Long-term ethanol self-administration by cynomolgus macaques alters the pharmacology and expression of GABAA receptors in basolateral amygdala

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 3, 2004, Pages 1071-1079

  Floyd, Donald W ^a   Friedman, David P ^a   Daunais, James B ^a   Pierre, Peter J ^a   Grant, Kathleen A ^a   McCool, Brian A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; MESSENGER RNA; RECEPTOR SUBUNIT;

ADAPTATION; ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; ELECTRIC CURRENT; ELECTROPHORESIS; FEAR; FEMALE; FOREBRAIN; LEARNING; LONG TERM EXPOSURE; MACACA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PHARMACOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ALCOHOLISM; AMYGDALA; ANIMALS; ELECTROPHYSIOLOGY; FEMALE; MACACA FASCICULARIS; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER;

EID: 10044220717     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.072025     Document Type: Article

References (39)

1. Ariwodola OJ, Crowder TL, Grant KA, Daunais JB, Friedman DP, and Weiner JL (2003) Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons. Alcohol Clin Exp Res 27:1632-1639.
2. Bianchi MT and Macdonald RL (2002) Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J Physiol (Lond) 544:3-18.
3. Brinley-Reed M, Mascagni F, and McDonald AJ (1995) Synaptology of prefrontal cortical projections to the basolateral amygdala: an electron microscopic study in the rat. Neurosci Lett 202:45-48.
4. Budygin EA, John CE, Mateo Y, Daunais JB, Friedman DP, Grant KA, and Jones SR (2003) Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study. Synapse 50:266-268.
5. Cagetti E, Liang J, Spigelman I, and Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol 63:53-64.
6. Charlton ME, Sweetnam PM, Fitzgerald LW, Terwilliger RZ, Nestler EJ, and Duman RS (1997) Chronic ethanol administration regulates the expression of GABAA receptor alpha 1 and alpha 5 subunits in the ventral tegmental area and hippocampus. J Neurochem 68:121-127.
7. Davis AM and McCarthy MM (2000) Developmental increase in (3)H-muscimol binding to the gamma-aminobutyric acid(A) receptor in hypothalamic and limbic areas of the rat: why is the ventromedial nucleus of the hypothalamus an exception? Neurosci Lett 288:223-227.
8. Devaud LL, Fritschy JM, and Morrow AL (1998) Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats. Brain Res 796:222-230.
9. Devaud LL, Fritschy JM, Sieghart W, and Morrow AL (1997) Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J Neurochem 69:126-130.
10. Dominguez-Perrot C, Feltz P, and Poulter MO (1996) Recombinant GABAA receptor desensitization: the role of the gamma 2 subunit and its physiological significance. J Physiol (Lond) 497:145-159.
11. Farabollini F, Fluck E, Albonetti ME, and File SE (1996) Sex differences in benzodiazepine binding in the frontal cortex and amygdala of the rat 24 hours after restraint stress. Neurosci Lett 218:177-180.
12. Floyd DW, Jung KY, and McCool BA (2003) Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. J Pharmacol Exp Ther 307:1020-1029.
13. Grobin AC, Papadeas ST, and Morrow AL (2000) Regional variations in the effects of chronic ethanol administration on GABA(A) receptor expression: potential mechanisms. Neurochem Int 37:453-461.
14. Gulinello M, Orman R, and Smith SS (2003) Sex differences in anxiety, sensorimotor gating and expression of the alpha4 subunit of the GABAA receptor in the amygdala after progesterone withdrawal. Eur J Neurosci 17:641-648.
15. Hevers W, Korpi ER, and Luddens H (2000) Assembly of functional alpha6beta3gamma2delta GABA(A) receptors in vitro. Neuroreport 11:4103-4106.
16. Hodge CW, Chappelle AM, and Samson HH (1995) GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcohol Clin Exp Res 19:1486-1493.
17. Hodge CW and Cox AA (1998) The discriminative stimulus effects of ethanol are mediated by NMDA and GABA(A) receptors in specific limbic brain regions. Psychopharmacology 139:95-107.
