Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies

Journal of Leukocyte Biology

Volumn 76, Issue 6, 2004, Pages 1162-1170

  Van Rossum, André P ^a   Rarok, Agnieszka A ^a   Huitema, Minke G ^a   Fassina, Giorgio ^b   Limburg, Pieter C ^a   Kallenberg, Cees G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Xeptagen   (Italy)

Author keywords

ANCA; PMN; Vasculitis; WG

Indexed keywords

DIHYDRORHODAMINE; MONOCLONAL ANTIBODY; MYELOBLASTIN; MYELOBLASTIN ANTIBODY; PROTEIN ANTIBODY; RHODAMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELAPSE; RESPIRATORY BURST; WEGENER GRANULOMATOSIS;

ACTINS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; CELL MEMBRANE; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MYELOBLASTIN; NEUTROPHILS; REACTION TIME; RECURRENCE; RESPIRATORY BURST; SERINE ENDOPEPTIDASES; TUMOR NECROSIS FACTOR-ALPHA; WEGENER GRANULOMATOSIS;

EID: 10044246281     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0604319     Document Type: Article

References (44)

1. van der Woude, F. J., Rasmussen, N., Lobatto, S., Wiik, A., Permin, H., van Es, L. A., van der Giessen, M., van der Hem, G. K., The T. H. (1985) Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1, 425-429.
2. Niles, J. L., McCluskey, R. T., Ahmad, M. F., Arnaout, M. A. (1989) Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood 74, 1888-1893.
3. Lüdemann, J., Utecht, B., Gross, W. L. (1990) Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. J. Exp. Med. 171, 357-362.
4. Boomsma, M. M., Stegeman, C. A., van der Leij, M. J., Oost, W., Hermans, J., Kallenberg, C. G., Limburg, P. C., Tervaert, J. W. (2000) Prediction of relapses in Wegener's granulomatosis by measurement of anti-neutrophil cytoplasmic antibody levels: a prospective study. Arthritis Rheum. 43, 2025-2033.
5. Dewald, B., Rindler-Ludwig, R., Bretz, U., Baggiolini, M. (1975) Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes. J. Exp. Med. 141, 709-723.
6. Gabay, J. E., Heiple, J. M., Cohn, Z. A., Nathan, C. F. (1986) Subcellular location and properties of bactericidal factors from human neutrophils. J. Exp. Med. 164, 1407-1421.
7. Witko-Sarsat, V., Cramer, E. M., Hieblot, C., Guichard, J., Nusbaum, P., Lopez, S., Lesavre, P., Halbwachs-Mecarelli, L. (1999) Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophilic granules. Blood 94, 2487-2496.
8. Halbwachs-Mecarelli, L., Bessou, G., Lesavre, P., Lopez, S., Wilko-Sarsat, V. (1995) Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool. FEBS Lett. 374, 29-33.
9. Witko-Sarsat, V., Lesavre, P., Lopez, S., Bessou, G., Hieblot, C., Prum, B., Noel, L. H., Guillevin, L., Ravaud, P., Sermet-Gaudelus, I., Timsit, J., Grunfeld, J. P., Halbwachs-Mecarelli, L. (1999) A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J. Am. Soc. Nephrol. 10, 1224-1233.
10. Rarok, A. A., Stegeman, C. A., Limburg, P. C., Kallenberg, C. G. M. (2002) Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. J. Am. Soc. Nephrol. 13, 2232-2238.
11. Csernok, E., Ernst, M., Schmitt, W., Bainton, D. F., Gross, W. L. (1994) Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clin. Exp. Immunol. 95, 244-250.
12. Charles, L. A., Caldas, M. L. R., Falk, R. J., Terrell, R. S., Jennette, J. C. (1991) Antibodies against granule proteins activate neutrophils in vitro. J. Leukoc. Biol. 50, 539-546.
13. Porges, A. J., Redecha, P. B., Kimberly, W. T., Csemok, E., Gross, W. L., Kimberly, R. P. (1994) Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via FcγRIIa. J. Immunol. 153, 1271-1280.
14. Reumaux, D., Vossebeld, P. J. M., Roos, D., Verhoeven, A. J. (1995) Effect of TNF-induced integrin activation on FcγReceptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood 86, 3189-3195.
15. Harper, L., Radford, D., Plant, T., Drayson, M., Adu, D., Savage, C. O. S. (2001) IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytoplasmic antibody-positive patients. Arthritis Rheum. 44, 921-930.
16. Falk, R. J., Terrell, R. S., Charles, L. A., Jennette, J. C. (1990) Antineutrophil cytoplasmic antibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. USA 87, 4115-4119.
17. Mulder, A. H., Heeringa, P., Brouwer, E., Limburg, P. C., Kallenberg, C. G. M. (1994) Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a FcγRII-dependent process. Clin. Exp. Immunol. 98, 270-278.
18. Harper, L., Cockwell, P., Adu, D., Savage, C. O. (2001) Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Kidney Int. 59, 1729-1738.
19. Kettritz, R., Jennette, J. C., Falk, R. J. (1997) Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils. J. Am. Soc. Nephrol. 8, 386-394.
20. Savage, C. O., Pottinger, B. E., Gaskin, G., Pusey, C. D., Pcarson, J. D. (1992) Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am. J. Pathol. 141, 335-342.
