-
1
-
-
4444259316
-
Old-fashioned genetics remains genomics' best friend. Business briefing
-
Pimstone, S. (2002) Old-fashioned genetics remains genomics' best friend. Business briefing. Pharmatechnology 1, 88-90
-
(2002)
Pharmatechnology
, vol.1
, pp. 88-90
-
-
Pimstone, S.1
-
2
-
-
0036258280
-
Loss-of-function strategies in drug target validation
-
May, 17-21
-
Henning, S.W. and Beste, G. (2002) Loss-of-function strategies in drug target validation. Curr. Drug Discov. May, 17-21
-
(2002)
Curr. Drug Discov.
-
-
Henning, S.W.1
Beste, G.2
-
3
-
-
0036742715
-
Applications of antisense and siRNAs during preclinical development
-
Thompson, J.D. (2002) Applications of antisense and siRNAs during preclinical development. Drug Discov. Today 7, 912-917
-
(2002)
Drug Discov. Today
, vol.7
, pp. 912-917
-
-
Thompson, J.D.1
-
4
-
-
0033022089
-
Application of antisense oligunucleotides for gene functionalization and target validation
-
Bennett, C.F. and Cowsert, L.M. (1999) Application of antisense oligunucleotides for gene functionalization and target validation. Curr. Opin. Mol. Ther. 1, 359-371
-
(1999)
Curr. Opin. Mol. Ther.
, vol.1
, pp. 359-371
-
-
Bennett, C.F.1
Cowsert, L.M.2
-
5
-
-
0031912506
-
Antisense oligunucleotides: Is the glass half full or half empty?
-
Bennett, C.F. (1998) Antisense oligunucleotides: is the glass half full or half empty? Biochem. Pharmacol. 55, 9-19
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 9-19
-
-
Bennett, C.F.1
-
6
-
-
0034853258
-
Discovery and analysis of antisense oligunucleotide activity in cell culture
-
Baker, B.F. et al. (2001) Discovery and analysis of antisense oligunucleotide activity in cell culture. Methods 23, 191-198
-
(2001)
Methods
, vol.23
, pp. 191-198
-
-
Baker, B.F.1
-
7
-
-
0032700356
-
Importance of nucleotide sequence and chemical modification of antisense oligunucleotides
-
Agrawal, S. (1999) Importance of nucleotide sequence and chemical modification of antisense oligunucleotides. Biochim. Biophys. Acta 1489, 53-68
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 53-68
-
-
Agrawal, S.1
-
8
-
-
0034960390
-
Chemistry and biochemistry of 2,5-oligoadenylate-based antisense strategy
-
Adah, S.A. et al. (2001) Chemistry and biochemistry of 2,5-oligoadenylate-based antisense strategy. Curr. Med. Chem. 8, 1189-1212
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1189-1212
-
-
Adah, S.A.1
-
9
-
-
0026341239
-
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
-
Nielsen, P.E. et al. (1991) Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500
-
(1991)
Science
, vol.254
, pp. 1497-1500
-
-
Nielsen, P.E.1
-
10
-
-
0034939942
-
Phosphorodiamidate morpholino oligomers: Favorable properties for sequence-specific gene in activation
-
Iversen, P.I. (2001) Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene in activation. Curr. Opin. Mol. Ther. 3, 235-238
-
(2001)
Curr. Opin. Mol. Ther.
, vol.3
, pp. 235-238
-
-
Iversen, P.I.1
-
11
-
-
0034938693
-
Locked nucleic acids: A promising molecular family for gene-function analysis and antisense drug development
-
Orum, H. and Wengel, J. (2001) Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development. Curr. Opin. Mol. Ther. 3, 239-243
-
(2001)
Curr. Opin. Mol. Ther.
, vol.3
, pp. 239-243
-
-
Orum, H.1
Wengel, J.2
-
13
-
-
0001857028
-
Antisense oligodeoxynucleotides - Highly specific tools for basic research and pharmacotherapy
-
Schlingeusiepen, R. and Brysch, W., eds, Blackwell
-
Schlingensiepen, R. and Schlingensiepen, K. W. (1997) Antisense oligodeoxynucleotides - highly specific tools for basic research and pharmacotherapy. In Antisense - From Technology to Therapy (Schlingeusiepen, R. and Brysch, W., eds), pp 3-28, Blackwell
-
(1997)
Antisense - From Technology to Therapy
, pp. 3-28
-
-
Schlingensiepen, R.1
Schlingensiepen, K.W.2
-
14
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
15
-
-
0035281741
-
RNA interference - 2001
-
Sharp, P.A. (2001) RNA interference - 2001. Genes Dev. 15, 485-490
-
(2001)
Genes Dev.
, vol.15
, pp. 485-490
-
-
Sharp, P.A.1
-
16
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir, S.M. et al. (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
-
17
-
-
20444391038
-
Prescription RNA
-
Garber, K. (2003) Prescription RNA. Technol. Rev. 1, 42-48
-
(2003)
Technol. Rev.
, vol.1
, pp. 42-48
-
-
Garber, K.1
-
18
-
-
0036629241
-
Probes for chemical genomics by design
-
Zanders, E.D. et al. (2002) Probes for chemical genomics by design. Drug Discov. Today 7, 711-718
-
(2002)
Drug Discov. Today
, vol.7
, pp. 711-718
-
-
Zanders, E.D.1
-
19
-
-
0034920256
-
Chemical genomics: What will it take and who gets to play?
-
MacBeath, G. (2001) Chemical genomics: what will it take and who gets to play? Genome Biol. 2
-
(2001)
Genome Biol.
, vol.2
-
-
MacBeath, G.1
-
20
-
-
0037114941
-
Aptamers as tools for target prioritization and lead identification
-
Burgstaller, P. et al. (2002) Aptamers as tools for target prioritization and lead identification. Drug Discov. Today 7, 1221-1228
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1221-1228
-
-
Burgstaller, P.1
-
21
-
-
0032486397
-
RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase
-
Bell, S.D. et al. (1998) RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase. J. Biol. Chem. 273, 14309-14314
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14309-14314
-
-
Bell, S.D.1
-
22
-
-
0344213748
-
Chemically modified nucleic acid aptamers for in vitro selections: Evolving evolution
-
Kusser, W. (2000) Chemically modified nucleic acid aptamers for in vitro selections: evolving evolution. J. Biotechnol. 74, 27-38
-
(2000)
J. Biotechnol.
, vol.74
, pp. 27-38
-
-
Kusser, W.1
-
23
-
-
0036009326
-
GnRH binding RNA and DNA spiegelmers. A novel approach toward GnRH antagonism
-
Leva, S. et al. (2002) GnRH binding RNA and DNA spiegelmers. A novel approach toward GnRH antagonism. Chem. Biol. 9, 351-359
-
(2002)
Chem. Biol.
, vol.9
, pp. 351-359
-
-
Leva, S.1
-
24
-
-
0037173068
-
In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class
-
Wlotzka, B. et al. (2002) In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class. Proc. Natl. Acad. Sci. U. S. A. 99, 8898-8902
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 8898-8902
-
-
Wlotzka, B.1
|