Influence of gender on chronic ethanol-induced alterations in GABA(A) receptors in rats

Brain Research

Volumn 796, Issue 1-2, 1998, Pages 222-230

  Devaud, Leslie L ^a   Fritschy, Jean Marc ^b   Morrow, A Leslie ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Ethanol dependence; Ethanol withdrawal; GABA(A) receptor; Gender; Neuroactive steroid

Indexed keywords

3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BICUCULLINE; DIAZEPAM;

ADAPTATION; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOBLOTTING; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEIZURE THRESHOLD; SEX DIFFERENCE;

ANIMALS; ANTICONVULSANTS; BICUCULLINE; CEREBRAL CORTEX; CONVULSANTS; DESOXYCORTICOSTERONE; DIAZEPAM; DIFFERENTIAL THRESHOLD; DRUG RESISTANCE; ETHANOL; FEMALE; GENE EXPRESSION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES; SEX CHARACTERISTICS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS;

EID: 0032526534     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00357-6     Document Type: Article

References (45)

1. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Concas A., Biggio G. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations. Br. J. Pharmacol. 120:1997;1582-1588.
2. A receptors. Ann. New York Acad. Sci. 707:1993;116-125.
3. E.-E. Baulieu, M. Schumacher, Synthesis and functions of neurosteroids, in: A.R. Genazzani, F. Petraglia, R.H. Purdy (Eds.), The Brain: Source and Target for Sex Steroid Hormones, The Parthenon Publishing Group, New York, 1996, pp. 5-24.
4. A receptor subtypes differentiated by their gamma-subunit variants: prevalence, pharmacology and subunit architecture. Neuropharmacology. 35:1997;1413-1423.
5. A receptors containing the α4-subunit. Prevalence, distribution, pharmacology, and subunit architecture in situ. J. Neurochem. 69:1997;806-814.
6. A receptor. Brain Res. 561:1991;157-161.
7. Brown M.E., Anton R.F., Malcolm R., Ballenger J.C. Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol. Psych. 23:1988;507-514.
8. Crews F., Morrow A.L., Criswell H., Breese G. Effects of ethanol on ion channels. Int. Rev. Neurobiol. 39:1996;283-367.
9. A receptors: effects of ethanol withdrawal. NIAAA Monograph. 29:1995;219-240.
10. Devaud L.L., Purdy R.H., Morrow A.L. The neurosteroid, 3α-hydroxy-5α-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol. Clin. Exp. Res. 19:1995;350-355.
11. A receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis. Mol. Pharmacol. 48:1995;861-868.
12. Devaud L.L., Purdy R.H., Finn D.A., Morrow A.L. Sensitization of γ-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. J. Pharmacol. Exp. Ther. 278:1996;510-517.
13. A receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J. Neurochem. 69:1997;126-130.
14. DeVries D.J., Johnston G.A.R., Ward L.C., Wilce P.A., Shanley B.C. Effects of chronic ethanol inhalation on the enhancement of benzodiazepine binding to mouse brain membranes by GABA. Neurochem. Int. 10:1987;231-235.
15. Frye G.D., McCown T.J., Breese G.R. Differential sensitivity of ethanol withdrawal signs in the rat to γ-aminobutyric acid (GABA) mimetics: blockade of audiogenic seizures but not forelimb tremors. J. Pharmacol. Exp. Ther. 226:1983;720-725.
16. A-receptor subtypes: differential association of the α1 and α3 subunits with serotonergic and GABAergic neurons. Neuroscience. 54:1993;881-892.
17. Gordis E. Alcohol and tolerance. NIAAA Alcohol Alert. 28:1995;1-4.
18. A receptors in the acute and chronic effects of ethanol, Psychopharmacology, 1998, in press.
19. M.E. Hilton, W.B. Clark, Changes in American drinking patterns and problems, 1967-1984, Society, Culture and Drinking Patterns Reexamined, Rutgers Center of Alcohol Studies, New Brunswick, 1991, pp. 156-172.