21. Manger, K., Repp, R., Spriewald, B. M., Rascu, A., Geiger, A., Wasmuth, R., Westerdaal, N. A., Wentz, B., Manger, B., Kalden, J. R., van de Winkel, J. G. (1998) Fcγ receptor IIa polymorphism in caucasian patients with systemic lupus erythematosus: association with clinical symptoms. Arthritis Rheum. 41, 1181-1189.
22. Dijstelbloem, H. M., Scheepers, R. H. M., Oost, W. W., Stegeman, C. A., van der Pol, W. L., Sluiter, W. J., Kallenherg, C. G., van de Winkel, J. G., Tervaert, J. W. (1999) Fcγ receptor polymorphisms in Wegener's granulomatosis: risk factors for disease relapse. Arthritis Rheum. 42, 1823-1827.
23. van der Pol, W. L., van de Winkel, J. G. (1998) IgG receptor polymorphisms: risk factors for disease. Immunogenetics 48, 222-232.
24. Dijstelbloem, H. M., van de Winkel, J. G., Kallenherg, C. G. (2001) Inflammation in autoimmunity: receptors for IgG revisited. Trends Immunol. 22, 510-516.
25. van der Geld, Y. M., Limburg, P. C., Kallenberg, C. G. M. (1999) Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies. Clin. Exp. Immunol. 118, 487-496.
26. Brouwer, E., Cohen Tervaert, J. W., Horst, G., Huitema, M. C., van der Giessen, M., Limburg, P. C., Kallenberg, C. G. M. (1991) Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders. Clin. Exp. Immunol 83, 379-386.
27. Cohen Tervaert, J. W., Gohlschmeding, R., Elema, J. D., van der Giessen, M., Huitema, M. G., van der Hent, G. K., The, T. H., von dem Borne, A. E., Kallenherg, C. G. (1990) Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis. Kidney Int. 37, 799-806.
28. Nijhuis, E., Lammers, J. W., Coenderman, L., Coffer, P. J. (2002) Src kinases regulate PKB activation and modulate cytokine and chemoattractant- controlled neutrophil functioning. J. Leukoc. Biol. 71, 115-124.
29. van Pelt, L. J., van Zwieten, R., Weening, R. S., Roos, D., Verhoeven, A. J., Bolscher, B. G. J. M. (1996) Limitations of the use of dihydrorhodamine 123 for flow cytometric analysis of the neutrophil respiratory burst. J Immunol Methods 191, 187-196.
30. Marino, M., Ruvo, M., De Falco, S., Fassina, G. (2000) Prevention of systemic lupus erythomatosus in MRL/lpr mice hy administration of an immunoglobulin-binding peptide. Nat. Biotechnol. 18, 735-739.
31. Tanaka, S., Edberg, J. C., Chatman, W., Fassina, G., Kimberly, R. P. (2003) FcγRIIIb allele-sensitive release of α-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins. J. Immunol. 171, 6090-6096.
32. Kocher, M., Edberg, J. C., Fleit, H. B., Kiberley, R. P. (1998) Antineutrophil cytoplasmic antibodies preferentially engage FcγRIIIb on human neutrophils. J. Immunol. 161, 6909-6914.
33. Porges, A. J., Redecha, P. B., Kimberley, T., Csernok, E., Gross, W. L., Kimberly, R. P. (1994) Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via FcγRIIa. J. Immunol. 153, 1271-1280.
34. Deguchi, Y., Shibata, N., Kishimoto, S. (1990) Enhanced expression of the tumour necrosis in peripheral blood mononuclear cells from patients with systemic vasculitis. Clin. Exp. Immunol. 81, 311-314.
35. Schreiber, A., Busjahn, A., Luft, F. C., Kettritz, R. (2003) Membrane expression of proteinase 3 is genetically determined. J. Am. Soc. Nephrol. 14, 68-75.
36. van Eeden, S. F., Klut, M. E., Walker, B. A. M., Hogg, J. C. (1999) The use of flow cytometry to measure neutrophil function. J Immunol Methods 232, 23-43.
37. Rarok, A. A., Huitema, M. G., van der Leij, M. J., van der Geld, Y. M., Berthold, H., Schmitt, J., Stegeman, C. A., Limburg, P. C., Kallenberg, C. G. (2003) Recombinant proteins to analyze autoantibodies to proteinase 3 in systemic vasculitis. Am. J. Clin. Pathol. 120, 586-595.
38. Ward, R. A., Nakamura, M., McLeish, K. R. (2000) Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flawocytochrome b558-containing granules. J. Biol. Chem. 275, 36713-36719.
39. Reumaux, D. (2002) Anti-Neutrophil Cytoplasm Autoantibodies: Clinical and Functional Studies. University of Amsterdam, Ph.D. thesis, 79-94.
40. Carulli, G. (1996) Applications of flow cytometry in the study of human neutrophil biology and pathology. Hematopathol. Mol. Hematol. 10, 39-61.
41. Walls, R. G., Howard, T. H. (1992) Evidence for a gelsolin-rich labile F-actin pool in human polymorphonuclear leukocytes. Cell Motil. Cytoskeleton 21, 25-37.
42. Bentley, J. K., Reed, P. W. (1981) Activation of superoxide production and differential exocytosis in polymorphonuclear leukocytes by cytochalasins A, B, C, D and E. Effects of various ions. Biochim. Biophys. Acta 678, 238-244.
43. Morimatsu, A., Kawagoshi, A., Yoshida, K., Tamura, M. (1997) Actin enhances the activation of human neutrophil NADPH oxidase in a cell-free system. Biochem. Biophys. Res. Commun. 230, 206-210.
44. Stossel, T. P. (1992) Basic principles and clinical correlates. In Inflammation (J. I. Gallin, I. M. Goldstein, R. Synderman, eds.), New York, NY, Rayen, 459-475.