Crystallographic Studies on Structural Features That Determine the Enzymatic Specificity and Potency of Human Angiogenin: Thr44, Thr80, and Residues 38-41

Biochemistry

Volumn 43, Issue 5, 2004, Pages 1230-1241

  Holloway, Daniel E ^a   Chavali, Gayatri B ^a,c   Hares, Michelle C ^a   Baker, Matthew D ^a   Subbarao, Gowtham V ^a   Shapiro, Robert ^b   Acharya, K Ravi ^a  

^a University of Bath   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BLOOD VESSELS; CATALYST ACTIVITY; CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROGEN BONDS;

ANGIOGENIC ACTIVITY; NUCLEAR TRANSLOCATION;

ENZYME KINETICS;

ANGIOGENIN; ASPARTIC ACID; CYTIDINE DERIVATIVE; NUCLEOTIDE; PYRIMIDINE; RIBONUCLEASE; THREONINE;

ANGIOGENESIS; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHIMERA; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; CATTLE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; RIBONUCLEASE, PANCREATIC; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THREONINE;

EID: 0842327140     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035654+     Document Type: Article

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