Detection of Antigen-Specific T Cells in Experimental Immune-Mediated Blepharoconjunctivitis in DO11.10 T Cell Receptor Transgenic Mice

Microbiology and Immunology

Volumn 48, Issue 1, 2004, Pages 39-48

  Ozaki, Akemi ^a   Ishida, Waka ^a   Fukata, Kazuyo ^a   Fukushima, Atsuki ^a   Ueno, Hisayuki ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Allergic conjunctivitis; Antigen specific T cell; DO11.10 T cell receptor transgenic mouse

Indexed keywords

CD4 ANTIGEN; EYE DROPS; OVALBUMIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ALLERGIC CONJUNCTIVITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BLEPHARITIS; BLEPHAROCONJUNCTIVITIS; CELL INFILTRATION; CELL KINETICS; CELL PROLIFERATION; CELL STRAIN; CELLULAR IMMUNITY; CONTROLLED STUDY; DOSE RESPONSE; EOSINOPHIL; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; SENSITIZATION; SPLEEN CELL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALIA; MUS MUSCULUS;

EID: 0942297803     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2004.tb03485.x     Document Type: Article

References (23)

1. Bocher, B.S., and Hamid, Q. 2003. Advances in mechanisms of allergy. J. Allergy Clin. Immunol. 111(3 Suppl): 819-823.
2. Cohn, L., Homer, R.J., Marinov, A., Rankin, J., and Bottomly, K. 1997. Induction of airway mucus production by T helper 2 cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186: 1737-1747.
3. Cohn, L., Tepper, J.S., and Bottomly, K. 1998. IL-4-dependent induction of airway hyperresponsiveness by Th2, but not Th1 cells. J. Immunol. 161: 3813-3816.
4. El-Asrar, A.M., Struyf, S., Al-Kharashi, S.A., Missotten, L., Van Damme, J., and Geboes, K. 2002. Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. Br. J. Ophthalmol. 86(10): 1175-1180.
5. Foster, C.S., Rice, B.A., and Dutt, J.E. 1991. Immunopathology of atopic keratoconjunctivitis. Ophthalmology 98: 1190-1196.
6. Fukushima, A., Fukata, K., Ozaki, A., Takata, M., Kuroda, N., Enzan, H., and Ueno, H. 2002. Exertion of the suppressive effects of IFN-gamma on experimental immune mediated blepharoconjunctivitis in Brown Norway rats during the induction phase but not the effector phase. Brit. J. Ophthalmol. 86: 1166-1171.
7. Fukushima, A., Ozaki, A., Fukata, K., and Ueno, H. 2003. Ag-specific recognition, activation and effector function of T cells in the conjunctiva developing experimental immune-mediated blepharoconjunctivitis. Invest. Ophthalmol. Vis. Sci. 44:4366-4374.
8. Hamid, Q.A., and Cameron, L.A. 2000. Recruitment of T cells to the lung in response to antigen challenge. J. Allergy Clin. Immunol. 106(5 Suppl): 227-234.
9. Hansen, G., Berry, G., DeKruyff, R., and Umetsu, D.T. 1999. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103: 175-183.
10. Kamimura, O., Fujimura, H., Fushimi, K., Nakata, A., Sakai, A., Chishima, S., Ogawa, K., Kikuchi, M., Kikkawa, H., Akiyama, K., and Mori, A. 2001. Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation. Eur. J. Immunol. 31: 2669-2679.
11. Kawamoto, T., and Shimizu, M. 2000. A method for preparing 2- to 50-micron-thick fresh-frozen sections of large samples and undecalcified hard tissues. Histochem. Cell Biol. 113(5): 331-339.
12. Leonardi, A., DeFranchis, G., Zancanaro, F., Crivellari, G., De Paoli, M., Plebani, M., and Secchi, A.G. 1999. Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. Invest. Ophthalmol. Vis. Sci. 40(12): 3036-3040.
13. Li, X.M., Schofield, B.H., Wang, Q.F., Kim, K.H., and Huang, S.K. 1998. Induction of pulmonary allergic responses by antigen-specific Th2 cells. J. Immunol. 160: 1378-1384.
14. Metz, D.P., Hingorani, M.k., Calder, V.L., Buckley, R.J., and Lightman, S.L. 1997. T-cell cytokines in chronic allergic eye disease. J. Allergy Clin. Immunol. 100: 817-824.
15. Montan, P.G., Scheynius, A., and van der Ploeg, I. 2002. Similar T helper Th2-like cytokine mRNA expression in vernal keratoconjunctivitis regardless of atopic constitution. Allergy 57: 373-374.
16. + TCRlo thymocytes in vivo. Science 250: 1720-1723.
17. Ozaki, A., Fukushima, A., Fukata, K., and Ueno, H. 2000. Effects of IL-4 and IL-12 on experimental immune-mediated blepharoconjunctivitis in Brown Norway rats. Clin. Exp. Immunol. 122: 28-34.
18. Robertson, J.M., Jensen, P.E., and Evavold, B.D. 2000. DO11.10 and OT-2 T cells recognize a c-terminal ovalbumin 323-339 epitope. J. Immunol. 164: 4706-4712.
19. Trocme, S.D., and Sra, K.K. 2002. Spectrum of ocular allergy. Curr. Opin. Allergy Clin. Immunol. 2(5): 423-427.
20. Uchio, E., Ono, S.Y., Ikezawa, Z., and Ohno, S. 2000. Tear levels of interferon-gamma, interleukin (IL)-2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic kerato-conjunctivitis and allergic conjunctivitis. Clin. Exp. Allergy 30: 103-109.
21. Von Andrian, U.H., and Mackay, C.R. 2000. T-cell function and migration, two sides of the same coin. N. Engl. J. Med. 343:1020-1034.
22. Yoshida, O., Yoshida, H., Iwamoto, H., Nishino, K., Fukushima, A., and Ueno, H. 1999. Genetic background determines the nature of immune responses and experimental immune-mediated blepharoconjunctivitis (EC). Curr. Eye Res. 18: 117-124.
23. Zhan, H., Calder, V., and Lightman, S. 2003. T-cell characterization in chronic allergic eye disease. Curr. Allergy Asthma Rep. 3: 358-362.