Glucose metabolism in the antibiotic producing actinomycete Nonomuraea sp. ATCC 39727

Biotechnology and Bioengineering

Volumn 88, Issue 5, 2004, Pages 652-663

  Gunnarsson, Nina ^a,b   Bruheim, Per ^a,c   Nielsen, Jens ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b Fluxome Sciences AS   (Denmark)

^c SINTEF MATERIALS AND CHEMISTRY   (Norway)

Author keywords

13C labeling; Flux analysis; Glycopeptide antibiotics; Nonomuraea

Indexed keywords

ANTIBIOTICS; CARBON; CELLS; ENZYMES; GLUCOSE; METABOLISM; METABOLITES;

DALBAVANCIN; ENTNER-DOUDOROFF (ED) PATHWAY; EUKARYOTES; GLYCOPEPTIDE A40926;

MICROORGANISMS;

6 PHOSPHOFRUCTOKINASE; AMINO ACID; CARBON 13; DALBAVANCIN; GLUCOSE; GLYCOPEPTIDE; PHOSPHATE;

ACTINOBACTERIA; ANAEROBIC METABOLISM; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CARBON METABOLISM; EUKARYOTE; GAS CHROMATOGRAPHY; GENE EXPRESSION; GLUCOSE METABOLISM; GLYCOLYSIS; MASS SPECTROMETRY; NONHUMAN; NONOMURAEA;

ACTINOBACTERIA; ALGORITHMS; ANTI-BACTERIAL AGENTS; CELL PROLIFERATION; COMPUTER SIMULATION; ENERGY METABOLISM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION REGULATION, BACTERIAL; GLUCOSE; GLYCOPEPTIDES; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; SIGNAL TRANSDUCTION; TEICOPLANIN;

ACTINOBACTERIA (CLASS); EMBRYOPHYTA; EUKARYOTA; NONOMURAEA; NONOMURAEA SP. ATCC 39727; UNCULTURED ACTINOMYCETE;

EID: 10644267445     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20279     Document Type: Article

References (44)

