Towards developing HIV-2 lentivirus-based retroviral vectors for gene therapy: Dual gene expression in the context of HIV-2 LTR and Tat

Journal of Medical Virology

Volumn 54, Issue 2, 1998, Pages 118-128

  Sadaie, M Reza ^a   Zamani, Maryam ^b   Whang, Suk ^b   Sistron, Nicki ^b   Arya, Suresh K ^b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

AIDS; Gene transfer; Promoter cell specificity; Regulatory loops

Indexed keywords

TRANSACTIVATOR PROTEIN; VIRUS VECTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; LENTIVIRINAE; LONG TERMINAL REPEAT; LYMPHOCYTE; MOLECULAR CLONING; RETROVIRUS; TRANSLATION INITIATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CHLORAMPHENICOL O-ACETYLTRANSFERASE; GENE PRODUCTS, TAT; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; HIV LONG TERMINAL REPEAT; HIV-2; HUMANS; TRANSFECTION;

EID: 1042282180     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199802)54:2<118::AID-JMV9>3.0.CO;2-9     Document Type: Article

References (38)

1. Akkina RK, Walton RM, Chen ML, Li QX, Planelles V, Chen, ISY (1996): High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein. Journal of General Virology 70:2581-2585.
2. Anderson WF (1992): Human gene therapy. Science 256:808-813.
3. Arya SK (1987): 3′-orf and sor genes of human immunodeficiency virus: In vitro transcription-translation and immunoreactive domains. Proceedings of the National Academy of Sciences USA 84: 5429-5433.
4. Arya SK, Gallo RC (1988): Human immunodeficiency virus type 2 long terminal repeat: Analysis of regulatory elements. Proceedings of the National Academy of Sciences USA 85:9753-9757.
5. Arya SK (1990): Human immunodeficiency virus type-2 gene expression: Two enhancers and their activation by T-cell activators. New Biologist 2:57-65.
6. Arya SK (1993): Human immunodeficiency virus type 2 (HIV-2) transactivator (Tat): Functional domains and the search for transdominant negative mutants. AIDS Research and Human Retroviruses 9:839-848.
7. Arya SK, Sadaie MR (1993): Fusogenicity of mutant and chimeric proviruses derived from molecular clones of cytopathic and non-cytopathic human immunodeficiency virus type 2. Journal of Acquired Immune Deficiency Syndromes 6:1205-1211.
8. Arya SK, Mohr JR (1994): Conditional regulatory elements of human immunodeficiency virus type 2 long terminal repeat. Journal of General Virology 75:2253-2260.
9. Arya SK, Zamani M, Gallo RC (1994): HIV-2 inhibits HIV-1. AIDS Research and Human Retroviruses 10:S158.
10. Arya SK, Gallo RC (1996a): Advances in genetics: Gene therapy. In Lanza R (ed): "One World: The Health and Survival of the Human Species in the 21st Century." New Mexico: Health Press, pp 49-57.
11. Arya SK, Gallo RC (1996b): Human immunodeficiency virus (HIV) type-2 mediated inhibition of HIV type 1: A new approach to gene therapy of HIV infection. Proceedings of the National Academy of Sciences USA 93:4486-4491.
12. Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV, Rafadi Y, Ciccarelli RB, McCallus D, Coney L, Weiner DB (1997): Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature Medicine 3:526-532.
13. Bowtell DD, Cory S, Johnson GR, Gonda TJ (1988): Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes. Journal of Virology 62:2464-2473.
14. Chen BF, Hwang LH, Chen DS (1993): Characterization of a bicistronic retroviral vector composed of the swine vesicular disease virus internal ribosome entry site. Journal of Virology 67:2142-2148.
15. Corbeau P, Kraus G, Wong-Staal F (1996): Efficient gene transfer by a human immunodeficiency virus type I (HIV-I)-derived vector utilizing a stable HIV packaging cell line. Proceedings of the National Academy of Sciences USA 93:14070-14075.
16. Correll PH, Colilla S, Karlsson S (1994): Retroviral vector design for long-term expression in murine hematopoietic cells in vivo. Blood 84:1812-1822.
17. Crystal RB (1995): Transfer of genes to humans: Early lessons and obstacles to success. Science 270:404-410.
