Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 3, 2004, Pages 1138-1146

  Schaddelee, M P ^a,b   Groenendaal, D ^a   DeJongh, J ^a   Cleypool, C G J ^a   Ijzerman, A P ^a   De Boer, A G ^a   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLORO 2 METHYLPHENOXY)ACETIC ACID; 2' DEOXYRIBOSE N6 CYCLOPENTYLADENOSINE; 6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TRANSPORT; EXTRACELLULAR FLUID; MALE; MICRODIALYSIS; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ADENOSINE; ALGORITHMS; ANIMALS; BAYES THEOREM; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; DEOXYADENOSINES; HUMANS; INJECTIONS, INTRAVENOUS; LINEAR MODELS; MALE; MICRODIALYSIS; MODELS, BIOLOGICAL; POPULATION; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1;

EID: 10044280369     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.071308     Document Type: Article

References (27)

1. Akaike H (1974) A new look at the statistical model identification. IEEE Trans Automat Control AC-19:716-723.
2. Bourne JA (2003) Intracerebral microdialysis: 30 years as a tool for the neuroscientist. Clin Exp Pharmacol Physiol 30:16-24.
3. Bouw MR, Xie R, Tunblad K, and Hammarlund-Udenaes M (2001) Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats: pharmacokinetic-pharmacodynamic modelling. Br J Pharmacol 134:1796-1804.
4. Bungay PM, Morrison PF, and Dedrick RL (1990) Steady state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci 46:105-119.
5. De Lange ECM, Danhof M, De Boer AG, and Breimer DD (1997) Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res Rev 25:27-49.
6. De Lange ECM, De Boer AG, and Breimer DD (1999) Mircodialysis for for pharmacokinetic analysis of drug transport to the brain. Adv Drug Del Rev 36:211-227.
7. De Visscher G, Haseldonckx M, Flameng W, Borgers M, Reneman RS, and Van Rossem K (2003) Development of a novel fluorescent microsphere technique to combine serial cerebral blood flow measurements with histology in the rat. J Neurosci Methods 122:149-156.
8. Elmquist WF and Sawchuk RJ (1997) Application of microdialysis in pharmacokinetic studies. Pharm Res 14:267-288.
9. Gaillard PJ, Voorwinden LH, Nielsen J, Ivanov A, Atsumi R, Engman H, Ringbom C, De Boer AG, and Breimer DD (2001) Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eur J Pharm Sci 12:215-222.
10. Hammarlund-Udenaes M (2000) The use of microdialysis in CNS drug delivery studies: pharmacokinetic perspectives and results with analgesics and antiepileptics. Adv Drug Dev Rev 45:293-294.
11. Levy RH and Moreland TA (1984) Rationale for monitoring free drug levels. Clin Pharmacokinet 9:1-9.
12. Madara JL (1998) Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 60:143-159.
13. Malhotra BK, Lemaire M, and Sawchuk RJ (1994) Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilising microdialysis. Pharm Res 11:1223-1232.
14. Malhotra J and Gupta YK (1997) Effect of adenosine receptor modulation on pentylenetetrazole-induced seizure rats. Br J Pharmacol 120:282-288.
15. 1 receptor in vivo. Br J Pharmacol 116:1957-1964.
16. Moghaddam B and Bunney BS (1989) Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J Neurochem 53:652-654.
17. Morrison PF, Bungay PM, Hsiao JK, Mefford IV, Dijkstra KH, and Dedrick RL (1992) Quantitative microdialysis, in Microdialysis in Neuroscience, Elsevier Science B.V., Amsterdam.
18. Olson J and Justice JB Jr (1993) Quantitative microdialysis under transient conditions. Anal Chem 65:1017-1022.
19. Pardridge WM (1991) Peptide Drug Delivery into the Brain. Raven Press, New York.
20. Rubin LL, Hall DE, Parter S, Barbu K, Cannon C, Horner HC, Janatpour M, Liaw CW, Manning K, Morales J, et al. (1991) A cell culture model of the blood-brain barrier. J Cell Biol 115:1725-1735.
21. Sawynok J (1998) Adenosine receptor activation and nociception. Eur J Pharmacol 317:1-11.
22. 1 receptor agonists: structure-in vitro transport relationships. Eur J Pharm Sci 20:347-356.
23. Schoemaker RC and Cohen AF (1996) Estimating impossible curves using NON-MEM. Br J Pharmacol 42:283-290.
24. Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, and McCarley RW (2000) Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav Brain Res 115:183-204.
25. Van Schaick EA, Mathôt RAA, Gubbens-Stibbe JM, Langemeijer MWE, Roelen HCPF, IJzerman AP, and Danhof M (1997) 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine Al receptors in vivo. J Pharmacol Exp Ther 283:800-809.
26. von Lubitz DK (1999) Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? Eur J Pharmacol 371:85-102.
27. von Lubitz DK (2001) Adenosine in the treatment of stroke: yes, maybe, or absolutely not? Expert Opin Investig Drugs 10:619-632.