High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma

Human Pathology

Volumn 35, Issue 11, 2004, Pages 1324-1331

  Chan, Kok Lung ^a   Guan, Xin Yuan ^a   Ng, Irene Oi Lin ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

c myc amplification; FISH; fluorescence in situ hybridization; HbsAG; HCC; hepatitis B surface antigen; hepatocellular carcinoma; immunohistochemistry

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CYTOPLASM; DNA MICROARRAY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; GENE LOCATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; ONCOGENE; ONCOGENE C MYC;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER NEOPLASMS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR MARKERS, BIOLOGICAL;

EID: 10044285749     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2004.06.012     Document Type: Article

References (31)

1. Marchio A., Meddeb M., Pineau P., et al. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer. 18:1997;59-65
2. Marchio A., Pineau P., Meddeb M., et al. Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene. 19:2000;3733-3738
3. Collonge-Rame M.A., Bresson-Hadni S., Koch S., et al. Pattern of chromosomal imbalances in non-B virus-related hepatocellular carcinoma detected by comparative genomic hybridization. Cancer Genet Cytogenet. 127:2001;49-52
4. Kusano N., Shiraishi K., Kubo K., et al. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas Their relationship to clinicopathological features. Hepatology. 29:1999;1858-1862
5. Parada L.A., Hallen M., Tranberg K.G., et al. Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer. Genes Chromosomes Cancer. 23:1998;26-35
6. Wong N., Lai P., Lee S.W., et al. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis Relationship to disease stage, tumor size, and cirrhosis. Am J Pathol. 154:1999;37-43
7. Guan X.Y., Fang Y., Sham J.S., et al. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer. 29:2000;110-116
8. Wang G., Zhao Y., Liu X., et al. Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes Cancer. 31:2001;221-227
9. Sakakura C., Hagiwara A., Taniguchi H., et al. Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization. Br J Cancer. 80:1999;2034-2039
10. Zimonjic D.B., Keck C.L., Thorgeirsson S.S., et al. Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology. 29:1999;1208-1214
11. Rochlitz C.F., Herrmann R., de Kant E. Overexpression and amplification of c-myc during progression of human colorectal cancer. Oncology. 53:1996;448-454
12. Bruckert P., Kappler R., Scherthan H., et al. Double minutes and c-myc amplification in acute myelogenous leukemia Are they prognostic factors? Cancer Genet Cytogenet. 120:2000;73-79
13. Jenkins R.B., Qian J., Lieber M.M., et al. Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Res. 57:1997;524-531
14. Scorilas A., Trangas T., Yotis J., et al. Determination of c-myc amplification and overexpression in breast cancer patients Evaluation of its prognostic value against c-erbB-2, cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis. Br J Cancer. 81:1999;1385-1391
15. Kononen J., Bubendorf L., Kallioniemi A., et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 4:1998;844-847
16. Ng I.O., Lai E.C., Fan S.T., et al. Prognostic significance of pathologic features of hepatocellular carcinoma A multivariate analysis of 278 patients. Cancer. 76:1995;2443-2448
17. Yin X.Y., Grove L., Datta N.S., et al. c-myc overexpression and p53 loss cooperate to promote genomic instability. Oncogene. 18:1999;1177-1184
18. Vafa O., Wade M., Kern S., et al. c-myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function A mechanism for oncogene-induced genetic instability. Mol Cell. 9:2002;1031-1044
19. Donato M.F., Arosio E., Del Ninno E., et al. High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity. Hepatology. 34:2001;523-528
20. Kaita K.D., Pettigrew N., Minuk G.Y. Hepatic regeneration in humans with various liver disease as assessed by Ki-67 staining of formalin-fixed, paraffin-embedded liver tissue. Liver. 17:1997;13-16
21. Kawate S., Fukusato T., Ohwada S., et al. Amplification of c-myc in hepatocellular carcinoma Correlation with clinicopathologic features, proliferative activity and p53 overexpression. Oncology. 57:1999;157-163
22. Abou-Elella A., Gramlich T., Fritsch C., et al. c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis. Mod Pathol. 9:1996;95-98
23. Yuen M.F., Wu P.C., Lai V.C., et al. Expression of c-myc c-fos, and c-jun in hepatocellular carcinoma. Cancer. 91:2001;106-112
24. Himeno Y., Fukuda Y., Hatanaka M., et al. Expression of oncogenes in human liver disease. Liver. 8:1988;208-212
25. Su T.S., Lin L.H., Lui W.Y., et al. Expression of c-myc gene in human hepatoma. Biochem Biophys Res Commun. 132:1985;264-268
26. Walker R.A., Senior P.V., Jones J.L., et al. An immunohistochemical and in situ hybridization study of c-myc and c-erbB-2 expression in primary human breast carcinomas. J Pathol. 158:1989;97-105
27. Schleger C., Verbeke C., Hildenbrand R., et al. c-myc activation in primary and metastatic ductal adenocarcinoma of the pancreas Incidence, mechanisms, and clinical significance. Mod Pathol. 15:2002;462-469
28. Felsher D.W., Bishop J.M. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A. 96:1999;3940-3944
29. Ng I.O., Lai E.C., Ng M., et al. Tumor encapsulation in hepatocellular carcinoma A pathologic study of 189 cases. Cancer. 70:1992;45-49
30. Donzelli M., Bernardi R., Negri C. Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene. Oncogene. 18:1999;439-448
31. Shim H., Chun Y.S., Lewis B.C., et al. A unique glucose-dependent apoptotic pathway induced by c-myc. Proc Natl Acad Sci U S A. 95:1998;1511-1516