Carrier and Channel Properties of the Mitochondrial Transporters: Physiology and Pathology?

Toxicology Mechanisms and Methods

Volumn 14, Issue 1-2, 2004, Pages 41-46

  Ledesma, Amalia ^a   Rial, Eduardo ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Carrier; Channel; Fatty Acid; Mitochondria; Permeability Transition; Uncoupling

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CARRIER PROTEIN; FATTY ACID; MITOCHONDRIAL TRANSPORTER; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ANION TRANSPORT; CHANNEL GATING; CONFERENCE PAPER; FATTY ACID TRANSPORT; MITOCHONDRIAL RESPIRATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROBABILITY; PROTEIN DOMAIN; PROTEIN FAMILY; SACCHAROMYCES CEREVISIAE; TRANSPORT KINETICS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0842284225     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376520490257437     Document Type: Conference Paper

References (53)

1. Andreyev, A. Y., Bondareva, T. O., Dedukhova, V. I., Mokhova, E. N., Skulachev, V. P., and Volkov, N. I. 1988. Carboxyatractylate inhibits the uncoupling effect of free fatty acids. FEBS Lett. 226:265-269.
2. Aquila, H., Link T. A., and Klingenberg, M. 1987. Solute carriers involved in energy transfer of mitochondria form a homologous protein family. FEBS Lett. 212:1-9.
3. Arechaga, I., Ledesma, A., and Rial, E. 2001. The mitochondrial uncoupling protein UCP1: a gated pore. IUBMB Life 52:165-173.
4. Belzacq, A. S., Vieira, H. L. A., Kroemer, G., and Brenner, C. 2002. The adenine nucleotide in apoptosis. Biochemie 84:167-176.
5. Bemardi, P., Penzo, D., and Wojtczak, L. 2002. Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death. Vitam. Horm. 65:97-126.
6. Bouillaud, F., Arechaga, I., Petit, P. X., Raimbault, S., Levi-Meyrueis, C., Casteilla, L., Laurent, M., Rial, E., and Ricquier, D. 1994. A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein. EMBO J. 13:1990-1997.
7. Bouillaud, F., Casteilla, L., and Ricquier, D. 1992. A conserved domain in mitochondrial transporters is homologous to a zinc-finger knuckle of nuclear hormone receptors. Mol. Biol. Evolut. 9:970-975.
8. + exchange and a substrate-gated anion conductance. Biochem. J. 346:705-710.
9. Brown, G. C., Nicholls, D. G., and Cooper, C. E. Eds. 1999. Mitochondria and cell death. Biochem. Soc. Symp. 66.
10. 2+. Biochemistry 35:8483-8488.
11. 2+-dependent channel formed by recombinant ADP/ATP carrier from Neurospora crassa resembles the mitochondrial permeability transition pore. Biochemistry 41:11804-11811.
12. Cammack, J. N., and Schwartz, E. A. 1996. Channel behavior in a γ-aminobutyrate transporter. Proc. Natl. Acad. Sci. USA 93:723-727.
13. Costantini, P., Belzacq, A. S., Vieira, H. L. A., Larochette, N., de Pablo, M. A., Zamzami, N., Susin, S. A., Brenner, C., and Kroemer, G. 2000. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 19:307-314.
14. 2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J. 255:357-360.
15. de Pablo, M. A., Susin, S. A., Jacotot, E., Larochette, N., Costantini, P., Ravagnan, L., Zamzami, N., and Kroemer, G. 1999. Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis 4:81-87.
16. Dierks, T., Stappen, R., and Krämer, R. 1994. Channel properties of mitochondrial carriers. In Molecular Biology of Mitochondrial Transport Systems, ed. M. Forte and M. Colombini, 117-129. Berlin: Springer-Verlag.
17. Dierks, T., Salentin, A., Heberger, C., and Krämer, R. 1990. The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents. Biochim. Biophys. Acta 1028:268-280.
18. González-Barroso, M. M., Fleury, C., Jiménez, M. A., Sanz, J. M., Romero, A., Bouillaud, F., and Rial, E. 1999. Structural and functional study of a conserved region in the uncoupling protein UCPI: the three matrix loops are involved in the control of transport. J. Mol. Biol. 292:137-149.
19. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem. J. 268:153-160.
20. Halestrap, A. P., McStay, G. P., and Clarke, S. J. 2002. The permeability transition pore complex: another view. Biochimie 84:153-166.
21. Halestrap, A. P., Woodfield, K. Y., and Connern, C. P. 1997. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272:3346-3354.
22. Herick, K., Krämer, R., and Lühring, H. 1997. Patch clamp investigation into the phosphate carrier from Saccharomyces cerevisiae mitochondria. Biochim. Biophys. Acta 1321:207-220.
23. Herick, K., and Krämer, R. 1995. Kinetic and energetic characterization of solute flux through the reconstituted aspartate/glutamate carrier from beef heart mitochondria after modification with mercurials. Biochim. Biophys. Acta 1238:63-71.
24. Huang, S. G., and Klingenberg, M. 1996. Chloride channel properties of the uncoupling protein from brown adipose tissue mitochondria: a patch-clamp study. Biochemistry 35:16806-16814.