18. Huntsman MM, Leggio MG, and Jones EG (1996) Nucleus-specific expression of GABA(A) receptor subunit mRNAs in monkey thalamus. J Neurosci 16:3571-3589.
19. Kang MH, Spigelman I, and Olsen RW (1998) Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. Alcohol Clin Exp Res 22:2165-2173.
20. Kumar S, Kralic JE, O'Buckley TK, Grobin AC, and Morrow AL (2003) Chronic ethanol consumption enhances internalization of alphal subunit-containing GABAA receptors in cerebral cortex. J Neurochem 86:700-708.
21. Kumar S, Sieghart W, and Morrow AL (2002) Association of protein kinase C with GABA(A) receptors containing alphal and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J Neurochem 82:110-117.
22. Kushner MG, Abrams K, and Borchardt C (2000) The relationship between anxiety disorders and alcohol use disorders: a review of major perspectives and findings. Clin Psychol Rev 20:149-171.
23. Lim MS and Birnir B (2001) Heterogeneity of functional GABA(A) receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course. Neuropharmacology 40:1034-1043.
24. Matthews DB, Devaud LL, Fritschy JM, Sieghart W, and Morrow AL (1998) Differential regulation of GABA(A) receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex. J Neurochem 70:1160-1166.
25. McCool BA, Frye GD, Pulido MD, and Botting SK (2003) Effects of chronic ethanol consumption on rat GABA(A) and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neurons. Brain Res 963:165-177.
26. McDonald AJ (1987) Organization of amygdaloid projections to the mediodorsal thalamus and prefrontal cortex: a fluorescence retrograde transport study in the rat. J Comp Neurol 262:46-58.
27. McDonald AJ and Culberson JL (1986) Efferent projections of the basolateral amygdala in the opossum, Didelphis virginiana. Brain Res Bull 17:335-350.
28. McDonald AJ and Mascagni F (1997) Projections of the lateral entorhinal cortex to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat. Neuroscience 77:445-459.
29. Mhatre MC, Pena G, Sieghart W, and Ticku MK (1993) Antibodies specific for GABAA receptor alpha subunits reveal that chronic alcohol treatment down-regulates alpha-subunit expression in rat brain regions. J Neurochem 61:1620-1625.
30. Mitsuyama H, Little KY, Sieghart W, Devaud LL, and Morrow AL (1998) GABA(A) receptor alpha1, alpha4 and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics. Alcohol Clin Exp Res 22:815-822.
31. Papadeas S, Grobin AC, and Morrow AL (2001) Chronic ethanol consumption differentially alters GABA(A) receptor alphal and alpha4 subunit peptide expression and GABA(A) receptor-mediated 36 Cl(-) uptake in mesocorticolimbic regions of rat brain. Alcohol Clin Exp Res 25:1270-1275.
32. Pitkanen A, Savander V, and LeDoux JE (1997) Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. Trends Neurosci 20:517-523.
33. Pritchett DB, Luddens H, and Seeburg PH (1989) Type I and type II GABAA-benzodiazepine receptors produced in transfected cells. Science (Wash DC) 245:1389-1392.
34. Sanders SK and Shekhar A (1995) Regulation of anxiety by GABAA receptors in the rat amygdala. Pharmacol Biochem Behav 52:701-706.
35. Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, et al. (2001) Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol 59:1108-1118.
36. Sundstrom-Peromaa I, Smith DH, Gong QH, Sabado TN, Li X, Light A, Wiedmann M, Williams K, and Smith SS (2002) Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nat Neurosci 5:721-722.
37. Vivian JA, Green HL, Young JE, Majerksy LS, Thomas BW, Shively CA, Tobin JR, Nader MA, and Grant KA (2001) Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences. Alcohol Clin Exp Res 25:1087-1097.
38. Weiner JL, Gu C, and Dunwiddie TV (1997) Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat hippocampal CA1 pyramidal neurons. J Neurophysiol 77:1306-1312.
39. Wisden W, Laurie DJ, Monyer H, and Seeburg PH (1992) The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062.