Analysis of age dependent changes of Topoisomerase II α and β in rat brain

International Journal of Developmental Neuroscience

Volumn 22, Issue 1, 2004, Pages 19-30

  Kondapi, Anand K ^a   Mulpuri, Neelima ^a   Mandraju, R K ^a   Sasikaran, B ^b   Rao, K Subba ^a  

^a UNIVERSITY OF HYDERABAD   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

Ageing; Brain; Cerebellum; Neurons; Topoisomerase II

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; DNA TOPOISOMERASE (ATP HYDROLYSING) BETA; ISOPROTEIN; UNCLASSIFIED DRUG;

AGE; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN LEVEL; BRAIN NERVE CELL; BRAIN REGION; BRAIN TISSUE; CELL FRACTIONATION; CEREBELLUM; CONTROLLED STUDY; EMBRYO; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRENATAL PERIOD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

EUKARYOTA;

EID: 0842348088     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2003.10.006     Document Type: Article

References (21)

1. Asami Y., Jia D.W., Tatebayashi K., Yamagata K., Tanokura M., Ikeda H. Effect of the DNA Topoisomerase II inhibitor VP-16 on illegitimate recombination in yeast chromosomes. Gene. 291:2002;251-257.
2. Brook P.J. Detection of excition nuclease in cell free extracts from the adult mammalian brain. Mutat. Res. 408:1998;37-46.
3. Capranico G., Tinelli S., Austin C.A., Fisher M., Zunino F. Different patterns of gene expression of Topoisoemrase II isoforms in differentiated tissues during murine development. Biochem. Biophys. Acta. 1132:1992;43-48.
4. Chaly N., Chen X., Dentry J., Brown D.L. Organization of DNA Topoisomerase II isotypes during the cell cycle of human lymphocytes and HeLa cells. Chromosome Res. 4:1996;457-466.
5. Drake F.H., Hofmann G.A. Biochemical and pharmacological properties of p170 and p180 forms of Topoisomerase II. Biochemistry. 28:1989;8154-8160.
6. Franchitto A., Pichierri P., Mosesso P., Palitti F. Catalytic inhibition of topoisomerase II in Werner's syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of the cell cycle. Int. J. Radiat. Biol. 76:2000;913-922.
7. Gopal Y.V.N., Jayaraju D., Kondapi A.K. Inhibition of Topoisomerase II catalytic activity by two ruthenium compounds: a ligand dependent mode of action. Biochemistry. 38:1999;4382-4388.
8. 6)(dmso)]. Arch. Biochem. Biophys. 401:2002;53-62.
9. Isaacs R.J., Davies S.L., Sandri M.I., Redwood C., Wells N.J., Hickson I.D. Physiological regulation of eukaryotic topoisomerase II. Biochim. Biophys. Acta. 1400:1998;121-137.
10. Ishii Y., Ikushima T. Post treatment effects of DNA Topoisomerase inhibitors on UVB and X-ray induced chromosomal aberration formation. Mutat. Res. 25:2002;67-74.
11. Jurenke J.M., Holden J.A. Distribution of DNA Topoisomerase II isoforms in differentiated adult mouse. Tissue Biochem. Biophys. Acta. 1216:1993;191-196.
12. Kohji, T., Hayashi, M., Shioda, K., Minagaw, M., Morimatsu, Y., Tamagawa, K.O.M., 1998. Cerebellar neurodegeneration in human hereditary DNA repair disorders. Neurosci. Lett. 243, 133-136.
13. Pastor N., Cortes F. DNA Topoisomerase activities in Chinese hamster radiosensitive mutants after X-ray treatment. Cell Biol. Int. 26:2002;547-555.
14. Rao K.S. Base excision repair (BER) and the brain. J. Biochem. Mol. Biol. Biophys. 6:2002;71-83.
15. Rao K.S., Annapurna V.V., Raji N.S., Harikrishna T. Loss of base excision repair in aging rat neurons and its restoration by DNA polymerase beta. Brain Res. Mol. Brain Res. 85:2000;251-259.
16. Tsutsui K., Tsutsui K., Hosoya O., Sano K., Tokunaga A. Immunohistochemical analysis of DNA Topoisomerase II isoforms in developing rat cerebellum. J. Comp. Neurol. 431:2001;228-239.
17. Tsutsui K., Tsutsui K., Okada S., Watanabe M., Toshikiyo Sheyi S., Yoshiso S. Molecular cloning of partial cDNAs for Rat Dna Topoisomerase II isoforms and their differential expression in brain development. J. Biol. Chem. 268:1993;19076-19083.
18. Usha Rani B., Singh N.I., Ray A., Rao K.S. Procedure for isolation of neuron- and astrocyte-enriched fractions from chick brain of different ages. J. Neurosci. Res. 10:1983;101-105.
19. Wang J.C. DNA topoisomerases. Annu. Rev. Biochem. 65:1996;635-692.
20. Woessner R.D., Chung T.D.Y., Drake F.H. Proliferation and cell cycle dependent differences in expression of the 170 and 180 KDa forms of Topoisomerase II. Cell Growth Differ. 2:1991;209-214.
21. Wu, L., Karow, J.K., Hickson, I.D., 1999. Genetic recombination: helicases and Topoisomerases link up. Curr. Biol. 9, R518-R520.