Post-treatment effects of DNA topoisomerase inhibitors on UVB- and X-ray-induced chromosomal aberration formations

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 504, Issue 1-2, 2002, Pages 67-74

  Ishii, Y ^a   Ikushima, T ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY OF EDUCATION   (Japan)

Author keywords

Chromosomal aberration; DNA topoisomerase inhibitor; ICRF 193; Nogalamycin; UVB; X rays

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; NOGALAMYCIN; PHYTOHEMAGGLUTININ;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL STRAIN V 79; CHROMATID EXCHANGE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DNA DAMAGE; DRUG EFFECT; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE ACTIVATION; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; TIME; ULTRAVIOLET B RADIATION; X IRRADIATION;

ANIMALS; CELL CYCLE; CELL LINE; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HUMANS; LYMPHOCYTES; MALE; NOGALAMYCIN; NUCLEIC ACID SYNTHESIS INHIBITORS; PIPERAZINES; RING CHROMOSOMES; TIME FACTORS; ULTRAVIOLET RAYS;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037173445     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00080-5     Document Type: Article

References (30)

1. DNA topoisomerases
2. DNA topoisomerases
3. DNA topoisomerase poisons as antitumor drugs
4. DNA topoisomerases: Essential enzymes and lethal targets
5. Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells
6. Induction of sister chromatid exchanges by inhibitors of topoisomerases
7. +/--3.7.2C mouse lymphoma cells
8. Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: Possible role of topoisomerase
9. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells
10. Cell cycle depedence of sister chromatid exchange induction by DNA topoisomerase II inhibitors in Chinese hamster V79 cells
11. Topoisomerase I activity and cellular response to radiation in Chinese hamster cells
12. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives
13. Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors
14. Effects of an inhibitor of topoisomerase II, ICRF-193 on the formation of ultraviolet-induced chromosomal aberrations
15. Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar
16. Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: A potential role of ligand-induced DNA binding at a distal site
17. Bimodal induction of sister-chromatid exchanges by luminol, an inhibitor of poly(ADP-ribose) synthetase, during the S-phase of the cell cycle
18. New Giemsa method for the differential staining of sister chromatids
19. 2-dependent DNA double-strand break repair in the formation of ultraviolet light B-induced chromosomal aberrations
20. Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents
21. BISACK analysis of the phytohaemagglutinin-induced proliferation of human peripheral lymphocytes
22. Proliferative kinetics of human lymphocytes in culture measured by autoradiography and sister chromatid differential staining
23. 2-M delay
24. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase
25. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
26. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation
27. DNA-dependent kinase (P350) as a candidate gene for the murine SCID defect
28. Further characterization of the radiosensitivity of the SCID mouse
29. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
30. Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange