Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

Infection and Immunity

Volumn 72, Issue 2, 2004, Pages 1184-1187

  Larsson, Charlotte ^a   Holmgren, Jan ^b   Lindahl, Gunnar ^a   Bergquist, Charlotta ^b  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CELL SURFACE PROTEIN; CHOLERA TOXIN B SUBUNIT; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; RIB PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS INFECTION; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; CHOLERA TOXIN; FEMALE; IMMUNIZATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE; VACCINES, CONJUGATE;

EID: 0842282992     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.2.1184-1187.2004     Document Type: Article

References (27)

1. Areschoug, T., M. Stålhammar-Carlemalm, C. Larsson, and G. Lindahl. 1999. Group B streptococcal surface proteins as targets for protective antibodies: identification of two novel proteins in strains of serotype V. Infect. Immun. 67:6350-6357.
2. Baker, C. J., M. A. Rench, M. S. Edwards, R. J. Carpenter, B. M. Hays, and D. L. Kasper. 1988. Immunization of pregnant women with a polysaccharide vaccine of group B streptococcus. N. Engl. J. Med. 319:1180-1185.
3. Bergquist, C., E. L. Johansson, T. Lagergård, J. Holmgren, and A. Rudin. 1997. Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. 65:2676-2684.
4. Bergquist, C., T. Lagergård, and J. Holmgren. 1997. Anticarrier immunity suppresses the antibody response to polysaccharide antigens after intranasal immunization with the polysaccharide-protein conjugate. Infect Immun. 65:1579-1583.
5. Bergquist, C., T. Lagergård, M. Lindblad, and J. Holmgren. 1995. Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates. Infect. Immun. 63:2021-2025.
6. Brodeur, B. R., M. Boyer, I. Charlebois, J. Hamel, F. Couture, C. R. Rioux, and D. Martin. 2000. Identification of group B streptococcal Sip protein, which elicits cross-protective immunity. Infect. Immun. 68:5610-5618.
7. Edwards, M. S., and C. J. Baker. 2001. Group B streptococcal infections, p. 1091-1156. In J. S. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant. W. B. Saunders Company, Philadelphia, Pa.
8. Hordnes, K., A. Digranes, I. L. Haugen, D. E. Helland, M. Ulstein, R. Jonsson, and B. Haneberg. 1995. Systemic and mucosal antibody responses to group B streptococci following immunization of the colonic-rectal mucosa. J. Reprod. Immunol. 28:247-262.
9. Hordnes, K., T. Tynning, T. A. Brown, B. Haneberg, and R. Jonsson. 1997. Nasal immunization with group B streptococci can induce high levels of specific IgA antibodies in cervicovaginal secretions of mice. Vaccine 15:1244-1251.
10. Hordnes, K., T. Tynning, A. I. Kvam, L. Bevanger, T. A. Brown, R. Jonsson, and B. Haneberg. 1998. Cervical secretions in pregnant women colonized rectally with group B streptococci have high levels of antibodies to serotype III polysaccharide capsular antigen and protein R. Scand. J. Immunol. 47:179-188.
11. Hordnes, K., T. Tynning, A. I. Kvam, R. Jonsson, and B. Haneberg. 1996. Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women. Infect. Immun. 64:1643-1652.
12. Hunter, S. K., M. E. Andracki, and A. M. Krieg. 2001. Biodegradable microspheres containing group B streptococcus vaccine: immune response in mice. Am. J. Obstet. Gynecol. 185:1174-1179.
13. Johansson, E. L., C. Rask, M. Fredriksson, K. Eriksson, C. Czerkinsky, and J. Holmgren. 1998. Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates. Infect. Immun. 66:514-520.
14. Johansson, E. L., L. Wassen, J. Holmgren, M. Jertborn, and A. Rudin. 2001. Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans. Infect. Immun. 69:7481-7486.
15. Lachenauer, C. S., C. J. Baker, M. J. Baron, D. L. Kasper, C. Gravekamp, and L. C. Madoff. 2002. Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum. J. Infect. Dis. 185:368-374.
16. Lagergård, T., J. Shiloach, J. B. Robbins, and R. Schneerson. 1990. Synthesis and immunological properties of conjugates composed of group B streptococcus type III capsular polysaccharide covalently bound to tetanus toxoid. Infect. Immun. 58:687-694.
17. Larsson, C., M. Stålhammar-Carlemalm, and G. Lindahl. 1996. Experimental vaccination against group B streptococcus, an encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and α. Infect. Immun. 64:3518-3523.
18. Larsson, C., M. Stålhammar-Carlemalm, and G. Lindahl. 1999. Protection against experimental infection with group B streptococcus by immunization with a bivalent protein vaccine. Vaccine 17:454-458.
19. Lebens, M., S. Johansson, J. Osek, M. Lindblad, and J. Holmgren. 1993. Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines. Bio/Technology (New York) 11:1574-1578.
20. Madoff, L. C., J. L. Michel, E. W. Gong, A. K. Rodewald, and D. L. Kasper. 1992. Protection of neonatal mice from group B streptococcal infection by maternal immunization with beta C protein. Infect. Immun. 60:4989-4994.
21. Musser, J. M., S. J. Mattingly, R. Quentin, A. Goudeau, and R. K. Selander. 1989. Identification of a high-virulence clone of type III Streptococcus agalactiae (group B streptococcus) causing invasive neonatal disease. Proc. Natl. Acad. Sci. USA 86:4731-4735.
22. Rudin, A., E. L. Johansson, C. Bergquist, and J. Holmgren. 1998. Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66:3390-3396.
23. Russell, M. W., Z. Moldoveanu, P. L. White, G. J. Sibert, J. Mestecky, and S. M. Michalek. 1996. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
24. Shen, X., T. Lagergård, Y. Yang, M. Lindblad, M. Fredriksson, and J. Holmgren. 2000. Systemic and mucosal immune responses in mice after mucosal immunization with group B streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate vaccine. Infect. Immun. 68:5749-5755.
25. Stålhammar-Carlemalm, M., L. Stenberg, and G. Lindahl. 1993. Protein Rib: a novel group B streptococcal cell surface protein that confers protective immunity and is expressed by most strains causing invasive infections. J. Exp. Med. 177:1593-1603.
26. Wåstfelt, M., M. Stålhammar-Carlemalm, A. M. Delisse, T. Cabezon, and G. Lindahl. 1996. Identification of a family of streptococcal surface proteins with extremely repetitive structure. J. Biol. Chem. 271:18892-18897.
27. Wessels, M. R., L. C. Paoletti, D. L. Kasper, J. L. DiFabio, F. Michon, K. Holme, and H. J. Jennings. 1990. Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B streptococcus. J. Clin. Investig. 86:1428-1433.