pp. 230-237.
40. Häussinger, D., Saha, N., Hallbrucker, C., Lang, F., and Gerok, W. Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver. Biochem. J. 291:355-360, 1993.