A microarray screen for novel candidate genes in coeliac disease pathogenesis

Gut

Volumn 53, Issue 7, 2004, Pages 944-951

  Diosdado, B ^a   Wapenaar, M C ^a   Franke, L ^a   Duran, K J ^a   Goerres, M J ^b   Hadithi, M ^b,c   Crusius, J B A ^c   Meijer, J W R ^b   Duggan, D J ^d,e   Mulder, C J J ^b,c   Holstege, F C P ^a   Wijmenga, C ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^e TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTEN;

ADULT; AGED; ALDOB GENE; ARTICLE; CELIAC DISEASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DUODENUM BIOPSY; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; IL2RB2 GENE; INTESTINE VILLUS ATROPHY; MALE; PATHOGENESIS; PDE7B GENE; PRESCHOOL CHILD; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TM4SF4 GENE; TXN GENE; TYK2 GENE;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CELIAC DISEASE; CHILD, PRESCHOOL; DUODENUM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GLUTEN; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 1042294578     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.018374     Document Type: Article

References (26)

1. Vader W, Kooy Y, Van Veelen P, et al. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002;122:1729-37.
2. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000;18:53-81.
3. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992;102:330-54.
4. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55.
5. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000;119:234-42.
6. Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature 2000;405:827-36.
7. Mulder C, Rostami K, Marsh MN. When is a coeliac a coeliac? Gut 1998;42:594.
8. Mulder CJ, Wahab PJ, Moshaver B, et al. Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma. Scand J Gastroenterol Suppl 2000;232:32-7.
9. Van de Peppel JPK, van Bakel H, Radonjic M, et al. Monitoring global mRNA changes with externally controlled microarray experiments. EMBO 2002;4:387-93.
10. Brazma A, Hingamp P, Quackenbush J, et al. Minimum information about a microarray experiment (MIAME) - toward standards for microarray data. Nat Genet 2001;29:365-71.
11. Chen Y, Kamat V, Dougherty ER, et al. Ratio statistics of gene expression levels and applications to microarray data analysis. Bioinformatics 2002;18:1207-15.
12. Chen Y, Kamat V, Dougherty ER, et al. Ratio statistics of gene expression levels and applications to microarray data analysis. Bioinformatics 2002;18:1207-15.
13. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods Method 2001;25:402-8.
14. Nilsen EM, Jahnsen FL, Lundin KE, et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998;115:551-63.
15. Nicoletti A, Caligiuri G, Tornberg I, et al. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol 1999;29:512-21.
16. Yokota T, Ehlin-Henriksson B, Hansson GK. Scavenger receptors mediate adhesion of activated B lymphocytes. Exp Cell Res 1998;239:16-22.
17. Choudhury A, Mukherjee P, Basu SK, et al. Disruption of T cell tolerance to self-immunoglobulin causes polyclonal B cell stimulation followed by inactivation of responding autoreactive T cells. J Immunol 2000;164:1713-21.
18. Abraham R, Choudhury A, Basu SK, et al. Disruption of T cell tolerance by directing a self antigen to macrophage-specific scavenger receptors. J Immunol 1997;158:4029-35.
19. Angelini G, Gardella S, Ardy M, et al. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci U S A 2002;99:1491-6.
20. Fahrer AM, Konigshofer Y, Kerr EM, et al. Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile. Proc Natl Acad Sci U S A 2001;98:10261-6.
21. Nilsen EM, Lundin KE, Krajci P, et al. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995;37:766-76.
22. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol 2002;283:G996-1003.
23. Shan L, Molberg O, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002;297:2275-9.
24. Wice BM, Gardon JI. A tetraspon membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. J Biol Chem 1995;270:21907-18.
25. Battle E, Henderson JT, Beghtel H, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB. Cell 2002;111:251-63.
26. Salmela MT, MacDonald TT, Black D, et al. Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. Gut 2002;51:540-7.