Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes

Diabetologia

Volumn 47, Issue 1, 2004, Pages 104-112

  Bloks, V W ^a   Bakker Van Waarde, W M ^a   Verkade, H J ^a   Kema, I P ^a   Wolters, H ^a   Vink, E ^b   Groen, A K ^b   Kuipers, F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

ABC transporters; Bile; Bile salts; Cholesterol absorption; Hepatobiliary transport; Hypercholesterolemia; Intestine; Liver; Phospholipids; Plant sterols; Streptozotocin

Indexed keywords

ABC TRANSPORTER; ABCG5 PROTEIN; ABCG8 PROTEIN; BILE SALT; CAMPESTEROL; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; INSULIN; MESSENGER RNA; SITOSTEROL; STEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; CALCULATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; EXPERIMENTAL DIABETES MELLITUS; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; INTESTINE; INTESTINE ABSORPTION; LIVER; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; INTESTINES; LIPOPROTEINS; LIVER; MALE; PHYTOSTEROLS; RATS; RATS, WISTAR; RNA, MESSENGER; SITOSTEROLS; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 0942279560     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1261-y     Document Type: Article

References (43)

1. Bennion LJ, Grundy SM (1979) Effects of diabetes mellitus on cholesterol metabolism in man. N Engl J Med 296:1365-1371
2. Young NL, Lopez DR, McNamara DJ (1988) Contributions of absorbed dietary cholesterol and cholesterol synthesized in small intestine to hypercholesterolemia in diabetic rats. Diabetes 37:1151-1156
3. Young NL, McNamara DJ, Krasovsky J, Lopez DR, Levy G (1983) Hyperphagia alters cholesterol dynamics in diabetic rats. Diabetes 32:811-819
4. Dietschy JM, Turley SD, Spady DK (1993) Role of liver in maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 34:1637-1659
5. Wilson MD, Rudel LL (1994) Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J Lipid Res 35:943-955
6. Verkade HJ, Vonk RJ, Kuipers F (1995) New insights into the mechanism of bile acid-induced biliary lipid secretion. Hepatology 21:1174-1189
7. Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton, JD, Cohen JC, Hobbs HH (2002) Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 110:671-680
8. Yu L, Hammer RE, Li-Hawkins J, von Bergman K, Lutjohan D, Cohen JC, Hobbs HH (2002) Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 16237-16242
9. Lu K, Lee M-H, Yu H, Zhou Y, Sandell SA, Salen G, Patel SB (2002) Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. J Lipid Res 43:565-578
10. Lee M-H, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB (2001) Identification of a gene, ABCG5, important in the regulation of cholesterol absorption. Nat Gen 27:79-83
11. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH (2000) Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290: 1771-1775
12. Lu K, Lee M-H, Hazard A, Brooks-Wilson A, Hidaka H, Kojima H, Ose L, Stalenhoef AFH, Mietinen T, Bjorkhem I, Brukert E, Pandya A, Brewer HB Jr, Salen G, Dean M, Srivastava A, Patel SB (2001) Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8 respectively. Am J Hum Gen 69:278-290
13. Plösch T, Kok T, Bloks VW, Smit MJ, Havinga R, Chimini G, Groen AK, Kuipers F (2002) Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X-receptor (LXR) is independent of ABCA1. J Biol Chem 277:33870-33877
14. Van Waarde WM, Verkade HJ, Wolters H, Havinga R, Baller J, Bloks VW, Müller M, Sauer PJJ, Kuipers F (2002) Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC transporters in rats. Gastroenterology 122:1842-1852
15. Voshol PJ, Havinga R, Wolters H, Ottenhoff R, Princen HMG, Oude Elferink RPJ, Groen AK, Kuipers F (1998) Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. Gastroenterology 114:1024-1034
16. Kuksis A, Myher JJ, Marai L, Little JA, McArthur RG, Roncari DA (1986) Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia. J Chromatogr 381:1-12
17. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochim Biophys 37:911-917
18. Böttcher CFJ, Gent CM van, Pries C (1961) A rapid and sensitive sub-micro-phosphorus determination. Anal Chim Acta 24:203-204
19. Gamble W, Vaughan M, Kruth MS, Avigan J (1978) Procedure for determination of free and total cholesterol in micro-and nanogram amounts suitable for studies with cultured cells. J Lipid Res 19:1068-1071
