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Volumn 102, Issue 8, 1998, Pages 1599-1608

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

Author keywords

FGF 2; FGF 7; Fibroblast growth factor; Heparan sulfate; Proteoglycans

Indexed keywords

KERATINOCYTE GROWTH FACTOR; PERLECAN;

EID: 3643129096     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3793     Document Type: Article
Times cited : (175)

References (41)
  • 1
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D., and J. Folkman. 1996. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 2
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren, L., M. O'Reilly, and J. Folkman. 1995. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1:149-153.
    • (1995) Nat. Med. , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.2    Folkman, J.3
  • 3
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly, M.S., L. Holmgren, C. Chen, and J. Folkman. 1996. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2: 689-692.
    • (1996) Nat. Med. , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 4
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: What is its molecular basis?
    • Folkman, J., and P.A. D'Amore. 1996. Blood vessel formation: what is its molecular basis? Cell. 87:1153-1155.
    • (1996) Cell , vol.87 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 5
    • 0031657808 scopus 로고    scopus 로고
    • Matrix proteoglycans: From molecular design to cellular function
    • Iozzo, R.V. 1998. Matrix proteoglycans: from molecular design to cellular function. Annu. Rev. Biochem. 67:609-652.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 609-652
    • Iozzo, R.V.1
  • 6
    • 0026317977 scopus 로고
    • The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule
    • Noonan, D.M., A. Fulle, P. Valente, S. Cai, E. Horigan, M. Sasaki, Y. Yamada, and J.R. Hassell. 1991. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J. Biol. Chem. 266:22939-22947.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22939-22947
    • Noonan, D.M.1    Fulle, A.2    Valente, P.3    Cai, S.4    Horigan, E.5    Sasaki, M.6    Yamada, Y.7    Hassell, J.R.8
  • 7
    • 0028102255 scopus 로고
    • The biology of perlecan: The multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices
    • Iozzo, R.V., I.R. Cohen, S. Grässel, and A.D. Murdoch. 1994. The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochem. J. 302:625-639.
    • (1994) Biochem. J. , vol.302 , pp. 625-639
    • Iozzo, R.V.1    Cohen, I.R.2    Grässel, S.3    Murdoch, A.D.4
  • 8
    • 0030806072 scopus 로고    scopus 로고
    • Developmental expression of perlecan during murine embryogenesis
    • Handler, M., P.D. Yurchenco, and R.V. lozzo. 1997. Developmental expression of perlecan during murine embryogenesis. Dev. Dyn. 210:130-145.
    • (1997) Dev. Dyn. , vol.210 , pp. 130-145
    • Handler, M.1    Yurchenco, P.D.2    Lozzo, R.V.3
  • 10
    • 0026738891 scopus 로고
    • Differential expression of proteoglycans on the surface of human melanoma cells characterized by altered experimental metastatic potential
    • Timar, J., A. Ladanyi, K. Lapis, and M. Moczar. 1992. Differential expression of proteoglycans on the surface of human melanoma cells characterized by altered experimental metastatic potential. Am. J. Pathol 141:467-474.
    • (1992) Am. J. Pathol , vol.141 , pp. 467-474
    • Timar, J.1    Ladanyi, A.2    Lapis, K.3    Moczar, M.4
  • 11
    • 0024215608 scopus 로고
    • Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor
    • Vigny, M., M.P. Ollier-Hartmann, M. Lavigne, N. Fayein, J.C. Jeanny, M. Laurent, and Y. Courtois. 1988. Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor. J. Cell. Physiol. 137:321-328.
    • (1988) J. Cell. Physiol. , vol.137 , pp. 321-328
    • Vigny, M.1    Ollier-Hartmann, M.P.2    Lavigne, M.3    Fayein, N.4    Jeanny, J.C.5    Laurent, M.6    Courtois, Y.7
  • 12
    • 0028579734 scopus 로고
    • Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
