Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4793-4800

  Gallardo, T ^a   Zafra Polo, M C ^a   Tormo, J R ^a   Carmen Gonzalez M ^a   Franck, X ^b   Estornell, E ^a   Cortes, D ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOGENIN; ALKYL GROUP; ANTINEOPLASTIC AGENT; FUNCTIONAL GROUP; GUANACONE; LACTONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROLLINIASTATIN 1; SQUAMOCIN; TETRAHYDROFURAN DERIVATIVE; UBIQUINONE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG SYNTHESIS; ENERGY METABOLISM; ENZYME INHIBITION; MOLECULAR MIMICRY; RESPIRATORY CHAIN; STRUCTURE ACTIVITY RELATION; TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; ELECTRON TRANSPORT COMPLEX I; ENZYME INHIBITORS; FURANS; LACTONES; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034649561     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000911j     Document Type: Article

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