20. Wolters H, Spiering M, Gerding A, Slooff MJH, Kuipers F, Hardonk MJ, Vonk RJ (1991) Isolation and characterization of canalicular and basolateral plasma membrane fractions from human liver. Biochim Biophys Acta 1069:61-69
21. Kosters A, Frijters RJJM, Schaap FG, Vink E, Plösch T, Ottenhoff R, Jirsa M, De Cuyper IM, Kuipers F, Groen AK (2003) Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol 38:710-716
22. Bloks VW, Plösch T, Goor H van, Roelofsen H, Baller J, Havinga R, Verkade HJ, Tol A van, Jansen PLM, Kuipers F (2001) Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice. J Lipid Res 42:41-50
23. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6:986-994
24. Salen G, Shefer S, Nguyen L, Ness GC, Tint S, Shore V (1992) Sitosterolemia. J Lipid Res 33:945-955
25. Lee MH, Lu K, Patel SB (2001) Genetic basis of sitosterolemia. Curr Opin Lipidol 12:141-149
26. Salen G, Shore V, Tint S, Forte T, Shefer S, Horak I, Horak E, Dayal B, Nguyen L, Batta AK (1989) Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J Lipid Res 30:1319-1330
27. Bhattacharyya AK, Connor WE, Lin DS, McMurry MM, Shulman RS (1991) Sluggish sitosterol turnover and hepatic failure to excrete sitosterol into bile cause expansion of body pool of sitosterol in patients with sitosterolemia and xanthomatosis. Arterioscler Thromb 11:1287-1294
28. Remaley AT, Bark S, Walts AD, Freeman L, Shulenin S, Annilo T, Elgin E, Rhodes HE, Joyce C, Dean M, Santamaria-Fojo S, Brewer HB Jr (2002) Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem Biophys Res Commun 295:276-282
29. Repa JJ, Berge KE, Pomajzl C, Richardson, Hobbs H, Mangelsdorf DJ (2002) Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β. J Biol Chem 277:18793-18800
30. Repa JJ, Mangelsdorf DJ (2002) The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 8:1243-1248
31. Graf GA, Li WP, Gerard RD, Gelissen I, White A, Cohen JC, Hobbs HH (2002) Coexpression of ATP binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest 110:659-669
32. Ji Y, Wang N, Ramakrishnan R, Sehayek E, Huszar D, Breslow JL, Tall AR (1999) Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem 274: 33398-33402
33. Mardones P, Quinones V, Amigo L, Moreno M, Miquel JF, Schwarz M, Miettinen HE, Krieger M, VanPatten S, Cohen DE, Rigotti A (2001) Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J Lipid Res 42: 170-180
34. Kozarsky KF, Donahee MA, Rigotti A, Iqbal SN, Edelman ER, Krieger M (1997) Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 387:414-417
35. Groen AK, Bloks VW, Bandsma RHJ, Ottenhoff R, Chimini G, Kuipers F (2001) Hepatobiliary cholesterol transport is not impaired in ABCA1 null mice lacking high density lipoproteins. J Clin Invest 108:843-850
36. Schedl HP, Wilson HD (1971) Effects of diabetes on intestinal growth in the rat. J Exp Zool 176:487-496
37. Suckling KE, Stange EF (1985) Role of acylCoA cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26:647-671
38. Tobin KAR, Ulven SM, Schuster GU, Hermansen Steiniger H, Andresen SM, Gustafsson JA, Nebb HI (2002) Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem 277:10691-10697
39. Uehara Y, Engel T, Li Z, Goepfert C, Rust S, Zhou X, Langer C, Schachtrup C, Wiekowski J, Lorowski S, Assmann G, von Eckardstein A (2002) Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1. Diabetes 51:2922-2982
40. Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS (2001) Unsaturated fatty acids inhibit transcription of the sterol regulatory element binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent acitvation of the LXR. Proc Natl Acad Sci USA 98:6027-6032
41. Yoshikawa T, Shimano H, Yahagi N, Ide T, Amamiya-kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N (2002) Polyunsaturated fatty acids suppress sterol regulatory elemnent-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 277:1705-1711
42. Kojima H, Hidaka H, Matsumura K, Fujita Y, Yamada S, Haneda M, Yasuda H, Kikkawa R, Kashiwagi A (1999) Effect of glycemic control on plasma plant sterol levels and post-heparin diamine oxidase activity in type 1 diabetic patients. Atherosclerosis 145:389-397
43. Sudhop T, Gottwald BM, von Bergman K (2002) Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism 51:1519-1521