    • Aviezer, D., D. Hecht, M. Safran, M. Eisinger, G. David, and A. Yayon. 1994. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell. 79:1005-1013.
    • (1994) Cell , vol.79 , pp. 1005-1013
    • Aviezer, D.1    Hecht, D.2    Safran, M.3    Eisinger, M.4    David, G.5    Yayon, A.6
  • 13
    • 0025976838 scopus 로고
    • Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
    • Yayon, A., M. Klagsbrun, J.D. Esko, P. Leder, and D.M. Ornitz. 1991. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 64:841-848.
    • (1991) Cell , vol.64 , pp. 841-848
    • Yayon, A.1    Klagsbrun, M.2    Esko, J.D.3    Leder, P.4    Ornitz, D.M.5
  • 14
    • 0026502460 scopus 로고
    • Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
    • Ornitz, D.M., A. Yayon, J.G. Flanagan, C.M. Svahn, E. Levi, and P. Leder. 1992. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 12:240-247.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 240-247
    • Ornitz, D.M.1    Yayon, A.2    Flanagan, J.G.3    Svahn, C.M.4    Levi, E.5    Leder, P.6
  • 15
    • 0029876376 scopus 로고    scopus 로고
    • The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin and heparanases
    • Whitelock, J.M., A.D. Murdoch, R.V. Iozzo, and P.A. Underwood. 1996. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin and heparanases. J. Biol. Chem. 271:10079-10086.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10079-10086
    • Whitelock, J.M.1    Murdoch, A.D.2    Iozzo, R.V.3    Underwood, P.A.4
  • 16
    • 0030945178 scopus 로고    scopus 로고
    • Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA
    • Aviezer, D., R.V. Iozzo, D.M. Noonan, and A. Yayon. 1997. Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA. Mol. Cell. Biol. 17:1938-1946.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1938-1946
    • Aviezer, D.1    Iozzo, R.V.2    Noonan, D.M.3    Yayon, A.4
  • 17
    • 0031462263 scopus 로고    scopus 로고
    • Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA
    • Adatia, R., A. Albini, S. Carlone, D. Giunciuglio, R. Benelli, L. Santi, and D.M. Noonan. 1998. Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA. Ann. Oncol. 8:1257-1261.
    • (1998) Ann. Oncol. , vol.8 , pp. 1257-1261
    • Adatia, R.1    Albini, A.2    Carlone, S.3    Giunciuglio, D.4    Benelli, R.5    Santi, L.6    Noonan, D.M.7
  • 18
    • 0030958891 scopus 로고    scopus 로고
    • A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells
    • Mathiak, M., C. Yenisey, D.S. Grant, B. Sharma, and R.V. Iozzo. 1997. A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells. Cancer Res. 57:2130-2136.
    • (1997) Cancer Res. , vol.57 , pp. 2130-2136
    • Mathiak, M.1    Yenisey, C.2    Grant, D.S.3    Sharma, B.4    Iozzo, R.V.5
  • 19
    • 0026758187 scopus 로고
    • Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor
    • Murdoch, A.D., G.R. Dodge, I. Cohen, R.S. Tuan, and R.V. Iozzo. 1992. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J. Biol. Chem. 267:8544-8557.
    • (1992) J. Biol. Chem. , vol.267 , pp. 8544-8557
    • Murdoch, A.D.1    Dodge, G.R.2    Cohen, I.3    Tuan, R.S.4    Iozzo, R.V.5
  • 20
    • 0029088680 scopus 로고
    • De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells
    • Santra, M., T. Skorski, B. Calabretta, E.C. Lattime, and R.V. Iozzo. 1995. De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc. Natl. Acad. Sci. USA. 92:7016-7020.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7016-7020
    • Santra, M.1    Skorski, T.2    Calabretta, B.3    Lattime, E.C.4    Iozzo, R.V.5
  • 21
    • 0032549020 scopus 로고    scopus 로고
    • Transcriptional silencing of perlecan gene expression by interferon-γ
    • Sharma, B., and R.V. lozzo. 1998. Transcriptional silencing of perlecan gene expression by interferon-γ. J. Biol. Chem. 273:4642-4646.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4642-4646
    • Sharma, B.1    Lozzo, R.V.2
  • 22
    • 0028158005 scopus 로고
    • Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization
