A novel approach for the detection of potentially hazardous pepsin stable hazelnut proteins as contaminants in chocolate-based food

Journal of Agricultural and Food Chemistry

Volumn 52, Issue 25, 2004, Pages 7726-7731

  Akkerdaas, Jaap H ^a   Wensing, Marjolein ^b   Knulst, André C ^b   Stephan, Oliver ^c   Hefle, Susan L ^d   Aalberse, Rob C ^a   Van Ree, Ronald ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c PAUL EHRLICH INSTITUT   (Germany)

^d UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Allergens; ELISA; Food matrix; Hazelnut; Pepsin digestion

Indexed keywords

ALLERGEN; PEPSIN A; RABBIT ANTISERUM; VEGETABLE PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CACAO; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOD ALLERGY; FOOD CONTAMINATION; HAZELNUT; NONHUMAN; RABBIT;

CACAO; CORYLUS; DRUG STABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOOD CONTAMINATION; PEPSIN A; PLANT PROTEINS;

ANIMALIA; ARACHIS HYPOGAEA; CORYLUS; ORYCTOLAGUS CUNICULUS; THEOBROMA CACAO;

EID: 10644227671     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf049278r     Document Type: Article

References (41)

1. Sampson, H. A.; Metcalfe, D. D. Food allergies. J. Am. Med. Assoc. 1992, 268, 2840-2844.
2. Kagan, R. S. Food allergy: An overview. Environ. Health Perspect. 2003, 111, 223-226.
3. Tariq, S. M.; Stevens, M.; Matthews, S.; Ridout, S.; Twiselton, R.; Hide, D. W. Cohort study of peanut and tree nut sensitisation by age of 4 years. BMJ 1996, 313, 514-517.
4. Emmett, S. E.; Angus, F. J.; Fry, J. S.; Lee, P. N. Perceived prevalence of peanut allergy in Great Britain and its association with other atopic conditions and with peanut allergy in other household members. Allergy 1999, 54, 380-385.
5. Sicherer, S. H.; Munoz-Furlong, A.; Burks, A. W.; Sampson, H. A. Prevalence of peanut and tree nut allergy in the U.S. determined by a random digit dial telephone survey. J. Allergy Clin. Immunol. 1999, 103, 559-562.
6. Breiteneder, H.; Hassfeld, W.; Pettenburger, K.; Jarolim, E.; Breitenbach, M.; Rumpold, H.; Kraft, D.; Scheiner, O. Isolation and characterization of messenger RNA from male inflorescences and pollen of the white birch (Betula verrucosa). Int. Arch. Allergy Appl. Immunol. 1988, 87, 19-24.
7. Hirschwehr, R.; Valenta, R.; Ebner, C.; Ferreira, F.; Sperr, W. R.; Valent, P.; Rohac, M.; Rumpold, H.; Scheiner, O.; Kraft, D. Identification of common allergenic structures in hazel pollen and hazelnuts: A possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. J. Allergy Clin. Immunol. 1992, 90, 927-936.
8. Luttkopf, D.; Schocker, F.; Scheurer, S.; Haustein, D.; Vieths, S. Characterization of minor allergen hazelnut profilin. 2000. EMBL/Genbank/DDBJ/ databases.
9. van Ree, R. The oral allergy syndrome. In Contact Urticaria Syndrome; Amin, S., Lahti, A., Maibach, H. I., Eds.; CRC Press: Boca Raton, 1997.
10. Nordlee, J. A.; Taylor, S. L.; Townsend, J. A.; Thomas, L. A.; Bush, R. K. Identification of a Brazil-nut allergen in transgenic soybeans. N. Engl. J. Med. 1996, 334, 688-692.
11. Pastorello, E. A.; Farioli, L.; Pravettoni, V.; Ispano, M.; Conti, A.; Ansaloni, R.; Rotondo, F.; Incorvaia, C.; Bengtsson, A.; Rivolta, F.; Trambaioli, C.; Previdi, M.; Ortolani, C. Sensitization to the major allergen of Brazil nut is correlated with the clinical expression of allergy. J. Allergy Clin. Immunol. 1998, 102, 1021-1027.
12. Koppelman, S. J.; Bruijnzeel-Koomen, C. A.; Hessing, M.; de Jongh, H. H. Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic properties. J. Biol. Chem. 1999, 274, 4770-4777.
13. Lauer, I.; Mueller, U.; Westphal, S.; Haustein, D.; Vieths, S.; Scheurer, S. Characterisation and cloning of a 48 kDa glycoprotein, from hazelnut (Corylus avellana) as minor allergen. J. Allergy Clin. Immunol. 2002, 109 (1), 302.
14. Pastorello, E. A.; Farioli, L.; Pravettoni, V.; Ortolani, C.; Ispano, M.; Monza, M.; Baroglio, C.; Scibola, E.; Ansaloni, R.; Incorvaia, C.; Conti, A. The major allergen of peach (Prunus persica) is a lipid transfer protein. J. Allergy Clin. Immunol. 1999, 103, 520-526.
15. Sanchez-Monge, R.; Lombardero, M.; Garcia-Selles, F. J.; Barber, D.; Salcedo, G. Lipid-transfer proteins are relevant allergens in fruit allergy. J. Allergy Clin. Immunol. 1999, 103, 514-519.
16. Schocker, F.; Luttkopf, D.; Scheurer, S.; Petersen, A.; Cistero-Bahima, A.; Enrique, E.; Miguel-Moncin, M.; Akkerdaas, J.; van Ree, R.; Vieths, S.; Becker, W. M. Recombinant lipid transfer protein Cor a 8 from hazelnut: A new tool for in vitro diagnosis of potentially severe hazelnut allergy. J. Allergy Clin. Immunol. 2004, 113, 141-147.