18. Duan L, Zhang H, Oakes JW, Bagasra O, Pomerantz RJ (1997): DNA and amino acid sequence of anti-HIV-1 Rev sFV. Human Gene Therapy 8:510-516.
19. Fletcher TM, Brichacek B, Sharova N, Newman MA, Stivahtis G, Sharp PM, Emerman M, Hahn BH, Stevenson M (1996): Nuclear import and cell cycle arrest functions of the HIV-1 vpr protein are encoded by two separate genes in HIV-2/SIVsm. EMBO Journal 15:6155-6165.
20. Garzino-Demo A, Gallo RC, Arya SK (1995): Human immunodeficiency virus type 2 (HIV-2): Packaging signal and associated negative regulatory element. Human Gene Therapy 6:177-184.
21. Gervaix A, Li X, Kraus G, Wong-Staal F (1997): Multigene antiviral vectors inhibit diverse human immunodeficiency virus type 1 clades. Journal of Virology 71:3048-3053.
22. Ghattas IR, Sanes JR, Majors JE (1991): The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Molecular and Cellular Biology 11:5848-5859.
23. Gilboa E, Eglitis MA, Kantoff PW, Anderson WF (1986): Transfer and expression of cloned genes using retroviral vectors. Biotechniques 4:504-512.
24. Kashanchi F, Melpolder JC, Epstein JS, Sadaie MR (1997): Rapid and sensitive detection of cell-associated HIV-1 in latently infected cell lines and in patient cells using sodium-n-butyrate induction and RT-PCR. Journal of Medical Virology 52:179-189.
25. Kozak M (1991): Structural features in eukaryotic mRNAs that modulate the initiation of translation. Journal of Biological Chemistry 266:19867-19870.
26. Kumar P, Hui H, Kappes TC, Haggarty BS, Hoxie JA, Arya SK, Shaw GM, Hahn BH (1990): Molecular characterization of an attenuated human immunodeficiency virus type 2 isolate. Journal of Virology 64:890-901.
27. Laspia MF, Rice AP, Matthews MP (1989): HIV-1 tat protein increases transcriptional initiation and stabilizes elongation. Cell 59:283-292.
28. Li M, Hantzopoulos PA, Banerjee D, Zhao SC, Schweitzer BI, Gilboa E, Bertino JR (1992): Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors. Human Gene Therapy 3:381-390.
29. Markovitz DM, Hannibal M, Perez VL, Guantt C, Folks TM, Nabel GJ (1990): Differential regulation of human immunodeficiency viruses (HIVs): A specific regulatory element in HIV-2 responds to stimulation of the T-cell antigen receptor. Proceedings of the National Academy of Sciences USA 87:9098-9102.
30. Miller AD, Rosman GJ (1989): Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980-982, 984-986, 989-990.
31. Mitchell BS, Dhani D, Schumacher U (1992): In situ hybridization: A review of methodologies and applications in biomedical sciences. Medical Laboratory Sciences. 49:107-118.
32. Morgan RA, Couture L, Elroy-Stein O, Ragheb J, Moss B, Anderson WF (1992): Retroviral vectors containing putative internal ribosome entry sites: Development of a polycistronic gene transfer system and applications to human gene therapy. Nucleic Acids Research 20:1293-1299.
33. Mukhtar M, Duan L, Bagasra O, Pomerantz RJ (1996): Evaluation of relative promoter strengths of the HIV-1-LTR and a chimeric RSV-LTR in T lymphocytic cells and peripheral blood mononuclear cells: Promoters for anti-HIV-1 gene therapies. Gene Therapy 3: 725-730.
34. Mulligan RC (1993): The basic science of gene therapy. Science 260: 926-932.
35. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D (1996): In vivo gene delivery and stable transduction of non-dividing cells by a lentiviral vector. Science 272:263-267.
36. Robinson D, Elliot JF, Chang L-J (1995): Retroviral vector with a CMV-IE/HIV-1 TAR hybrid LTR gives high basal expression levels and is up-regulated by HIV-1 Tat. Gene Therapy 2:269-278.
37. Rosenzweig M, Marks DF, Hempel D, Lisziewicz J, Johnson RP (1997): Transduction of CD34+ hematopoietic progenitor cells with an antistat gene protects T-cell and macrophage progeny from AIDS virus infection. Journal of Virology 71:2740-2746.
38. Woffendin C, Ranga U, Yang Z, Xu L, Nabel GJ (1996): Expression of a protective gene prolongs survival of T-cells in human immunodeficiency virus-infected patients. Proceedings of the National Academy of Sciences USA 93:2889-2894.