25. Indiveri, C., Tonazzi, A., Dierks, T., Krämer, R., and Palmieri, F. 1992. The mitochondrial carnitine carrier: characterization of SH-groups relevant for its transport function. Biochim. Biophys. Acta 1140:53-58.
26. Klingenberg, M. 1991. Mechanistic and energetic aspects of carrier catalysis exemplified with mitochondrial translocators. In A Study of Enzymes: Mechanism of Enzyme Ation, ed. S. A. Kuby, 367-390. Boca Raton, FL: CRC Press.
27. Krämer, R. 1994. Functional principles of solute transport systems: concepts and perspectives. Biochim. Biophys. Acta 1185:1-34.
28. Krämer, R. 1998. Mitochondrial carrier proteins can reversible change their transport mode: the cases of the aspartate/glutamate carrier and the phosphate carrier. Exp. Physiol. 83:259-265.
29. Krupka, R. M. 1995. Interpreting the effects of specific protein modification on antiport coupling mechanisms: the case of the aspartate/glutamate exchange. Biochim. Biophys. Acta 1236:1-9.
30. Kuan, J., and Saier, M. H. 1993. The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. Crit. Rev. Biochem. Mol. Biol. 28:209-223.
31. Ledesma, A., García de Lacoba, M., Arechaga, I., and Rial, E. 2002a. Modeling the transmembrane arrangement of the uncoupling protein UCPI and topological considerations of the nucleotide-binding site. J. Bioenerg. Biomembr. 34:473-486.
32. Ledesma, A., García de Lacoba, M., and Rial, E. 2002b. The mitochondrial uncoupling proteins. Genome Biol. 3:3015.1-3015.9.
33. Listenberger, L. L., and Schaffer, J. E. 2002. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc. Med. 12:134-138.
34. Majima, E., Ikawa, K., Takeda, M., Hashimoto, M., Shinohara, Y., and Terada, H. 1995. Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline. J. Biol. Chem. 270:29548-29554.
35. Mayinger, P., and Klingenberg, M. 1992. Labeling of two different regions of the nucleotide binding site of the uncoupling protein from brown adipose tissue mitochondria with two ATP analogs. Biochemistry 31:10536-10543.
36. Modriansky, M., Murdza-Inglis, D., Patel, H. V., Freeman, K. B., and Garlid, K. D. 1997. Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition. J. Biol. Chem. 272:24759-24762.
37. Palmieri, F., Indiveri, C., Bisaccia, F., and Krämer, R. 1993. Functional properties of purified and reconstituted mitochondrial metabolite carriers. J. Bioenerg. Biomembr. 25:525-535.
38. + channel. J. Biol. Chem. 276:1728-1734.
39. Rial, E., and González-Barroso, M. M. 2001. Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2. Biochim. Biophys. Acta 1504:70-81.
40. Ricquier, D., and Bouillaud, F. 2000. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345:161-179.
41. Samartsev, V. N., Smirnov, A. V., Zeldi, I. P., Markova, O. V., Mokhova, E. N., and Skulachev, V. P. 1997. Involvement of aspartate/glutamate antiporter in fatty-acid-induced uncoupling of liver mitochondria. Biochim. Biophys. Acta 1319:251-257.
42. Schönfeld, P., and Bohenensack, R. 1997. Fatty-acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier. FEBS Lett. 420:167-170.
43. Schönfeld, P., Wieckowski, M. R., and Wojtczak, L. 2000. Long-chain fatty-acid-promoted swelling of mitochondria: further evidence for the protonophoric effect of fatty acids in the inner mitochondrial membrane. FEBS Lett. 471:108-112.
44. Schwarz, M., Gross, A., Steinkamp, T., Flügge, U. I., and Wagner, R. 1994. Ion channel properties of the reconstituted chloroplast triose phosphate/phosphate translocator. J. Biol. Chem. 269:29481-29489.
45. Skulachev, V. P. 1991. Fatty acid circuit as a physiological of uncoupling of oxidative phosphorylation. FEBS Lett. 294:158-162.
46. Stappen, R., and Krämer, R. 1993. Functional properties of the reconstituted phosphate carrier from bovine heart mitochondria: evidence for asymmetric orientation and characterization of three different transport modes. Biochim. Biophys. Acta 1149:40-48.
47. Unger, R. H., and Orci, L. 2001. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J. 15:312-321.
48. Walker, J. E., and Runswick M. J. 1993. The mitochondrial transport protein superfamily. J. Bioenerg. Biomembr. 25:435-446.
49. Wieckowski, M. R., and Wojtczak, L. 1997. Involvement of the dicarboxylate carrier in the protonophoric action of long-chain fatty acids in mitochondria. Biochem. Biophys. Res. Commun. 232:414-417.
50. Winkler, E., and Klingenberg, M. 1992. Photoaffinity labeling of the nucleotide-binding site of the uncoupling protein from hamster brown adipose tissue. Eur. J. Biochem. 203:295-304.
51. Wojtczak, L., and Schönfeld, P. 1993. Effect of fatty acids on energy coupling processes in mitochondria. Biochim. Biophys. Acta 1183:41-57.
52. Zackova, M., Krämer, R., and Jezek, P. 2000. Interaction of mitochondrial phosphate carrier with fatty acids and hydrophobic phosphate analogs. Int. J. Biochem. Cell Biol. 32:499-508.
53. Zoratti, M., and Szabò, I. 1995. The mitochondrial permeability transition. Biochim. Biophys. Acta 1241:139-176.