Study of HLA as a predisposing factor and its possible influence on the outcome of multiple sclerosis in the sanitary district of Calatayud, northern Spain

Neuroepidemiology

Volumn 18, Issue 4, 1999, Pages 203-209

  Pina, Miguel Angel ^a,e   Ara, J R ^c   Lasierra, P ^d   Modrego, P J ^b   Larrad, L ^d  

^a Obispo Polanco Hospital   (Spain)

^b Hospital de Alcañiz Alcañiz   (Spain)

^c HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^d HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^e NONE   (Spain)

Author keywords

HLA antigens; Multiple sclerosis; Spain

Indexed keywords

HLA DQ ANTIGEN; HLA DR ANTIGEN;

ARTICLE; DISEASE PREDISPOSITION; HLA TYPING; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PREVALENCE; RISK ASSESSMENT; SPAIN;

ADULT; DISEASE PROGRESSION; FEMALE; HLA ANTIGENS; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROGNOSIS; SPAIN; VARIATION (GENETICS);

EID: 0032983171     PISSN: 02515350     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026212     Document Type: Article

References (34)

1. Naito S, Namerow N, Mickey MR, Terasaki PI: Multiple sclerosis: Association with HLA-A3. Tissue Antigens 1972;2:1-4.
2. Jersild C, Svejgaard A, Fog T: HLA antigens and multiple sclerosis. Lancet 1972;i:1240-1241.
3. Older AHL, Batchelor JR, Nason Vakarelis B, Compston DAS, McDonald WI: Optic neuritis and multiple sclerosis: Do factor B alleles influence progression of the disease? Lancet 1981;ii:1246-1248.
4. Jersild C, Fog T, Hansen GS, Thomsen M, Svejgaard A, Dupont B: Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet 1973;ii:1221-1225.
5. Opelz G, Terasaki P, Myers L, Ellison G, Ebers G, Zabriskie J, Weiner H, Kempe H, Sibley W: The association of HLA antigens A3, B7 and DW2 with 330 multiple sclerosis patients in the United States. Tissue Antigens 1977;9:54-58.
6. Batchelor JR, Compston A, McDonald WI: The significance of the association between HLA and multiple sclerosis. Br Med Bull 1978;34:279-284.
7. Miller DH, Homabrook RW, Dagger J, Fong R: Ethnic and HLA patterns related to multiple sclerosis in Wellington, New Zealand. J Neurol Neurosurg Psychiatry 1986;49:43-46.
8. Miller DH, Hornabrook RW, Dagger J, Fong R: Class II HLA antigens in multiple sclerosis. J Neurol Neurosurg Psychiatry 1989;52:575-577.
9. Burguera JA, Montoro JA, Coret F, Soler MA, Blasco R, López J: Estudio HLA, A, B y DR en 20 pacientes con esclerosis múltiple. Arch Neurobiol 1988;51:278-281.
10. Clerici N, Hernández M, Fernández M, Rosique J, Alvarez Cermeño J: Multiple sclerosis is associated with HLA-DR2 antigen in Spain. Tissue Antigens 1989;34:309-311.
11. Clerici N, Fernández M: Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain. J Neuroimmunol 1992;41: 245-248.
12. López-Larrea C, Uría DF, Coto E: HLA antigens in multiple sclerosis of northern Spanish population. J Neurol Neurosurg Psychiatry 1989; 52:434-435.
13. Engell T, Raun NE, Thomsen M, Platz P: HLA and heterogeneity of multiple sclerosis. Neurology 1982; 32:1043-1046.
14. Madigand M, Oger JJ, Fauchet R, Sabouraud O, Genetet B: HLA profiles in multiple sclerosis suggest two forms of the disease and the existence of protective haplotypes. J Neurol Sci 1982;53:519-529.
15. Duquette P, Decary F, Pleines J, Bovin D, Lamoureux G, Cosgrove JB, Lapierre Y: Clinical subgroups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression. Can J Neurol Sci 1985;12:106-110.
16. Olerup O, Hillert J: HLA class II-associated genetic susceptibility in multiple sclerosis: A clinical evaluation. Tissue Antigens 1991;38:1-15.
17. Runmarker B, Martinsson T, Wahlstrom J, Andersen O: HLA and prognosis in multiple sclerosis. J Neurol 1994;241:385-390.
18. o 0, Zaragoza, 1993.
19. Pina MA, Ara JR, Modrego PJ, Morales F, Capablo JL: Prevalence of multiple sclerosis in the sanitary district of Calatayud, northern Spain: Is Spain a zone at high risk for this disease? Neuroepidemiology 1998; 17:258-264.
20. Vallés JA: Antropología del Sistema HLA en la Población Aragonesa Actual; tesis doctoral, Universidad de Zaragoza, 1995.
21. Doménech JM: Métodos estadisticos en ciencias de la salud. Barcelona, Universidad autónoma de Barcelona: gráficas Signo, 1990.
22. Alvarez-Cáceres R: Estadística Multivariante y No Paramétrica con SPSS. Aplicación a Ciencias de la Salud. Madrid, Díaz Santos, 1995.
23. Ebers GC, Sadonick AD: The role of genetic factors in multiple sclerosis susceptibility: A critical review. J Neuroimmunol 1994;54:1-98.
24. Miró J: Esclerosis Múltiple en Cantabria; tesis doctoral, Universidad de Cantabria, Santander, 1990.
25. Fernández O: La Esclerosis Múltiple en la Provincia de Málaga; tesis doctoral, Universidad de Málaga, 1990.
26. Fernández D: Esclerosis Múltiple en Asturias; tesis doctoral, Universidad de Oviedo, 1991.
27. Arbizu T: La Esclerosis Múltiple en el Baix Llobregat; tesis doctoral, Universidad de Barcelona, 1993.
28. Hernández MA, Fernández O: Nuevas Perspectivas en el Diagnóstico de la Esclerosis Múltiple. Sociedad Española de Neurología. XLV Reunión Anual de la SEN, Diciembre 1993. Barcelona, Prodisa, 1994.
29. Hauser SL, Fleischnick E, Weiner HL, Marcus D, Awdeh Z, Yunis EJ, Alper CA: Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology 1989;39:275-277.
30. Fernández O: Esclerosis Múltiple. Una aproximación multidisciplinaria. Madrid, Arké, 1994.
31. Hillert J, Olerup O: HLA and MS. Neurology 1993;43:2426-2427.
32. Compston A, Kellar-Wood H, Wood N: Multiple sclerosis. Baillières Clin Neurol 1994;3:353-371.
33. Eoli M, Pandolfo M, Amoroso A, Salmaggi A, Zaffaroni M, Gasparini P, Di Donato S, Milanese C, Zeviani M: Evidence of linkage between susceptibility to multiple sclerosis and HLA class II loci in Italian multiple families. Eur J Hum Genet 1995;3: 303-311.
34. Kelly MA, Jacobs KH, Penny MA, Mijovic CH, Nightingale S, Barnett AH, et al: An investigation of HLA encoded genetic susceptibility to multiple sclerosis in subjects of Asian Indian and Afro-Caribbean ethnic origin. Tissue Antigens 1995; 45:197-202.