17. Asero, R. Detection and clinical characterization of patients with oral allergy syndrome caused by stable allergens in Rosaceae and nuts. Ann. Allergy Asthma Immunol. 1999, 83, 377-383.
18. Krebitz, M.; Peterbauer, C.; Ferreira, F.; Essl, D.; Steinkellner, H.; Scheiner, O.; Breiteneder, H. Production of Mal d 2, a major allergen from apple (Malus domestica), in a plant based expression system, and its biological activity against pathogens. J. Allergy Clin. Immunol. 2001, 2, 188.
19. Sicherer, S. H.; Burks, A. W.; Sampson, H. A. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics 1998, 102, e6.
20. Hourihane, J. O. B.; Kilburn, S. A.; Nordlee, J. A.; Hefle, S. L.; Taylor, S. L.; Warner, J. O. An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: A randomized, double-blind, placebo-controlled food challenge study. J. Allergy Clin. Immunol. 1997, 100, 596-600.
21. Wensing, M.; Penninks, A. H.; Hefle, S. L.; Akkerdaas, J.; van Ree, R.; Koppelman, S.; Bruijnzeel-Koomen, C.; Knulst, A. C. The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind placebo-controlled food challenges (DBPCFCs). Clin. Exp. Allergy 2002, 32, 1757-1762.
22. Wensing, M.; Penninks, A. H.; Hefle, S. L.; Koppelman, S. J.; Bruijnzeel-Koomen, C. A.; Knulst, A. C. The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy. J. Allergy Clin. Immunol. 2002, 110, 915-920.
23. Morisset, M.; Moneret-Vautrin, D. A.; Kanny, G.; Guenard, L.; Beaudouin, E.; Flabbee, J.; Hatahet, R. Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: Evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin. Exp. Allergy 2003, 33, 1046-1051.
24. Mofidi, S.; Bardina, L.; Chatchatee, P.; Wood, R. A.; Sampson, H. A. Reactions to food products labeled dairy-free: Quantity of milk contaminant. J. Allergy Clin. Immunol. 2000, 105 (2), 417.
25. Taylor, S. L.; Nordlee, J. A. Methods for the detection of food allergens. Food Technol. 1996, 50, 231-238.
26. Directive 2000/13/EC of The European Parliament and of the Council of 20 March 2000. Off. J. Eur. Communities 2000, L 109, 29-42.
27. Wigotzki, M.; Steinhart, H.; Paschke, A. Determination of the allergenicity of various hazelnut products by immunoblotting and enzyme allergosorbent test inhibition. J. Chromatogr. B: Biomed. Sci. Appl. 2001, 756, 239-248.
28. Scheibe, B.; Weiss, W.; Rueff, F.; Przybilla, B.; Gorg, A. Detection of trace amounts of hidden allergens: Hazelnut and almond proteins in chocolate. J. Chromatogr. B: Biomed. Sci. Appl. 2001, 756, 229-237.
29. Blais, B. W.; Phillippe, L. Detection of hazelnut proteins in foods by enzyme immunoassay using egg yolk antibodies. J. Food Prot. 2001, 64, 895-898.
30. Holzhauser, T.; Vieths, S. Quantitative sandwich ELISA for determination of traces of hazelnut (Corylus avellana) protein in complex food matrixes. J. Agric. Food Chem. 1999, 47, 4209-4218.
31. Holzhauser, T.; Stephan, O.; Vieths, S. Detection of potentially allergenic hazelnut (Corylus avellana) residues in food: A comparative study with DNA PCR-ELISA and protein sandwich-ELISA. J. Agric. Food Chem. 2002, 50, 5808-5815.
32. Akkerdaas, J. H.; van Ree, R.; Aalbers, M.; Stapel, S. O.; Aalberse, R. C. Multiplicity of cross-reactive epitopes on Bet v I as detected with monoclonal antibodies and human IgE. Allergy 1995, 50, 215-220.
33. Bjorksten, F.; Halmepuro, L.; Hannuksela, M.; Lahti, A. Extraction and properties of apple allergens. Allergy 1980, 35, 671-677.
34. Calkhoven, P. G.; Aalbers, M.; Koshte, V. L.; Pos, O.; Oei, H. D.; Aalberse, R. C. Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures. Allergy 1987, 42, 382-390.
35. Gewürze - Nüsse. Wissenschaftliche Tabellen Geigy; CIBA-GEIGY: 1981.
36. Astwood, J. D.; Leach, J. N.; Fuchs, R. L. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 1996, 14, 1269-1273.
37. Steinbuch, M.; Audran, R. The isolation of IgG from mammalian sera with the aid of caprylic acid. Arch. Biochem. Biophys. 1969, 134, 279-284.
38. Vieths, S.; Hoffmann, A.; Holzhauser, T.; Muller, U.; Reindl, J.; Haustein, D. Factors influencing the quality of food extracts for in vitro and in vivo diagnosis. Allergy 1998, 53, 65-71.
39. Akkerdaas, J. H.; Schocker, F.; Alcocer, M. J.; Schilte, P.; Knulst, A. C.; Hefle, S. L.; Ferreira, F.; Aalberse, R. C. Ree detection and immunological characterization of hazelnut 2S albumin. J. Allergy Clin. Immunol. 2003, 111.
40. Asero, R.; Mistrello, G.; Roncarolo, D.; Amato, S.; Caldironi, G.; Barocci, F.; van Ree, R. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: A clinical study. Allergy 2002, 57, 900-906.
41. Wensing, M.; Knulst, A. C.; Piersma, S.; O'Kane, F.; Knol, E. F.; Koppelman, S. J. Patients with anaphylaxis to pea can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h 1). J. Allergy Clin. Immunol. 2003, 111, 420-424.