20. Janis G.C., Mitsuyama H., Devaud L.L., Morrow A.L. Effects of chronic ethanol consumption on 3α,5α-THP levels in rats: measurement by radioimmunoassay. Alcohol. Clin. Exp. Res. 21:1997;104A.
21. A receptors identify a 67-kDa protein in rat brain membranes. J. Neurochem. 62:1994;764-769.
22. Khanna J.M., Kalant H., Shah G., Chau A. Tolerance to ethanol and cross-tolerance to pentobarbital and barbital in four rat strains. Pharmacol. Biochem. Behav. 39:1991;705-709.
23. Lancaster F.E., Spiegel K.S. Sex differences in pattern of drinking. Alcohol. 9:1992;415-420.
24. Lancaster F.E., Brown T.D., Coker K.L., Elliott J.A., Wren S.B. Sex differences in alcohol preference and drinking patterns emerge during early postpubertal period in Sprague-Dawley rats. Alcohol. Clin. Exp. Res. 20:1996;1043-1049.
25. Lê A.D., Khanna J.M., Kalant H. Effects of chronic treatment with ethanol on the development of cross-tolerance to other alcohols and pentobarbital. J. Pharmacol. Exp. Ther. 263:1992;480-485.
26. Levitan E.S., Schofield P.R., Burt D.R., Rhee L.M., Wisden W., Kohler M., Fujita N., Rodriguez H.F., Stephenson F.A., Darlison M.G., Barnard E.A., Seeburg P.H. Structural and functional basis for GABA receptor heterogeneity. Nature (London). 335:1988;76-79.
27. 3H ]flunitrazepam and Cl-218,872 in cerebellum and cortex of C57Bl mice made tolerant to and dependent upon phenobarbital or ethanol Alcohol. 2:1985;215-220.
28. McGue M., Slutske W., Taylor J., Iacono W.G. Personality and substance use disorders: I. Effects of gender and alcoholism subtype. Alcohol. Clin. Exp. Res. 21:1997;513-520.
29. A receptor alpha subunits reveal that chronic alcohol treatment down-regulates alpha-subunit expression in rat brain regions. J. Neurochem. 61:1993;1620-1625.
30. Middaugh L.D., Frackelton W.F., Boggan W.O., Onofrio A., Shepherd C.L. Gender differences in the effects of ethanol on C57BL/6 mice. Alcohol. 9:1992;257-260.
31. Mihic S.J., Kalant H., Liu J.-F., Wu P.H. Role of the gamma-aminobutyric acid receptor/chloride channel complex in tolerance to ethanol and cross-tolerance to diazepam and pentobarbital. J. Pharmacol. Exp. Ther. 261:1992;108-113.
32. A Receptors and Anxiety: From Neurbiology to Treatment, Raven Press, New York, 1995, pp. 41-56.
33. A receptor subtypes: pharmacological significance and mutational analysis in vivo, in: C. Tanaka, N.G. Bowery (Eds.), GABA: Receptors, Transporters and Metabolism, Birkhauser, Verlag, Basel, 1996, pp. 151-171.
34. A receptor α subunit mRNAs in the rat cerebral cortex. Mol. Pharmacol. 39:1991;157-163.
35. Morrow A.L., Suzdak P.D., Paul S.M. Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur. J. Pharmacol. 142:1987;483-485.
36. - uptake in cerebral cortical synaptoneurosomes J. Pharmacol. Exp. Ther. 246:1988;158-164.
37. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol. Pharmacol. 37:1990;263-270.
38. A receptor α1 and α6 subunit mRNA levels in rat cerebellum. Mol. Cell. Neurosci. 3:1992;251-258.
39. Nutt D.J., Cowen P.J., Green A.R. On the measurement in rats of the convulsant effects of drugs and the changes which follow electroconvulsive shock. Neuropharmacology. 19:1980;1017-1023.
40. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
41. Purdy R.H., Morrow A.L., Moore P.H. Jr., Paul S.M. Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. USA. 88:1991;4553-4557.
42. A and NMDA receptor function in the rat brain. Alcohol. Clin. Exp. Res. 17:1993;115-123.
43. Sellers E.M., Kalant H. Alcohol intoxication and withdrawal. N. Eng. J. Med. 294:1976;757-762.
44. A receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
45. A receptors in rats: analysis of several recognition sites. Alcohol. Clin. Exp. Res. 21:1997;104A. Suppl. 3.