Synthesis and evaluation of stereopure α-trifluoromethyl-malic hydroxamates as inhibitors of matrix metalloproteinases

Tetrahedron Letters

Volumn 45, Issue 8, 2004, Pages 1611-1615

  Sani, Monica ^a,b   Belotti, Dorina ^c   Giavazzi, Raffaella ^c   Panzeri, Walter ^b   Volonterio, Alessandro ^a   Zanda, Matteo ^b  

^a POLITECNICO DI MILANO   (Italy)

^b CNR   (Italy)

^c MARIO NEGRI INST PHARMACOL RES   (Italy)

Author keywords

Fluorine; Matrix metalloproteinases; Peptidomimetics

Indexed keywords

GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; OXAZOLIDINE DERIVATIVE;

ALDOL REACTION; ARTICLE; DIASTEREOISOMER; DRUG POTENCY; DRUG SYNTHESIS; EPIMERIZATION; IC 50; REACTION OPTIMIZATION; SAPONIFICATION; SOLVENT EFFECT; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 0842326690     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.12.131     Document Type: Article

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