Common pathogenic mechanisms in ASH and NASH

Hepatology Research

Volumn 28, Issue 1, 2004, Pages 18-20

  Ishii, Hiromasa ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; CYTOCHROME P450 2E1; ENDOTOXIN; ISONIAZID; OXYGEN RADICAL; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ALCOHOLIC FATTY LIVER; DRUG EFFICACY; EDITORIAL; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROGENESIS; HUMAN; INSULIN RESISTANCE; LIPID PEROXIDATION; LIPOLYSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0742271378     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2003.11.001     Document Type: Editorial

References (36)

1. Ludwig J. Viggiano T.R. McGill D.B. Oh B.J. Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease Mayo Clin Proc 55 1980 434-438
2. Falck-Ytter Y. Younossi Z.M. Marchisini G. McCullough A.J. Clinical features and natural history of nonalcoholic steatosis syndromes Semin Liver Dis 21 2001 17-26
3. Lieber C.S. Cytochrome P4502E1: its physiological and pathological role Physiol Rev 77 1997 517-544
4. Lieber C.S. DeCarli L.M. Hepatic microsomal ethanol oxidizing system. In vitro characteristics and adaptive properties in vivo J Biol Chem 245 1970 2505-2512
5. Lieber C.S. Garro A. Leo M.A. Mak K.M. Worner T. Alcohol and cancer Hepatology 6 1986 1005-1019
6. Weltman M.D. Farrell G.C. Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation Gastroenterology 111 1996 1645-1653
7. Weltman M.D. Farrell G.C. Hall P. Ingelman-Sundberg M. Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis Hepatology 27 1998 113-128
8. Chalasani N. Gorski J.C. Asghar M.S. Asghar A. Foresman B. Hall S.D. et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis Hepatology 37 2003 544-550
9. Emery M.G. Fisher J.M. Chien J.Y. Kharasch E.D. Dellinger E.P. Kowdley K.V. et al. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease Hepatology 38 2003 428-435
10. Robertson G. Leclercq I. Farrell G.C. Nonalcoholic steatosis and steatohepatitis. Part II. Cytochrome P-450 enzymes and oxidative stress Am J Physiol Gastrointest Liver Physiol 281 2001 G1135-G1139
11. Neuschwander-Tetri B.A. Caldwell S.H. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference Hepatology 37 2003 1202-1219
12. Leclercq I. Farrell G. Field J. Bell D.R. Gonzalez F.J. Robertson G.R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis J Clin Invest 105 2000 1067-1075
13. Seki S. Kitada T. Yamada T. Sakaguchi H. Nakatani K. Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in nonalcoholic fatty liver disease J Hepatol 37 2002 56-62
14. Chitturi S. Farrell G.C. Etiopathogenesis of nonalcoholic steatohepatitis Semin Liver Dis 21 2001 27-41
15. Tamai H. Horie Y. Kato S. Yokoyama H. Ishii H. Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats Alcohol Clin Exp Res 26 2002 75S-80S
16. Su G.L. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation Am J Physiol Gastrointest Liver Physiol 283 2002 G256-G265
17. Adachi Y. Moore L.E. Bradford B.U. Gao W. Thurman R.G. Antibiotics prevent liver injury in rats following long-term exposure to ethanol Gastroenterology 108 1995 218-224
18. Cope K. Risby T. Diehl A.M. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis Gastroenterology 119 2000 1340-1347
19. Li Z. Yang S. Lin H. Huang J. Watkins P.A. Moser A.B. et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2003 343-350
20. Nair S. Cope K. Risby T.H. Diehl A.M. Terence R.H. Obesity and female gender increases breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis Am J Gastroenterol 96 2001 1200-1204
21. Allard J.P. Other disease associations with non-alcoholic fatty liver disease (NAFLD) Best Pract Res Clin Gastroenterol 16 2002 783-795
22. Jarvelainen H.A. Orpana A. Perola M. Savolainen V.T. Karhumen P.J. Lindros K.O. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease Hepatology 33 2001 1148-1153
23. Day C. CD14 promoter polymorphism associated with risk of NASH J Hepatol 36 2002 21
24. Solga S.F. Diehl A.M. Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics J Hepatol 38 2003 681-687
25. Yin M. Wheeler M.D. Kono H. Bradford B.U. Gallucci R.M. Luster M.I. et al. Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice Gastroenterology 117 1999 942-952
26. Tilg H. Diehl A.M. Cytokines in alcoholic and nonalcoholic steatohepatitis N Engl J Med 343 2003 1467-1476
27. Tilg H. Jalan R. Kaser A. Davies N.A. Offner F.A. Hodges S.J. et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis J Hepatol 38 2003 419-425
28. Hotamisligil G.S. Shargill N.S. Spiegelmen B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87-91
29. Uysal K.T. Wiesbrock S.M. Marino M.W. Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-α production Nature 389 1997 610-614
30. Sanyal A.J. Campbell-Sargent C. Mirshahi F. Rizzo W.B. Contos M.J. Sterling R.K. et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001-1183
31. Crespo J. Cayon A. Fernandez-Gil P. Hernandez-Guerra M. Mayorga M. Dominguez-Diez A. et al. Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis Hepatology 34 2001 1158-116
32. Valenti L. Fracanzani A.L. Dongiovannni P. Santorelli G. Branchi A. Taioli E. et al. Tumor necrosis factor α polymorphisms and insulin resistance in nonalcoholic fatty liver disease Gastroenterology 122 2002 274-280
33. Santamaria E. Avila M.A. Latasa M.U. Rubio A. Martin-Duce A. Lu S.C. et al. Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine Proc Natl Acad Sci USA 100 2003 3065-3070
34. Xu Y. Leo M.A. Lieber C.S. Lycopene attenuates arachidonic acid toxicity in HepG2 cells overexpressing CYP2E1 Biochem Biophys Res Commun 303 2003 745-750
35. Xu Y. Leo M.A. Lieber C.S. Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1 Biochem Biophys Res Commun 308 2003 614-618
36. Lieber CS, CYP2E1: from ASH to NASH, Hepatol Res, in press.