Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats

Neuropathology and Applied Neurobiology

Volumn 30, Issue 1, 2004, Pages 80-89

  Ibanez, C ^a   Shields, S A ^b   El Etr, M ^a   Baulieu, E E ^a   Schumacher, M ^a   Franklin, R J M ^b  

^a INSERM   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Ageing; Myelin; Neurosteroids; Oligodendrocytes; Regeneration

Indexed keywords

ETHIDIUM BROMIDE; PROGESTERONE;

AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; DRUG EFFECT; HISTOCHEMISTRY; HORMONE ACTION; MALE; NERVE FIBER; NERVE FIBER REGENERATION; NERVE LESION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; SCHWANN CELL;

AGING; ANIMALS; BRAIN; DELAYED-ACTION PREPARATIONS; DEMYELINATING DISEASES; ETHIDIUM; MALE; NEUROTOXINS; OLIGODENDROGLIA; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0842308720     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0305-1846.2003.00515.x     Document Type: Article

References (39)

1. Jeffery ND, Blakemore WF. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 1997; 120: 27-37
2. Smith EJ, Blakemore WF, McDonald WI. Central remyelination restores secure conduction. Nature 1979; 280: 395-6
3. Kornek B, Storch MK, Weissert R, Wallstroem E, Strefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000; 157: 267-76
4. Lovas G, Szilagyi N, Majtenyi K, Palkovits M, Komoly S. Axonal changes in chronic demyelinated cervical spinal cord plaques. Brain 2000; 123: 308-17
5. Blakemore WF, Franklin RJM. Transplantation options for therapeutic central nervous system remyelination. Cell Transplant 2000; 9: 289-94
6. Zhang SC, Duncan ID. Remyelination and restoration of axonal function by glial cell transplantation. Prog Brain Res 2000; 127: 515-33
7. Pavelko KD, van Engelen BG, Rodriguez M. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J Neurosci 1998; 18: 2498-505
8. Warrington AE, Asakura K, Bieber AJ, Ciric B, Van Keulen V, Kaveri SV, Kyl RA, Pease LR, Rodriguez M. Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis. Proc Natl Acad Sci USA 2000; 97: 6820-5
9. Cannella B, Hoban CJ, Gao YL, Garcia-Arenas R, Lawson D, Marchionni M, Gwynne D, Raine CS. The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis. Proc Natl Acad Sci USA 1998; 95: 10100-5
10. Yao DL, Liu X, Hudson LD, Webster HD. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 1995; 92: 6190-4
11. Liu X, Linnington C, Webster HD, Lassmann S, Yao DL, Hudson LD, Wekerle H, Kreutzberg GW. Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis. J Neurosci Res 1997; 47: 531-8
12. O'Leary MT, Hinks GL, Charlton HM, Franklin RJM. Increasing Local Levels of IGF-I mRNA Expression Using Adenoviral Vectors Does Not Alter Oligodendrocyte Remyelination in the CNS of Aged Rats. Mol Cell Neurosci 2002; 19: 32-42
13. Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997; 3: 1209-15
14. Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res 1997; 52: 1-32
15. Koenig HL, Schumacher M, Ferzaz B, Thi AN. Ressouches A, Guennoun R, Jung-Testas I, Robel P, Akwa Y, Baulieu EE. Progesterone synthesis and myelin formation by Schwann cells. Science 1995; 268: 1500-3
16. Chan JR, Phillips LJ II, Glaser M. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci USA 1998; 95: 10459-64
17. Desarnaud F, Do Thi AN, Brown AM, Lemke G, Suter U, Baulieu EE, Schumacher M. Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells. J Neurochem 1998; 71: 1765-8
18. Guennoun R, Benmessahel Y, Delespierre B, Gouezou M, Rajkowski KM, Baulieu EE, Schumacher M. Progesterone stimulates Krox-20 gene expression in Schwann cells. Brain Res Mol Brain Res 2001; 90: 75-82
19. Jung-Testas I, Schumacher M, Robel P, Baulieu EE. The neurosteroid progesterone increases the expression of myelin proteins (MBP and CNPase) in rat oligodendrocytes in primary culture. Cell Mol Neurobiol 1996; 16: 439-43
20. Verdi JM, Campagnoni AT. Translational regulation by steroids. Identification of a steroid modulatory element in the 5′-untranslated region of the myelin basic protein messenger RNA. J Biol Chem 1990; 265: 20314-20
21. Jung-Testas I, Baulieu EE. Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system. J Steroid Biochem Mol Biol 1998; 65: 243-51
22. Drew PD, Chavis JA. Female sex steroids: effects upon microglial cell activation. J Neuroimmunol 2000; 111: 77-85
23. Ganter S, Northoff H, Mannel D, Gebicke-Harter PJ. Growth control of cultured microglia. J Neurosci Res 1992; 33: 218-30
24. Blakemore WF, Crang AJ, Franklin RJM, Tang K, Ryder S. Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS. Glia 1995; 13: 79-91
25. Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJM. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 2001; 35: 204-12
26. Ludwin SK. Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest 1980; 43: 382-7
27. Smith PM, Franklin RJM. The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination. J Neuroimmunol 2001; 119: 261-8
28. Woodruff RH, Franklin RJM. Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study. Glia 1999; 25: 216-28
29. Shields SA, Gilson JM, Blakemore WF, Franklin RJM. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination. Glia 1999; 28: 77-83
30. Sim FJ, Hinks GL, Franklin RJM. The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain. Neuroscience 2000; 100: 131-9
31. Liere P, Akwa Y, Weill-Engerer S, Eychenne B, Pianos A, Robel P, Sjovall J, Schumacher M, Baulieu EE. Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatographymass spectrometry. J Chromatogr B Biomed Sci Appl 2000; 739: 301-12
32. Sim FJ, Zhao C, Penderis J, Franklin RJM. The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J Neurosci 2002; 22: 2451-9
33. Franklin RJM, Zhao C, Sim FJ. Ageing and CNS remyelination. Neuroreport 2002; 13: 923-8
34. Gago N, Akwa Y, Sananes N, Guennoun R, Baulieu EE, ElEtr M, Schumacher M. Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolism. Glia 2001; 36: 295-308
35. Baulieu EE. Contragestion and other clinical applications of RU 486. an antiprogesterone at the receptor. Science 1989; 245: 1351-7
36. Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy Multiple Sclerosis Group. N Engl J Med 1998; 339: 285-91
37. Hoffman GE, Le WW, Murphy AZ, Koski CL. Divergent effects of ovarian steroids on neuronal survival during experimental allergic encephalitis in Lewis rats. Exp Neurol 2001; 171: 272-84
38. Stein DG. Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? Trends Neurosci 2001; 24: 386-91
39. Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M. Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine 1999; 24: 2134-8