Mitochondria as a Target of Cadmium Nephrotoxicity: Induction of Swelling and Cytochrome c Release

Toxicology Mechanisms and Methods

Volumn 14, Issue 1-2, 2004, Pages 67-71

  Lee, Wing Kee ^a,b   Bork, Ulrich ^a   Thévenod, Frank ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Apoptosis; Cytochrome c; Permeability Transition; Proximal Tubule

Indexed keywords

CADMIUM; CYTOCHROME C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL DEATH; CELL SWELLING; CENTRIFUGATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NEPHROTOXICITY; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT; TARGET CELL;

ANIMALIA;

EID: 0842327463     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376520490257509     Document Type: Conference Paper

References (23)

1. Al-Nasser, I. A. 2000. Cadmium hepatotoxicity and alterations of the mitochondrial function. J. Toxicol. Clin. Toxicol. 38:407-413.
2. Beavis, A. D., Brannan, R. D., and Garlid, K. D. 1985. Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume. J. Biol. Chem. 260:13424-13433.
3. Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., and Zoratti, M. 1992. Modulation of the mitochondrial permeability transition pore: effect of protons and divalent cations. J. Biol. Chem. 267:2934-2939.
4. Bernardi, P. 1999. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol. Rev. 79:1127-1155.
5. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-252.
6. Cain, K., Bratton, S. B., and Cohen, G. M. 2002. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84:203-214.
7. Chavez, E., Briones, R., Michel, B., Bravo, C., and Jay, D. 1985. Evidence for the involvement of dithiol groups in mitochondrial calcium transport: studies with cadmium. Arch. Biochem. Biophys. 242:493-497.
8. Crompton, M., Barksby, E., Johnson, N., and Capano, M. 2002. Mitochondrial intermembrane junctional complexes and their involvement in cell death. Biochimie 84:143-152.
9. Desagher, S., and Martinou, J. C. 2000. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10:369-377.
10. Du, C., Fang, M., Li, Y., Li, L., and Wang, X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33-42.
11. Halestrap, A. P., McStay, G. P., and Clarke, S. J. 2002. The permeability transition pore complex: another view. Biochimie 84:153-166.
12. Klaassen, C. D., Liu, J., and Choudhuri, S. 1999, Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39:267-294.
13. 2+ effects on respiration and swelling of rat liver mitochondria were modified by monovalent cations. J. Inorg. Biochem. 70:17-23.
14. Leist, M., and Jäättelä, M. 2001. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2:1-10.
15. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86:147-157.
16. Majno, G., and Joris, I. 1995. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:3-15.
17. Nordberg, M., Jin, T., and Nordberg, G. F. 1992. Cadmium, metallothionein and renal tubular toxicity. IARC Sci. Publ. 118:293-297.
18. Shimizu, S., Ide, T., Yanagida, T., and Tsujimoto, Y. 2000. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J. Biol. Chem. 275:12321-12325.
19. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffier, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446.
20. +-ATPase through proteasomal and endo-/lysosomal proteolytic pathways. FASEB J. 13:1751-1761.
21. Thévenod, F., Friedmann, J. M., Katsen, A. D., and Hauser, I. A. 2000. Upregulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J. Biol. Chem. 275:1887-1896.
22. Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., and Vaux, D. L. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43-53.
23. Wyllie, A. H., and Golstein, P. 2001. More than one way to go. Proc. Natl. Acad. Sci. U S A 98:11-13.