Blockade of the sympathetic nervous system degrades ligament in a rat MCL model

Journal of Applied Physiology

Volumn 96, Issue 2, 2004, Pages 711-718

  Dwyer, Kelley W ^a,b   Provenzano, Paolo P ^a,b   Muir, Peter ^a   Valhmu, Wilmot B ^a   Vanderby Jr , Ray ^a,b,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Wisconsin Madison   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Guanethidine; Medial collateral ligament; Neuropeptide; Tissue engineering; Tissue mechanics

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CATHEPSIN K; COLLAGENASE 3; CYSTEINE PROTEINASE; GUANETHIDINE; MATRIX METALLOPROTEINASE; NEUROPEPTIDE Y; NORADRENALIN; TOXIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVITY; FEMALE; HISTOLOGY; KNEE LIGAMENT; LIGAMENT DISEASE; MECHANICS; NONHUMAN; NORADRENALIN BLOOD LEVEL; NUCLEOTIDE SEQUENCE; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPATHETIC BLOCKING; SYMPATHETIC TONE; TISSUE ENGINEERING; VASCULARIZATION;

ACID PHOSPHATASE; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CATHEPSINS; COLLAGENASES; FEMALE; GUANETHIDINE; ISOENZYMES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MEDIAL COLLATERAL LIGAMENT, KNEE; NEUROPEPTIDE Y; NOREPINEPHRINE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; SUBSTANCE P; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOLYTICS; TISSUE ENGINEERING; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0942265990     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00307.2003     Document Type: Article

References (44)

1. Ackermann PW, Ahmed M, and Kreicbergs A. Early nerve regeneration after Achilles tendon rupture-a prerequisite for healing? A study on the rat. J Orthop Res 20: 849-856, 2002.
2. Ackermann PW, Li J, Finn A, Ahmed M, and Kreicbergs A. Autonomic innervation of tendons, ligaments and joint capsules. A morphologic and quantitative study in the rat. J Orthop Res 19: 372-378, 2001.
3. Barka T and Anderson PJ. Phosphatases; esterases. In: Histochemistry: Theory, Practice, and Bibliography. New York: Harper & Row, 1963, p. 212-269.
4. Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, and Levy MA. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem 271: 12517-12524, 1996.
5. Bray R, Forrester K, McDougall JJ, Damji A, and Ferrell WR. Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits. Med Biol Eng Comput 34: 227-231, 1996.
6. Bray RC, Butterwick DJ, Doschak MR, and Tyberg JV. Coloured microsphere assessment of blood flow to knee ligaments in adult rabbits: effects of injury. J Orthop Res 14: 618-625, 1996.
7. Bray RC, Leonard CA, and Salo PT. Vascular physiology and long-term healing of partial ligament tears. J Orthop Res 20: 984-989, 2002.
8. Domon S, Shimokawa H, Matsumoto Y, Yamaguchi S, and Soma K. In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement. Arch Oral Biol 44: 907-915, 1999.
9. Everts V, van der Zee E, Creemers L, and Beertsen W. Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling. Histochem J 28: 229-245, 1996.
10. Felten DL, Felten SY, and Bellinger DL. Noradrenergic sympathetic neural interations with the immune system: structure and function. Immunol Rev 100: 225-258, 1987.
11. Ferrell WR, McDougall JJ, and Bray RC. Spatial heterogeneity of the effects of calcitonin gene-related peptide (CGRP) on the microvasculature of ligaments in the rabbit knee joint. Br J Pharmacol 121: 1397-1405, 1997.
12. Field J and Atkins RM. Effect of guanethidine on the natural history of post-traumatic algodystrophy. Ann Rheum Dis 52: 467-469, 1993.
13. Gado K and Emery P. Intra-articular guanethidine injection for resistant shoulder pain: a preliminary double blind study of a novel approach. Ann Rheum Dis 55: 199-201, 1996.
14. Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQueney MS, Foged NT, Delmas PD, and Delaisse JM. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem 273: 32347-32352, 1998.
15. Gomori G. Enzymes. In: Microscopic Histochemistry: Principles and Practices. Chicago, IL: The University of Chicago Press, 1952, p. 137-221.
16. Halleen JM, Raisanen S, Salo JJ, Reddy SV, Roodman GD, Hentunen TA, Lehenkari PP, Kaija H, Vihko P, and Vaananen HK. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem 274: 22907-22910, 1999.
17. Hart DA, Reno C, Frank C, and Shrive N. Pregnancy affects cellular activity, but not tissue mechanical properties, in the healing rabbit medial collateral ligament. J Orthop Res 18: 462-471, 2000.
18. Hart DA, Sciore P, Boykiw R, and Reno C. Pregnancy induces complex changes in the pattern of mRNA expression in knee ligaments of the adolescent rabbit. Matrix Biol 17: 21-34, 1998.
19. Hellio Le Graverand MP, Eggerer J, Sciore P, Reno C, Vignon E, Otterness I, and Hart DA. Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury. Matrix Biol 19: 431-441, 2000.
20. Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, Keysser M, Keyszer G, and Bromme D. Cathepsin K is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol 159: 2167-2177, 2001.
21. Hurschler C, Loitz-Ramage B, and Vanderby R Jr. A structurally based stress-stretch relationship for tendon and ligament. J Biomech Eng 119: 392-399, 1997.
22. Ivie TJ, Bray RC, and Salo PT. Denervation impairs healing of the rabbit medial collateral ligament. J Orthop Res 20: 990-995, 2002.
23. Kafienah W, Bromme D, Buttle DJ, Croucher LJ, and Hollander AP. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J 331: 727-732, 1998.
24. Kirschenbaum HL and Rosenberg JM. What to look out for with guanethidine and reserpine. RN 47: 31-33, 1984.
25. Knittel T, Mehde M, Kobold D, Saile B, Dinter C, and Ramadori G. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol 30: 48-60, 1999.
26. McDougall JJ, Ferrell WR, and Bray RC. Spatial variation in sympathetic influences on the vasculature of the synovium and medial collateral ligament of the rabbit knee joint. J Physiol 503: 435-443, 1997.
27. Muir P, Hayashi K, Manley PA, Colopy SA, and Hao Z. Evaluation of tartrate-resistant acid phosphatase and cathepsin K in ruptured canine cranial cruciate ligament. Am J Ver Res 63: 1279-1284, 2002.
28. Nagase H and Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 274: 21491-21494, 1999.
29. Nakase T, Takeuchi E, Sugamoto K, Kaneko M, Tomita T, Myoui A, Uchiyama Y, Ochi T, and Yoshikawa H. Involvement of multinucleated giant cells synthesizing cathepsin K in calcified tendinitis of the rotator cuff tendons. Rheumatology (Oxford) 39: 1074-1077, 2000.
30. Provenzano PP, Hayashi K, Kunz DN, Markel MD, and Vanderby R Jr. Healing of subfailure ligament injury: comparison between immature and mature ligaments in a rat model. J Orthop Res 20: 975-983, 2002.
31. Quinn CO, Scott DK, Brinckerhoff CE, Matrisian LM, Jeffrey JJ, and Partridge NC. Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. Semin Oncol 29: 78-86, 2002.
32. Reno C, Boykiw R, Martinez ML, and Hart DA. Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament. Biochem Biophys Res Commun 252: 757-763, 1998.
33. Saftig P, Hunziker E, Everts V, Jones S, Boyde A, Wehmeyer O, Suter A, and von Figura K. Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice. Adv Exp Med Biol 477: 293-303, 2000.
34. Salo PT, Hogervorst T, Seerattan RA, Rucker D, and Bray RC. Selective joint denervation promotes knee osteoarthritis in the aging rat. J Orthop Res 20: 1256-1264, 2002.
35. Schaffer M, Beiter T, Becker HD, and Hunt TK. Neuropeptides: mediators of inflammation and tissue repair? Arch Surg 133: 1107-1116, 1998.
36. Tsuji Y, Yamaza T, Kido MA, Goto T, Nakata S, Akamine A, Nakasima A, and Tanaka T. Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy. Cell Tissue Res 303: 359-369, 2001.
37. Uusitalo H, Hiltunen A, Soderstrom M, Aro HT, and Vuorio E. Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus. Calcif Tissue Int 67: 382-390, 2000.
38. Wahren LK, Gordh T Jr, and Torebjork E. Effects of regional intravenous guanethidine in patients with neuralgia in the hand; a follow-up study over a decade. Pain 62: 379-385, 1995.
39. Wells GM, Catlin G, Cossins JA, Mangan M, Ward GA, Miller KM, and Clements JM. Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multi-competitor cDNA standard. Glia 18: 332-340, 1996.
40. Winocur E, Gavish A, Halachmi M, Eli I, and Gazit E. Topical application of capsaicin for the treatment of localized pain in the temporomandibular joint area. J Orofac Pain 14: 31-36, 2000.
41. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5: 2145-2154, 1991.
42. Woo SL. Effects of postmortem storage by freezing on ligament tensile behavior. J Biomech 19: 399-404, 1986.
43. Yamashita DS and Dodds RA. Cathepsin K and the design of inhibitors of cathepsin K. Curr Pharm Des 6: 1-24, 2000.
44. Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Rose W, Rone J, Movafagh S, Ji H, Yeh Y, Chen WT, Kleinman HK, Grouzmann E, and Grant DS. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ Res 83: 187-195, 1998.