1. Alves AMCR, Euverink GJW, Hektor HJ, Hessels GI, van der Vlag J, Vrijbloed JW, Hondmann D, Visser J, Dijkhuizen L. 1994. Enzymes of glucose and methanol metabolism in the actinomycete Amycolatopsis methanolica. J Bacteriol 176:6827-6835.
2. i-dependent phosphofructokinase isoenzymes in the methylotrophic actinomycete Amycolatopsis methanolica. J Bacteriol 183:7231-7240.
3. Bai NJ, Pai MR, Murthy PS, Venkitasubramanian TA. 1976. Pathways of glucose catabolism in Mycobacterium smegmatis. Can J Microbiol 22:1374-1380.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Christensen B, Nielsen J. 1999. Isotopomer analysis using GC-MS. Metab Eng 1:282-290.
6. 13C-labeled glucose. Biotechnol Bioeng 68:652-659.
7. Cocaign-Bousquet M, Guyonvarch A, Lindley ND. 1996. Growth rate-dependent modulation of carbon flux through central metabolism and the kinetic consequences for glucose-limited chemostat cultures of Corynebacterium glutamicum. Appl Environ Microbiol 62:429-436.
8. Conway T. 1992. The Entner-Doudoroff pathway: history, physiology and molecular biology. FEMS Microbiol Rev 103:1-28.
9. Daae EB, Ison AP. (1999) Classification and sensitivity analysis of a proposed primary metabolic network for Streptomyces lividans. Metabol Eng 1:153-165.
10. Dawes EA, Senior PE. 1973. The role and regulation of energy reserve polymers in microorganisms. Adv Microb Physiol 10:135-166.
11. de Jong-Gubbels P, Vanrolleghem P, Heijnen S, van Dijken JP, Pronk JT. 1995. Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol. Yeast 11:407-418.
12. Entner N, Doudoroff M. 1952. Glucose and gluconic acid oxidation of Pseudomonas saccharophila. J Biol Chem 196:853-862.
13. Goldstein BP, Selva E, Gastaldo L, Berti M, Pallanza R, Ripamonti F, Ferrari P, Denaro M, Arioli V, Cassani G. 1987. A40926, a new glycopeptide antibiotic with anti-Neisseria activity. Agents Chemother 31:1961-1966.
14. Gombert AK, dos Santos MM, Christensen B, Nielsen J. 2001. Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol 183:1441-1451.
15. 13C-labeling experiments. Biotechnol Bioeng 2004;86(2):209-216.
16. Gunnarsson N, Bruheim P, Nielsen J. 2003. Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation. J Ind Microbiol Biotechnol 30:150-156.
17. Gunnarsson N, Mortensen UH, Sosio M, Nielsen J. 2004. Identification of the Entner-Doudoroff pathway in an antibiotic producing actinomycete species. Mol Microbiol 2004;52(3):895-902.
18. Hodgson DA. 1982. Glucose repression of carbon source uptake and metabolism in Streptomyces coelicolor A3(2) and its perturbation in mutants resistant to 2-deoxyglucose. J Gen Microbiol 128:2417-2430.
19. Hodgson DA. 2000. Primary metabolism and its control in Streptomycetes: a most unusual group of bacteria. Adv Microb Phys 42:47-238.
20. Hubbard BK, Thomas MG, Walsh CT. 2000. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chem Biol 7:931-942.
21. Ikeda H, Seno ET, Bruton CJ, Chater KF. 1984. Genetic mapping, cloning and physiological aspects of the glucose kinase gene of Streptomyces coelicolor. Mol Gen Genet 196:501-507.
22. Kemp RG, Tripathi RL. 1993. Pyrophosphate-dependent phosphofructo-1- kinase complements fructose 1,6-biphosphatase but not phosphofructokinase deficiency in Escherichia coli. J Bacteriol 175:5723-5724.
23. 2 by the acetyl-CoA pathway. J Gen Microbiol 139:1861-1868.
24. Lee WNP, Byerley LO, Bergner EA, Edmond J. 1991. Mass isotopomer analysis: theoretical and practical considerations. Biol Mass Spectrom 20:451-458.
25. Lee WNP, Bergner EA, Guo ZK. 1992. Mass isotopomer pattern and precursor-product relationship. Biol Mass Spectrom 21:114-122.
26. Li TS, Choroba OW, Hong H, Williams DH, Spencer JB. 2001. Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine. Chem Commun 20:2156-2157.
27. Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H. 1996. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol Bioeng 49:111-129.
28. McMaster GK, Carmichael GG. 1977. Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc Natl Acad Sci USA 74:4835-4838.
29. Meléndez-Hevia E, Waddell TG, Heinrich R, Montero F. 1997. Theoretical approaches to the evolutionary optimization of glycolysis-chemical analysis. Eur J Biochem 244:527-543.
30. Mertens E. 1991. Pyrophosphate-dependent phosphofructokinase, an anaerobic glycolytic enzyme? FEBS Lett 285:1-5.
31. Neidhardt FC, Ingraham JL, Schaechter M. 1990. Physiology of the bacterial cell: a molecular approach. Sunderland, MA: Sinauer Associates. p 136-142.
32. Novotna J, Hostalek Z. 1985. Phosphorylation of hexoses in streptomyces aureofaciens: evidence that the phosphoenolpyruvate: sugar phosphotransferase system is not operative. Fems Microbiol Lett 28:347-350.
33. O'Brien WE, Bowien S, Wood HG. 1975. Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermani. J Biol Chem 250:8690-8695.
34. Petersen S, de Graaf AA, Eggeling L, Mollney M, Wiechert W, Sahm H. 2000. In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum. J Biol Chem 275:35932-35941.
35. Pfeifer V, Nicholson GJ, Ries J, Recktenwald J, Schefers AB, Shawky R, Schröder J, Wohlleben W, Pelzer S. 2001. A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. J Biol Chem 276:38370-38377.
36. Postma E, Verduyn C, Scheffers WA, Van Dijken JP. 1989. Enzymic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl Environ Microbiol 55:468-477.
37. Romano AH, Conway T. 1996. Evolution of carbohydrate metabolic pathways. Res Microbiol 147:448-455.
38. Rossa CA, White J, Kuiper A, Postma PW, Bibb M, Teixeira de Mattos MJ. 2002. Carbon flux distribution in antibiotic-producing chemostat cultures of Streptomyces lividans. Metab Eng 4:138-150.
39. Sabater B, Sebastian J, Asensio C. 1972. Identification and properties of an inducible mannokinase from Streptomyces violaceoruber. Biochim Biophys Acta 284:414-420.
40. Sambrook J, Russell DW. 2001. Molecular cloning: a laboratory manual, 3rd edition. Plainview, NY: Cold Spring Harbor Laboratory Press. 7.42-7.43.
41. Scopes RK, Griffiths-Smith K. 1984. Use of differential dye-ligand chromatography with affinity elution for enzyme purification: 6-phosphogluconate dehydratase from Zymomonas mobilis. Anal Biochem 136:530-534.
42. Steiert M, Schmitz FJ. 2002. Dalbavancin (Biosearch Italia/Versicor). Curr Opin Investig Drugs 3:229-233.
43. Takahashi N, Kalfas S, Yamada T. 1995. Phosphorylating enzymes involved in glucose fermentation of Actinomyces naeslundii. J Bacteriol 177:5806-5811.
44. Zerilli LF, Edwards DM, Borghi A, Gallo GG, Selva E, Denaro M, Lancini GC. 1992. Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strain. Rapid Commun Mass Spectrom 6:109-114.