    • Murdoch, A.D., B. Liu, R. Schwarting, R.S. Tuan, and R.V. Iozzo. 1994. Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. J. Histochem. Cytochem. 42:239-249.
    • (1994) J. Histochem. Cytochem. , vol.42 , pp. 239-249
    • Murdoch, A.D.1    Liu, B.2    Schwarting, R.3    Tuan, R.S.4    Iozzo, R.V.5
  • 23
    • 0029999241 scopus 로고    scopus 로고
    • Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate
    • Fannon, M., and M.A. Nugent. 1996. Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate. J. Biol. Chem. 271:17949-17956.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17949-17956
    • Fannon, M.1    Nugent, M.A.2
  • 24
    • 0026736833 scopus 로고
    • The FGF family of growth factors and oncogenes
    • Basilico, C., and D. Moscatello. 1992. The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59:115-165.
    • (1992) Adv. Cancer Res. , vol.59 , pp. 115-165
    • Basilico, C.1    Moscatello, D.2
  • 26
    • 0030855812 scopus 로고    scopus 로고
    • Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
    • Wang, Y., and D. Becker. 1997. Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Nat. Med. 3:887-893.
    • (1997) Nat. Med. , vol.3 , pp. 887-893
    • Wang, Y.1    Becker, D.2
  • 27
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis: Correlation in invasive breast carcinoma
    • Weidner, N., J.P. Semple, W.R. Welch, and J. Folkman. 1991. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N. Engl. J. Med. 324:1-8.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 28
    • 0019939323 scopus 로고
    • Enhanced metaslatic potential of tumor cells harvested from spontaneous metastases of heterogenous murine tumors
    • Talmadge, J.E., and I.J. Fidler. 1982. Enhanced metaslatic potential of tumor cells harvested from spontaneous metastases of heterogenous murine tumors. J. Natl. Cancer Inst. 69:975-980.
    • (1982) J. Natl. Cancer Inst. , vol.69 , pp. 975-980
    • Talmadge, J.E.1    Fidler, I.J.2
  • 29
    • 0024817936 scopus 로고
    • Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor
    • Becker, D., C.B. Meier, and M. Herlyn. 1989. Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor. EMBO (Eur. Mol. Biol. Organ.) J. 8: 3685-3691.
    • (1989) EMBO (Eur. Mol. Biol. Organ.) J. , vol.8 , pp. 3685-3691
    • Becker, D.1    Meier, C.B.2    Herlyn, M.3
  • 33
    • 0030010512 scopus 로고    scopus 로고
    • Proteoglycans of the extracellular environment: Clues from the gene and protein side offer novel perspectives in molecular diversity and function
    • Iozzo, R.V., and A.D. Murdoch. 1996. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB (Fed. Am. Soc. Exp. Biol.) J. 10:598-614.
    • (1996) FASEB (Fed. Am. Soc. Exp. Biol.) J. , vol.10 , pp. 598-614
    • Iozzo, R.V.1    Murdoch, A.D.2
  • 35
    • 0030752271 scopus 로고    scopus 로고
    • Endothelial proteoglycans inhibit bFGF binding and mitogenesis
    • Forsten, K.E., N.A. Courant, and M.A. Nugent. 1997. Endothelial proteoglycans inhibit bFGF binding and mitogenesis. J. Cell. Physiol 172:209-220.
    • (1997) J. Cell. Physiol , vol.172 , pp. 209-220
    • Forsten, K.E.1    Courant, N.A.2    Nugent, M.A.3
  • 38
    • 0030873165 scopus 로고    scopus 로고
    • Pieces of eight-bioactive fragments of extracellular proteins as regulators of angiogenesis
    • Sage, E.H. 1997. Pieces of eight-bioactive fragments of extracellular proteins as regulators of angiogenesis. Trends Cell Biol. 7:182-186.
    • (1997) Trends Cell Biol. , vol.7 , pp. 182-186
    • Sage, E.H.1
  • 39
    • 0032536859 scopus 로고    scopus 로고
    • Crystal structure of the angiogenesis inhibitor endostatin in 1.5Å resolution
    • Hohenester, E., T. Sasaki, B.R. Olsen, and R. Timpl. 1998. Crystal structure of the angiogenesis inhibitor endostatin in 1.5Å resolution. EMBO (Eur. Mol. Biol. Organ.) J. 17:1656-1664.
    • (1998) EMBO (Eur. Mol. Biol. Organ.) J. , vol.17 , pp. 1656-1664
    • Hohenester, E.1    Sasaki, T.2    Olsen, B.R.3    Timpl, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.